Nup62 nucleoporin 62 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nup62provided by MGI
Official Full Name: nucleoporin 62provided by MGI
Primary source: MGI:MGI:1351500
See related: Ensembl:ENSMUSG00000109511 AllianceGenome:MGI:1351500
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p62; Nupc1; D7Ertd649e
Summary: Enables Hsp70 protein binding activity; Hsp90 protein binding activity; and PTB domain binding activity. Involved in negative regulation of cell population proliferation and negative regulation of signal transduction. Acts upstream of or within cell aging. Located in nuclear membrane. Part of nuclear pore. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and integumental system. Human ortholog(s) of this gene implicated in primary biliary cholangitis and striatonigral degeneration. Orthologous to human NUP62 (nucleoporin 62). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 53.2), thymus adult (RPKM 44.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 28.93 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (44465512..44481260)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (44816088..44831836)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy.
Title: S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy.
p62 and NBR1 functions are dispensable for aggrephagy in mouse ESCs and ESC-derived neurons.
Title: p62 and NBR1 functions are dispensable for aggrephagy in mouse ESCs and ESC-derived neurons.
RNA-seq reveals Nup62 as a potential regulator for cell division after traumatic brain injury in mice hippocampus.
Title: RNA-seq reveals Nup62 as a potential regulator for cell division after traumatic brain injury in mice hippocampus.
GDF-15 Deficiency Reduces Autophagic Activity in Human Macrophages In Vitro and Decreases p62-Accumulation in Atherosclerotic Lesions in Mice.
Title: GDF-15 Deficiency Reduces Autophagic Activity in Human Macrophages In Vitro and Decreases p62-Accumulation in Atherosclerotic Lesions in Mice.
Changes in Nup62 content affect contact-induced differentiation of cultured myoblasts.
Title: Changes in Nup62 content affect contact-induced differentiation of cultured myoblasts.
Nucleoporins 107, 62 and 153 mediate Kcnq1ot1 imprinted domain regulation in extraembryonic endoderm stem cells.
Title: Nucleoporin 107, 62 and 153 mediate Kcnq1ot1 imprinted domain regulation in extraembryonic endoderm stem cells.
Role for NUP62 depletion and PYK2 redistribution in dendritic retraction resulting from chronic stress
Title: Role for NUP62 depletion and PYK2 redistribution in dendritic retraction resulting from chronic stress.
Nup62 depletion leads to the appearance of multinucleated cells and induces the formation of multipolar centrosomes, centriole synthesis defects, dramatic spindle orientation defects, and centrosome component rearrangements that impair cell bi-polarity.
Title: Nucleoporin Nup62 maintains centrosome homeostasis.
ORP8 was shown to compete with Exo70 for interaction with NUP62, and NUP62 knockdown abolished the migration enhancement of ORP8-silenced cells, suggesting that the endogenous ORP8 suppresses migration via binding to NUP62.
Title: Silencing of OSBP-related protein 8 (ORP8) modifies the macrophage transcriptome, nucleoporin p62 distribution, and migration capacity.
Dtaa show that importin beta and the integral nuclear pore glycoprotein Nup62 interact with hsp90, hsp70, p23, and the TPR domain proteins FKBP52 and PP5 during nuclear transport.
Title: Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Transgenic (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI426861 (e-PCR)
- UniSTS:179565

AU015239 (e-PCR)
- UniSTS:167534

AI790512 (e-PCR)
- UniSTS:179566

NoName (e-PCR)
- UniSTS:235658

AU045898 (e-PCR)
- UniSTS:159634

RH124961 (e-PCR)
- UniSTS:161783

Readthrough Il4i1b

Readthrough gene: Il4i1b, Included gene: Il4i1

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Hsp70 protein binding	IDA Inferred from Direct Assay more info	PubMed
enables Hsp90 protein binding	IDA Inferred from Direct Assay more info	PubMed
enables PTB domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables SH2 domain binding	ISO Inferred from Sequence Orthology more info
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor complex adaptor activity	ISO Inferred from Sequence Orthology more info
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	NAS Non-traceable Author Statement more info	PubMed
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular senescence	IDA Inferred from Direct Assay more info	PubMed
involved_in centriole assembly	ISO Inferred from Sequence Orthology more info
involved_in centrosome cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in mitotic centrosome separation	ISO Inferred from Sequence Orthology more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAP kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in nucleocytoplasmic transport	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of centriole replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cytokinetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to centrosome	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitotic spindle organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Flemming body	ISO Inferred from Sequence Orthology more info
located_in annulate lamellae	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	NAS Non-traceable Author Statement more info	PubMed
part_of nuclear pore central transport channel	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in spindle pole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear pore glycoprotein p62

Names: 62 kDa nucleoporin; nuclear pore complex 1; nucleoporin Nup62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053074.2 → NP_444304.1 nuclear pore glycoprotein p62

See identical proteins and their annotated locations for NP_444304.1

Status: VALIDATED

Source sequence(s)

AC158231, AK171611

Consensus CDS

CCDS21216.1

UniProtKB/Swiss-Prot

Q63850, Q99JN7

UniProtKB/TrEMBL

Q3THR9, Q3U2X1, Q5FWJ9

Related

ENSMUSP00000056785.10, ENSMUST00000057195.17

Conserved Domains (3) summary

COG1196
Location:367 → 521

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam05064
Location:318 → 433

Nsp1_C; Nsp1-like C-terminal region

pfam15967
Location:1 → 192

Nucleoporin_FG2; Nucleoporin FG repeated region