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DTNB dystrobrevin beta [ Homo sapiens (human) ]

Gene ID: 1838, updated on 5-Mar-2024

Summary

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Official Symbol
DTNBprovided by HGNC
Official Full Name
dystrobrevin betaprovided by HGNC
Primary source
HGNC:HGNC:3058
See related
Ensembl:ENSG00000138101 MIM:602415; AllianceGenome:HGNC:3058
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in salivary gland (RPKM 3.0), brain (RPKM 2.3) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
2p23.3
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (25377243..25673577, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (25412572..25708881, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (25600112..25896446, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11246 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11247 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25439263-25439780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15444 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25452372-25453102 Neighboring gene long intergenic non-protein coding RNA 1381 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25469436-25469945 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25470965-25471472 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11248 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11249 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25476274-25476808 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25482555-25483258 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25486869-25487452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25487453-25488037 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25492834-25493424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25495919-25496419 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15445 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25499151-25499742 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25500333-25500922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25500923-25501512 Neighboring gene DNA methyltransferase 3 alpha Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11252 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15446 Neighboring gene Sharpr-MPRA regulatory region 14395 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25519631-25520132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25528967-25529467 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25528466-25528966 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25531317-25531818 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25531819-25532318 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25535893-25536656 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25536657-25537420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25544961-25545788 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25553395-25553895 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25552894-25553394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25557143-25557814 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11253 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11254 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11255 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11256 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15447 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25578935-25579435 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25581309-25581844 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15448 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15449 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15450 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 2:25596509 Neighboring gene microRNA 1301 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15453 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15454 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15455 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15456 Neighboring gene uncharacterized LOC124900608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15457 Neighboring gene DTNB antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15458 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15459 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 2:25722050 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:25724405-25724507 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 2:25741070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15461 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 2:25749376 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:25757983-25758812 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 2:25761103 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:25781041-25781736 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 2:25786543 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 2:25787416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15462 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11262 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:25827447-25827680 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 2:25873082 Neighboring gene Sharpr-MPRA regulatory region 7937 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15463 Neighboring gene Sharpr-MPRA regulatory region 10860 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25945408-25946199 Neighboring gene uncharacterized LOC105374332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25966542-25967042 Neighboring gene uncharacterized LOC124906191 Neighboring gene ASXL transcriptional regulator 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer's disease-associated genes: DTNB and DLG2. Prokopenko D, et al. Mol Psychiatry, 2022 Apr. PMID 35246634, Free PMC Article
  2. Identification of β-Dystrobrevin as a Direct Target of miR-143: Involvement in Early Stages of Neural Differentiation. Quaranta MT, et al. PLoS One, 2016. PMID 27223470, Free PMC Article
  3. beta-dystrobrevin, a new member of the dystrophin family. Identification, cloning, and protein associations. Peters MF, et al. J Biol Chem, 1997 Dec 12. PMID 9395493
  4. Muscular dystrophies and the dystrophin-glycoprotein complex. Straub V, et al. Curr Opin Neurol, 1997 Apr. PMID 9146999
  5. Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk. Broderick P, et al. Nat Genet, 2011 Nov 27. PMID 22120009, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer's disease-associated genes: DTNB and DLG2.
    Title: Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer's disease-associated genes: DTNB and DLG2.
  2. Data provide new insights into the role of beta-dystrobrevin in the molecular mechanisms underlying neuronal differentiation that could be relevant in the establishment of the cognitive impairment in Duchene muscular dystrophy.
    Title: Identification of β-Dystrobrevin as a Direct Target of miR-143: Involvement in Early Stages of Neural Differentiation.
  3. beta-dystrobrevin interacts with the HMG20 proteins iBRAF and BRAF35
    Title: The interaction with HMG20a/b proteins suggests a potential role for beta-dystrobrevin in neuronal differentiation.
  4. results suggest that dysbindin assembled into BLOC-1 is not a physiological binding partner of the dystrobrevins, likely due to engagement of its dystrobrevin-binding region in interactions with other subunits
    Title: Reinvestigation of the dysbindin subunit of BLOC-1 (biogenesis of lysosome-related organelles complex-1) as a dystrobrevin-binding protein.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
EBI GWAS Catalog
Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk.
EBI GWAS Catalog
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
EBI GWAS Catalog
Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations
EBI GWAS Catalog
Many sequence variants affecting diversity of adult human height.
EBI GWAS Catalog
The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC17163, MGC57126

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in basal plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in inhibitory synapse ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dystrobrevin beta
Names
DTN-B
beta-dystrobrevin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256303.2 → NP_001243232.1  dystrobrevin beta isoform 6

