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Oprm1 opioid receptor, mu 1 [ Mus musculus (house mouse) ]

Gene ID: 18390, updated on 30-Nov-2021

Summary

Official Symbol
Oprm1provided by MGI
Official Full Name
opioid receptor, mu 1provided by MGI
Primary source
MGI:MGI:97441
See related
Ensembl:ENSMUSG00000000766
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mor; Oprm; muOR; MOP-R; MOR-1; M-OR-1; MOR-1O
Summary
This gene encodes the mu opioid receptor which is where drugs such as morphine and other opioids have pharmacological effects. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Oprm1 in Genome Data Viewer
Location:
10 A1; 10 1.85 cM
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (6708593..6988209)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (6758593..7038209)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (3308332..3557940, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene 3213 Neighboring gene tripartite motif-containing 59 pseudogene Neighboring gene interaction protein for cytohesin exchange factors 1 Neighboring gene Cnksr family member 3 Neighboring gene predicted gene, 53610

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled opioid receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables G-protein alpha-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G-protein beta-subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-endorphin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables beta-endorphin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables filamin binding ISO
Inferred from Sequence Orthology
more info
 
enables morphine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables morphine receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled opioid receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled opioid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adenylate cyclase-activating dopamine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-inhibiting opioid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in behavioral response to ethanol ISO
Inferred from Sequence Orthology
more info
 
involved_in eating behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within locomotory behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of Wnt protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of appetite ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of NMDA receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cellular response to stress ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ethanol ISO
Inferred from Sequence Orthology
more info
 
involved_in sensory perception of pain IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
colocalizes_with sarcolemma ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mu-type opioid receptor
Names
MOP receptor
mu opioid receptor MOR-1BI
mu opioid receptor MOR-1P
mu opioid receptor splice variant mMOR-1Z

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039652.2NP_001034741.1  mu-type opioid receptor isoform MOR-1C

    See identical proteins and their annotated locations for NP_001034741.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1C) lacks an exon in the 3' coding region, compared to variant MOR-1U. The resulting isoform (MOR-1C), is shorter than isoform MOR-1U.
    Source sequence(s)
    AC153981, AF062753, AK038389
    Consensus CDS
    CCDS56687.1
    UniProtKB/Swiss-Prot
    P42866
    Related
    ENSMUSP00000101236.2, ENSMUST00000105611.8
    Conserved Domains (2) summary
    pfam00001
    Location:85336
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:77281
    7tm_4; Olfactory receptor
  2. NM_001302793.1NP_001289722.1  mu-type opioid receptor isoform MOR-1

    See identical proteins and their annotated locations for NP_001289722.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1) lacks several 3' coding exons and contains an alternate 3' coding exon compared to variant MOR-1U. The resulting isoform (MOR-1) has a shorter and distinct C-terminus compared to isoform MOR-1U. This variant likely represents the major transcript of this gene.
    Source sequence(s)
    AC153981, AC164171, AF062753
    Consensus CDS
    CCDS78787.1
    UniProtKB/Swiss-Prot
    P42866
    Related
    ENSMUSP00000101232.2, ENSMUST00000105607.8
    Conserved Domains (1) summary
    cd15090
    Location:69347
    7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001302794.1NP_001289723.1  mu-type opioid receptor isoform MOR-1G

    See identical proteins and their annotated locations for NP_001289723.1

    Status: REVIEWED

    Description
    Transcript Variant: has an alternate exon in place of the 5'-most exon, lacks several 3' coding exons, and contains an alternate 3' coding exon compared to variant MOR-1U. The resulting isoform (MOR-1G) has shorter and distinct N- and C-termini compared to isoform MOR-1U.
    Source sequence(s)
    AC164171, AF062755
    Consensus CDS
    CCDS78783.1
    UniProtKB/Swiss-Prot
    P42866
    Related
    ENSMUSP00000117950.2, ENSMUST00000147171.8
    Conserved Domains (2) summary
    pfam00001
    Location:26268
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:24213
    7tm_4; Olfactory receptor
  4. NM_001302795.1NP_001289724.1  mu-type opioid receptor isoform MOR-1M

    See identical proteins and their annotated locations for NP_001289724.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1M) has an alternate exon in place of the 5'-most exon compared to MOR-1U. The resulting isoform (MOR-1M) has a shorter and distinct N-terminus compared to isoform MOR-1U.
    Source sequence(s)
    AF062755, AK038389
    Consensus CDS
    CCDS78784.1
    UniProtKB/Swiss-Prot
    P42866
    Related
    ENSMUSP00000101240.3, ENSMUST00000105615.9
    Conserved Domains (2) summary
    pfam00001
    Location:26268
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:24213
    7tm_4; Olfactory receptor
  5. NM_001302796.1NP_001289725.1  mu-type opioid receptor isoform MOR-1N

