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Pafah1b3 platelet-activating factor acetylhydrolase, isoform 1b, subunit 3 [ Mus musculus (house mouse) ]

Gene ID: 18476, updated on 23-Jun-2021

Summary

Official Symbol
Pafah1b3provided by MGI
Official Full Name
platelet-activating factor acetylhydrolase, isoform 1b, subunit 3provided by MGI
Primary source
MGI:MGI:108414
See related
Ensembl:ENSMUSG00000005447
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Paf; mus[g; Pafahg; mus[g]
Expression
Broad expression in whole brain E14.5 (RPKM 110.4), CNS E14 (RPKM 96.3) and 24 other tissues See more
Orthologs
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Genomic context

See Pafah1b3 in Genome Data Viewer
Location:
7; 7 A3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24994473..24997411, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25295048..25297986, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (26080068..26082974, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53354 Neighboring gene predicted gene, 45974 Neighboring gene capicua transcriptional repressor Neighboring gene proline rich 19 Neighboring gene transmembrane protein 145

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables platelet-activating factor acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to platelet-activating factor acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within spermatogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of 1-alkyl-2-acetylglycerophosphocholine esterase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
platelet-activating factor acetylhydrolase IB subunit alpha1; platelet-activating factor acetylhydrolase IB subunit gamma
Names
PAF acetylhydrolase 29 kDa subunit
PAF-AH 29 kDa subunit
PAF-AH gamma
PAF-AH subunit gamma
PAFAH subunit gamma
NP_001344279.1
NP_032802.1
XP_017177516.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357350.1NP_001344279.1  platelet-activating factor acetylhydrolase IB subunit alpha1

    Status: VALIDATED

    Source sequence(s)
    AC156992
    Consensus CDS
    CCDS20979.1
    Conserved Domains (1) summary
    cd01820
    Location:8206
    PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
  2. NM_008776.2NP_032802.1  platelet-activating factor acetylhydrolase IB subunit alpha1

    See identical proteins and their annotated locations for NP_032802.1

    Status: VALIDATED

    Source sequence(s)
    AC156992, BC067015
    Consensus CDS
    CCDS20979.1
    UniProtKB/Swiss-Prot
    Q61205
    UniProtKB/TrEMBL
    Q3TJC2
    Related
    ENSMUSP00000005583.6, ENSMUST00000005583.12
    Conserved Domains (1) summary
    cd01820
    Location:8206
    PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    24994473..24997411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322027.2XP_017177516.1  platelet-activating factor acetylhydrolase IB subunit gamma isoform X1

    UniProtKB/Swiss-Prot
    Q61205
    UniProtKB/TrEMBL
    Q3TJC2
    Conserved Domains (1) summary
    cd01820
    Location:8206
    PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...
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