    Status: REVIEWED

    Source sequence(s)
    AK300019, BC016655, DB460644, Y15722
    Consensus CDS
    CCDS74496.1
    UniProtKB/TrEMBL
    B7Z6A9, E7EVB6
    Related
    ENSP00000288642.9, ENST00000288642.12
    Conserved Domains (4) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16 → 140
    EF-hand_2; EF hand
    pfam09069
    Location:144 → 232
    EF-hand_3; EF-hand
    pfam13874
    Location:434 → 519
    Nup54; Nucleoporin complex subunit 54

  2. NM_001256304.3 → NP_001243233.1  dystrobrevin beta isoform 7

    See identical proteins and their annotated locations for NP_001243233.1

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    UniProtKB/TrEMBL
    B7Z6A9, Q1I0L3
    Conserved Domains (4) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16 → 140
    EF-hand_2; EF hand
    pfam09069
    Location:144 → 232
    EF-hand_3; EF-hand
    pfam13874
    Location:434 → 519
    Nup54; Nucleoporin complex subunit 54

  3. NM_001256308.2 → NP_001243237.1  dystrobrevin beta isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC019144, AK301386, BC016655
    UniProtKB/TrEMBL
    B7Z6A9
    Related
    ENST00000496972.6
    Conserved Domains (4) summary
    cd02334
    Location:184 → 232
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:1 → 83
    EF-hand_2; EF hand
    pfam09069
    Location:87 → 175
    EF-hand_3; EF-hand
    pfam13874
    Location:377 → 462
    Nup54; Nucleoporin complex subunit 54

  4. NM_001320932.2 → NP_001307861.1  dystrobrevin beta isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC012074, AC104699, AK225724, BC016655, DB460644
    UniProtKB/Swiss-Prot
    O60941
    Conserved Domains (3) summary
    cd02334
    Location:37 → 85
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:1 → 28
    EF-hand_3; EF-hand
    pfam13874
    Location:230 → 315
    Nup54; Nucleoporin complex subunit 54

  5. NM_001320933.2 → NP_001307862.1  dystrobrevin beta isoform 10

    Status: REVIEWED

    Source sequence(s)
    BC016655, BU846095, BX389926, DB460644, HY302507
    Consensus CDS
    CCDS82428.1
    UniProtKB/TrEMBL
    B7Z6A9, E9PEY4
    Related
    ENSP00000385784.1, ENST00000407186.5
    Conserved Domains (4) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16 → 140
    EF-hand_2; EF hand
    pfam09069
    Location:144 → 232
    EF-hand_3; EF-hand
    pfam13874
    Location:404 → 489
    Nup54; Nucleoporin complex subunit 54

  6. NM_001320934.2 → NP_001307863.1  dystrobrevin beta isoform 11

    Status: REVIEWED

    Source sequence(s)
    AF022728, BC016655, BU846095, BX389926, DB460644, HY302507
    UniProtKB/TrEMBL
    B7Z6A9
    Conserved Domains (4) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16 → 140
    EF-hand_2; EF hand
    pfam09069
    Location:144 → 232
    EF-hand_3; EF-hand
    pfam13874
    Location:404 → 487
    Nup54; Nucleoporin complex subunit 54

  7. NM_001320935.2 → NP_001307864.1  dystrobrevin beta isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC104699, AK294174, BC016655, DB460644
    UniProtKB/TrEMBL
    B7Z202
    Conserved Domains (3) summary
    cd02334
    Location:37 → 85
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:1 → 28
    EF-hand_3; EF-hand
    pfam13874
    Location:230 → 315
    Nup54; Nucleoporin complex subunit 54

  8. NM_001320936.2 → NP_001307865.1  dystrobrevin beta isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC012074, AF022728, DB460644
    UniProtKB/TrEMBL
    B7Z6A9
    Conserved Domains (5) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam04012
    Location:347 → 528
    PspA_IM30; PspA/IM30 family
    pfam09068
    Location:16 → 140
    EF-hand_2; EF hand
    pfam09069
    Location:144 → 232
    EF-hand_3; EF-hand
    pfam11068
    Location:438 → 525
    YlqD; YlqD protein

  9. NM_001320937.2 → NP_001307866.1  dystrobrevin beta isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC019144, AI608704, AL555818, DB460644
    Conserved Domains (2) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16244
    Location:54 → 214
    EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins

