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Otc ornithine transcarbamylase [ Mus musculus (house mouse) ]

Gene ID: 18416, updated on 23-Jun-2021

Summary

Official Symbol
Otcprovided by MGI
Official Full Name
ornithine transcarbamylaseprovided by MGI
Primary source
MGI:MGI:97448
See related
Ensembl:ENSMUSG00000031173
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sf; spf; AI265390
Expression
Biased expression in liver adult (RPKM 25.6), liver E18 (RPKM 13.3) and 6 other tissues See more
Orthologs
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Genomic context

See Otc in Genome Data Viewer
Location:
X A1.1; X 4.66 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (10118500..10187263)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (10252230..10321024)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (9829485..9898150)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 33844 Neighboring gene retinitis pigmentosa GTPase regulator Neighboring gene predicted gene, 54080 Neighboring gene ferritin light chain pseudogene Neighboring gene predicted gene, 54081

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (2)  1 citation
  • Targeted (1)  1 citation
  • Radiation induced (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amino acid binding ISO
Inferred from Sequence Orthology
more info
 
enables carboxyl- or carbamoyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ornithine carbamoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ornithine carbamoyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphate ion binding ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ammonium homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in anion homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within arginine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in arginine biosynthetic process via ornithine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cellular amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in citrulline biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in citrulline biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in ornithine catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in ornithine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in urea cycle ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ornithine transcarbamylase, mitochondrial; ornithine carbamoyltransferase, mitochondrial
Names
OTCase
NP_032795.1
XP_011245751.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008769.4NP_032795.1  ornithine transcarbamylase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_032795.1

    Status: VALIDATED

    Source sequence(s)
    AK050930, AL671042, BY090290
    Consensus CDS
    CCDS30015.1
    UniProtKB/Swiss-Prot
    P11725
    UniProtKB/TrEMBL
    Q543H3
    Related
    ENSMUSP00000056152.7, ENSMUST00000049910.13
    Conserved Domains (3) summary
    PRK00779
    Location:36342
    PRK00779; ornithine carbamoyltransferase; Provisional
    pfam00185
    Location:188341
    OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
    pfam02729
    Location:41181
    OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    10118500..10187263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247449.4XP_011245751.1  ornithine carbamoyltransferase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011245751.1

    UniProtKB/TrEMBL
    Q8R1A8
    Related
    ENSMUSP00000111190.3, ENSMUST00000115528.3
    Conserved Domains (1) summary
    PRK00779
    Location:36330
    PRK00779; ornithine carbamoyltransferase; Provisional
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