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P2rx4 purinergic receptor P2X, ligand-gated ion channel 4 [ Mus musculus (house mouse) ]

Gene ID: 18438, updated on 14-Oct-2021

Summary

Official Symbol
P2rx4provided by MGI
Official Full Name
purinergic receptor P2X, ligand-gated ion channel 4provided by MGI
Primary source
MGI:MGI:1338859
See related
Ensembl:ENSMUSG00000029470
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P2X4; AI504491; AW555605; D5Ertd444e
Expression
Ubiquitous expression in colon adult (RPKM 57.8), lung adult (RPKM 28.0) and 23 other tissues See more
Orthologs
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Genomic context

See P2rx4 in Genome Data Viewer
Location:
5 F; 5 62.53 cM
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (122845581..122867802)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (122707518..122729739)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (123157566..123179053)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 7 Neighboring gene microRNA 8115 Neighboring gene predicted gene 10064 Neighboring gene calcium/calmodulin-dependent protein kinase kinase 2, beta Neighboring gene anaphase-promoting complex subunit 5 Neighboring gene predicted gene, 33044

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
 
enables copper ion binding ISO
Inferred from Sequence Orthology
more info
 
enables extracellularly ATP-gated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables extracellularly ATP-gated cation channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables extracellularly ATP-gated cation channel activity ISO
Inferred from Sequence Orthology
more info
 
enables extracellularly ATP-gated cation channel activity TAS
Traceable Author Statement
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables ligand-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables purinergic nucleotide receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in behavioral response to pain ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to ATP ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to zinc ion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inorganic cation transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
involved_in neuronal action potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nitric oxide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion transport into cytosol ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of microglial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in purinergic nucleotide receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in relaxation of cardiac muscle ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ATP ISO
Inferred from Sequence Orthology
more info
 
involved_in response to axon injury ISO
Inferred from Sequence Orthology
more info
 
involved_in response to fluid shear stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ischemia ISO
Inferred from Sequence Orthology
more info
 
involved_in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in sensory perception of touch ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within vasodilation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
P2X purinoceptor 4
Names
ionotropic purinergic receptor
purinergic receptor P2x4 subunit variant e

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310718.1NP_001297647.1  P2X purinoceptor 4 isoform 2

    See identical proteins and their annotated locations for NP_001297647.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC115728, AK162820, BM244734, BY150918, JX417451
    Consensus CDS
    CCDS80392.1
    UniProtKB/TrEMBL
    D3Z5U5
    Related
    ENSMUSP00000117193.3, ENSMUST00000142664.3
    Conserved Domains (1) summary
    pfam00864
    Location:13339
    P2X_receptor; ATP P2X receptor
  2. NM_001310720.1NP_001297649.1  P2X purinoceptor 4 isoform 3

    See identical proteins and their annotated locations for NP_001297649.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC115728, AF089752, AK162820, BM244734, BY150918
    Consensus CDS
    CCDS80393.1
    UniProtKB/TrEMBL
    Q9Z256
    Related
    ENSMUSP00000080269.7, ENSMUST00000081554.13
    Conserved Domains (1) summary
    pfam00864
    Location:13334
    P2X_receptor; ATP P2X receptor
  3. NM_011026.3NP_035156.2  P2X purinoceptor 4 isoform 1

    See identical proteins and their annotated locations for NP_035156.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC115728, AF089751, AK162820, BM244734, BY150918
    Consensus CDS
    CCDS19654.2
    UniProtKB/TrEMBL
    Q9Z257
    Related
    ENSMUSP00000031429.8, ENSMUST00000031429.14
    Conserved Domains (1) summary
    pfam00864
    Location:13361
    P2X_receptor; ATP P2X receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    122845581..122867802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530196.4XP_006530259.1  P2X purinoceptor 4 isoform X1

    UniProtKB/TrEMBL
    D3YYR5
    Related
    ENSMUSP00000118163.3, ENSMUST00000139631.8
    Conserved Domains (1) summary
    cl02993
    Location:1312
    P2X_receptor; ATP P2X receptor
  2. XM_036164869.1XP_036020762.1  P2X purinoceptor 4 isoform X2

    Conserved Domains (1) summary
    pfam00864
    Location:1233
    P2X_receptor; ATP P2X receptor
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