  10. NM_001351381.2 → NP_001338310.1  dystrobrevin beta isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    Conserved Domains (4) summary
    cd02334
    Location:94 → 142
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd15901
    Location:4 → 33
    EFh_DMD_DYTN_DTN; EF-hand-like motif [structural motif]
    cl07621
    Location:4 → 67
    EFh_DMD_DYTN_DTN; EF-hand-like motif found in the dystrophin/dystrobrevin/dystrotelin family
    cl25732
    Location:260 → 350
    SMC_N; RecF/RecN/SMC N terminal domain

  11. NM_001351382.2 → NP_001338311.1  dystrobrevin beta isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    UniProtKB/TrEMBL
    B7Z6A9
    Conserved Domains (3) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16244
    Location:54 → 214
    EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    cl25602
    Location:401 → 495
    DUF3552; Domain of unknown function (DUF3552)

  12. NM_001351383.2 → NP_001338312.1  dystrobrevin beta isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    UniProtKB/TrEMBL
    B7Z6A9
    Conserved Domains (3) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16244
    Location:54 → 214
    EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    cl25732
    Location:401 → 503
    SMC_N; RecF/RecN/SMC N terminal domain

  13. NM_001351384.2 → NP_001338313.1  dystrobrevin beta isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    UniProtKB/TrEMBL
    B7Z6A9
    Conserved Domains (3) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16244
    Location:54 → 214
    EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    cl27210
    Location:427 → 521
    Mnd1; Mnd1 family

  14. NM_001351385.2 → NP_001338314.1  dystrobrevin beta isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    UniProtKB/TrEMBL
    B7Z6A9
    Conserved Domains (2) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16244
    Location:54 → 214
    EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins

  15. NM_001351386.2 → NP_001338315.1  dystrobrevin beta isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    UniProtKB/TrEMBL
    B7Z6A9
    Conserved Domains (3) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16244
    Location:54 → 214
    EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    cl27210
    Location:397 → 491
    Mnd1; Mnd1 family

  16. NM_001351387.2 → NP_001338316.1  dystrobrevin beta isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    UniProtKB/TrEMBL
    B7Z6A9
    Conserved Domains (3) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16244
    Location:54 → 214
    EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    cl25732
    Location:401 → 503
    SMC_N; RecF/RecN/SMC N terminal domain

  17. NM_001351388.2 → NP_001338317.1  dystrobrevin beta isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    UniProtKB/TrEMBL
    B7Z6A9
    Conserved Domains (3) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16244
    Location:54 → 214
    EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    cl25602
    Location:431 → 525
    DUF3552; Domain of unknown function (DUF3552)

  18. NM_001351389.2 → NP_001338318.1  dystrobrevin beta isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC019144, AC104699
    Conserved Domains (3) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16244
    Location:54 → 214
    EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    cl25602
    Location:401 → 495
    DUF3552; Domain of unknown function (DUF3552)

  19. NM_001351390.2 → NP_001338319.1  dystrobrevin beta isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    UniProtKB/TrEMBL
    B7Z6A9
    Conserved Domains (3) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16244
    Location:54 → 214
    EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    cl25602
    Location:401 → 495
    DUF3552; Domain of unknown function (DUF3552)

  20. NM_001351391.2 → NP_001338320.1  dystrobrevin beta isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    UniProtKB/TrEMBL
    B7Z6A9
    Conserved Domains (3) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16244
    Location:54 → 214
    EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    cl27210
    Location:397 → 491
    Mnd1; Mnd1 family

  21. NM_001351392.2 → NP_001338321.1  dystrobrevin beta isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    Conserved Domains (4) summary
    cd02334
    Location:94 → 142
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd15901
    Location:4 → 33
    EFh_DMD_DYTN_DTN; EF-hand-like motif [structural motif]
    cl07621
    Location:4 → 67
    EFh_DMD_DYTN_DTN; EF-hand-like motif found in the dystrophin/dystrobrevin/dystrotelin family
    cl25723
    Location:257 → 346
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  22. NM_001351393.2 → NP_001338322.1  dystrobrevin beta isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    Conserved Domains (4) summary
    cd02334
    Location:94 → 142
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd15901
    Location:4 → 33
    EFh_DMD_DYTN_DTN; EF-hand-like motif [structural motif]
    cl07621
    Location:4 → 67
    EFh_DMD_DYTN_DTN; EF-hand-like motif found in the dystrophin/dystrobrevin/dystrotelin family
    cl25723
    Location:257 → 346
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

