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dop-4 Dopamine receptor 4 [ Caenorhabditis elegans ]

Gene ID: 183715, updated on 11-Apr-2024

Summary

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Gene symbol
dop-4
Gene description
Dopamine receptor 4
Primary source
WormBase:WBGene00016872
Locus tag
CELE_C52B11.3
See related
AllianceGenome:WB:WBGene00016872
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables dopamine neurotransmitter receptor activity. Involved in adenylate cyclase-activating dopamine receptor signaling pathway. Predicted to be located in postsynaptic membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in intestine; nervous system; rectum; and vulva. Used to study alcohol use disorder. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
8
Sequence:
Chromosome: X; NC_003284.9 (1295253..1298830)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene NF-kappa-B inhibitor-interacting Ras-like protein 1 Neighboring gene pseudo Neighboring gene BTB domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dopamine receptor DOP-4 modulates habituation to repetitive photoactivation of a C. elegans polymodal nociceptor. Ardiel EL, et al. Learn Mem, 2016 Oct. PMID 27634141, Free PMC Article
  2. Neural Inhibition of Dopaminergic Signaling Enhances Immunity in a Cell-Non-autonomous Manner. Cao X, et al. Curr Biol, 2016 Sep 12. PMID 27524480, Free PMC Article
  3. Alcohol disinhibition of behaviors in C. elegans. Topper SM, et al. PLoS One, 2014. PMID 24681782, Free PMC Article
  4. Food sensitizes C. elegans avoidance behaviours through acute dopamine signalling. Ezcurra M, et al. EMBO J, 2011 Mar 16. PMID 21304491, Free PMC Article
  5. Dopamine regulates body size in Caenorhabditis elegans. Nagashima T, et al. Dev Biol, 2016 Apr 1. PMID 26921458

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study established a high-throughput learning assay that used real-time computer vision software for behavioral tracking and optogenetics for stimulation of the C. elegans polymodal nociceptor, ASH. Food and dopamine signaling slowed habituation downstream from ASH excitation via D1-like dopamine receptor, DOP-4. Assay allows for large-scale genetic and drug screens investigating mechanisms of nociception modulation.
    Title: Dopamine receptor DOP-4 modulates habituation to repetitive photoactivation of a C. elegans polymodal nociceptor.
  2. DOP-4 shows high sequence homology with D1-like dopamine receptors unique to invertebrates, distinct from mammalian D1-like dopamine receptors. Reporter gene assay showed that DOP-4 stimulates cAMP accumulation in response to dopamine stimulation.
    Title: Characterization of a novel D2-like dopamine receptor with a truncated splice variant and a D1-like dopamine receptor unique to invertebrates from Caenorhabditis elegans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dopamine neurotransmitter receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled serotonin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating dopamine receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic transmission, dopaminergic IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic membrane IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
Dopamine receptor 4
NP_508238.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    1295253..1298830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_075837.5 → NP_508238.2  Dopamine receptor 4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508238.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18775
    Conserved Domains (2) summary
    pfam00001
    Location:59 → 463
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:53 → 245
    7tm_4; Olfactory receptor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q18775.2

Gene LinkOut

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