    See identical proteins and their annotated locations for NP_001289725.1

    Status: REVIEWED

    Description
    Transcript Variant: has an alternate exon in place of the 5'-most exon and lacks an alternate 3' coding exon compared to variant MOR-1U. The resulting isoform (MOR-1N) has shorter and distinct N- and C-termini compared to isoform MOR-1U.
    Source sequence(s)
    AF062755, AK038389
    Consensus CDS
    CCDS78785.1
    UniProtKB/Swiss-Prot
    P42866
    Related
    ENSMUSP00000053498.8, ENSMUST00000063036.14
    Conserved Domains (2) summary
    pfam00001
    Location:26268
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:24213
    7tm_4; Olfactory receptor
  6. NM_001304937.1NP_001291866.1  mu-type opioid receptor isoform MOR-1A

    See identical proteins and their annotated locations for NP_001291866.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1A) lacks 3' exons and its 3' terminal exon extends past a splice site that is used in variant MOR-1U. It encodes isoform MOR-1A which is shorter and has a distinct C-terminus, compared to isoform MOR-1U.
    Source sequence(s)
    AC153981
    Consensus CDS
    CCDS83674.1
    UniProtKB/Swiss-Prot
    P42866
    Related
    ENSMUSP00000101227.2, ENSMUST00000105602.8
    Conserved Domains (2) summary
    pfam00001
    Location:85336
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:77281
    7tm_4; Olfactory receptor
  7. NM_001304938.1NP_001291867.1  mu-type opioid receptor isoform MOR-1B1

    See identical proteins and their annotated locations for NP_001291867.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1B1) lacks 3' exons and includes an alternate penultimate exon, compared to variant MOR-1U, resulting in a novel 3' coding region and 3' UTR. It encodes isoform MOR-1B1 which has a distinct C-terminus, compared to isoform MOR-1U.
    Source sequence(s)
    AC153981, AC164171
    Consensus CDS
    CCDS83673.1
    UniProtKB/Swiss-Prot
    P42866
    Related
    ENSMUSP00000101230.2, ENSMUST00000105605.8
    Conserved Domains (1) summary
    cd15090
    Location:69347
    7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
  8. NM_001304948.1NP_001291877.1  mu-type opioid receptor isoform MOR-1B2

    See identical proteins and their annotated locations for NP_001291877.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1B2) lacks 3' exons and includes an alternate penultimate exon, compared to variant MOR-1U, resulting in a novel 3' coding region and 3' UTR. It encodes isoform MOR-1B1 which has a distinct C-terminus, compared to isoform MOR-1U.
    Source sequence(s)
    AC153981, AC164171
    Consensus CDS
    CCDS83672.1
    UniProtKB/Swiss-Prot
    P42866
    Related
    ENSMUSP00000114342.2, ENSMUST00000154906.8
    Conserved Domains (2) summary
    pfam00001
    Location:85336
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:77281
    7tm_4; Olfactory receptor
  9. NM_001304950.1NP_001291879.1  mu-type opioid receptor isoform MOR-1D

    See identical proteins and their annotated locations for NP_001291879.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1D) differs in the 3' UTR and has multiple coding region differences, compared to variant MOR-1U, one of which results in a frameshift. The resulting protein (isoform MOR-1D) has a distinct C-terminus and is shorter than isoform MOR-1U.
    Source sequence(s)
    AC153981, AC155718
    Consensus CDS
    CCDS78788.1
    UniProtKB/Swiss-Prot
    P42866
    Related
    ENSMUSP00000060329.8, ENSMUST00000052751.14
    Conserved Domains (2) summary
    pfam00001
    Location:85336
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:77281
    7tm_4; Olfactory receptor
  10. NM_001304955.1NP_001291884.1  mu-type opioid receptor isoform MOR-1U

    See identical proteins and their annotated locations for NP_001291884.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MOR-1U) encodes the longest isoform (MOR-1U).
    Source sequence(s)
    AC153981, AC155718
    UniProtKB/Swiss-Prot
    P42866
    Conserved Domains (2) summary
    pfam00001
    Location:85336
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:77281
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    6708593..6988209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512437.5XP_006512500.1  mu-type opioid receptor isoform X1

    Conserved Domains (1) summary
    cd15090
    Location:69347
    7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_017313827.3XP_017169316.1  mu-type opioid receptor isoform X3

    UniProtKB/Swiss-Prot
    P42866
    Related
    ENSMUSP00000000783.7, ENSMUST00000000783.13
    Conserved Domains (1) summary
    cd15090
    Location:69347
    7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_017313826.3XP_017169315.1  mu-type opioid receptor isoform X2

    UniProtKB/Swiss-Prot
    P42866
    UniProtKB/TrEMBL
    A0A0R4J0Z2
    Related
    ENSMUSP00000077704.6, ENSMUST00000078634.12
    Conserved Domains (1) summary
    cd15090
    Location:69347
    7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. XM_017313828.1XP_017169317.1  mu-type opioid receptor isoform X4

    UniProtKB/TrEMBL
    A1KZZ4
    Related
    ENSMUSP00000120187.2, ENSMUST00000123861.8
    Conserved Domains (2) summary
    cd14964
    Location:7195
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:69100
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  5. XM_017313829.2XP_017169318.1  mu-type opioid receptor isoform X5

    Conserved Domains (2) summary
    cd14964
    Location:7096
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:6996
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_011013.1: Suppressed sequence

    Description
    NM_011013.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
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