  23. NM_001351394.2 → NP_001338323.1  dystrobrevin beta isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    UniProtKB/TrEMBL
    B7Z6A9
    Conserved Domains (4) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16250
    Location:54 → 214
    EFh_DTNB; EF-hand-like motif found in beta-dystrobrevin
    cl25723
    Location:434 → 531
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cl25917
    Location:346 → 518
    Exonuc_VII_L; Exonuclease VII, large subunit

  24. NM_001351395.2 → NP_001338324.1  dystrobrevin beta isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    Conserved Domains (2) summary
    cl25732
    Location:10 → 216
    SMC_N; RecF/RecN/SMC N terminal domain
    cl27210
    Location:122 → 216
    Mnd1; Mnd1 family

  25. NM_001394686.1 → NP_001381615.1  dystrobrevin beta isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    Conserved Domains (4) summary
    COG1340
    Location:287 → 368
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    PRK00286
    Location:199 → 379
    xseA; exodeoxyribonuclease VII large subunit; Reviewed
    cd02334
    Location:94 → 142
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:4 → 85
    EF-hand_3

  26. NM_021907.5 → NP_068707.1  dystrobrevin beta isoform 1

    See identical proteins and their annotated locations for NP_068707.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF022728, DB460644
    Consensus CDS
    CCDS46237.1
    UniProtKB/Swiss-Prot
    B7Z733, F5GZG4, G5E9F6, O43782, O60881, O60941, O75538, Q86VR4, Q96AW0, Q9UE14, Q9UE15, Q9UE16
    UniProtKB/TrEMBL
    B7Z6A9
    Related
    ENSP00000384084.3, ENST00000406818.8
    Conserved Domains (4) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16 → 140
    EF-hand_2; EF hand
    pfam09069
    Location:144 → 232
    EF-hand_3; EF-hand
    pfam11068
    Location:438 → 525
    YlqD; YlqD protein

  27. NM_033147.4 → NP_149159.2  dystrobrevin beta isoform 2

    See identical proteins and their annotated locations for NP_149159.2

    Status: REVIEWED

    Source sequence(s)
    AF022728, BC016655, DB460644
    Consensus CDS
    CCDS46235.1
    UniProtKB/TrEMBL
    B7Z6A9
    Related
    ENSP00000385482.3, ENST00000404103.7
    Conserved Domains (4) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16 → 140
    EF-hand_2; EF hand
    pfam09069
    Location:144 → 232
    EF-hand_3; EF-hand
    pfam13874
    Location:434 → 517
    Nup54; Nucleoporin complex subunit 54

  28. NM_033148.4 → NP_149160.1  dystrobrevin beta isoform 3

    See identical proteins and their annotated locations for NP_149160.1

    Status: REVIEWED

    Source sequence(s)
    DB460644, Y12712
    Consensus CDS
    CCDS46234.1
    UniProtKB/TrEMBL
    B7Z6A9
    Related
    ENSP00000384767.3, ENST00000407038.7
    Conserved Domains (4) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16 → 140
    EF-hand_2; EF hand
    pfam09069
    Location:144 → 232
    EF-hand_3; EF-hand
    pfam13874
    Location:404 → 487
    Nup54; Nucleoporin complex subunit 54

  29. NM_183360.3 → NP_899204.1  dystrobrevin beta isoform 4

    See identical proteins and their annotated locations for NP_899204.1

    Status: REVIEWED

    Source sequence(s)
    BC016655, BC049366, DB460644, Y12712
    Consensus CDS
    CCDS46236.1
    UniProtKB/TrEMBL
    B7Z6A9
    Related
    ENSP00000385193.3, ENST00000407661.7
    Conserved Domains (4) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16 → 140
    EF-hand_2; EF hand
    pfam09069
    Location:144 → 232
    EF-hand_3; EF-hand
    pfam11068
    Location:438 → 525
    YlqD; YlqD protein

  30. NM_183361.3 → NP_899205.1  dystrobrevin beta isoform 5

    See identical proteins and their annotated locations for NP_899205.1

    Status: REVIEWED

    Source sequence(s)
    BC016655, DB460644
    Consensus CDS
    CCDS46233.1
    UniProtKB/TrEMBL
    B7Z6A9
    Related
    ENSP00000384787.1, ENST00000405222.5
    Conserved Domains (3) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16244
    Location:54 → 214
    EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    cl27210
    Location:397 → 491
    Mnd1; Mnd1 family

RNA

  1. NR_147180.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    Related
    ENST00000398951.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    25377243..25673577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    25412572..25708881 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O60941.1 GenPept UniProtKB/Swiss-Prot:O60941

Gene LinkOut

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