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Cntn3 contactin 3 [ Mus musculus (house mouse) ]

Gene ID: 18488, updated on 5-Mar-2024

Summary

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Official Symbol
Cntn3provided by MGI
Official Full Name
contactin 3provided by MGI
Primary source
MGI:MGI:99534
See related
Ensembl:ENSMUSG00000030075 AllianceGenome:MGI:99534
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pang
Summary
Predicted to be involved in nervous system development. Predicted to act upstream of or within cell adhesion. Predicted to be located in plasma membrane. Predicted to be anchored component of membrane. Predicted to be active in neuron projection. Is expressed in several structures, including alimentary system; ear; genitourinary system; integumental system; and nervous system. Orthologous to human CNTN3 (contactin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 2.4), CNS E18 (RPKM 1.4) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 D3; 6 47.52 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (102140265..102541575, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (102163304..102564614, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16891 Neighboring gene predicted gene 9871 Neighboring gene STARR-seq mESC enhancer starr_16892 Neighboring gene STARR-seq mESC enhancer starr_16893 Neighboring gene STARR-seq mESC enhancer starr_16894 Neighboring gene STARR-seq mESC enhancer starr_16895 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene RIKEN cDNA 4930587E11 gene Neighboring gene STARR-seq mESC enhancer starr_16896 Neighboring gene STARR-seq mESC enhancer starr_16897 Neighboring gene predicted gene, 38870 Neighboring gene STARR-seq mESC enhancer starr_16898 Neighboring gene STARR-seq mESC enhancer starr_16902 Neighboring gene STARR-seq mESC enhancer starr_16903 Neighboring gene STARR-seq mESC enhancer starr_16904 Neighboring gene STARR-seq mESC enhancer starr_16907 Neighboring gene STARR-seq mESC enhancer starr_16908 Neighboring gene STARR-seq mESC enhancer starr_16909 Neighboring gene STARR-seq mESC enhancer starr_16910 Neighboring gene STARR-seq mESC enhancer starr_16911 Neighboring gene microRNA 6373 Neighboring gene predicted gene, 26022

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Defining the binding interface of Amyloid Precursor Protein (APP) and Contactin3 (CNTN3) by site-directed mutagenesis. Peng X, et al. PLoS One, 2019. PMID 31318883, Free PMC Article
  2. PANG, a gene encoding a neuronal glycoprotein, is ectopically activated by intracisternal A-type particle long terminal repeats in murine plasmacytomas. Connelly MA, et al. Proc Natl Acad Sci U S A, 1994 Feb 15. PMID 8108413, Free PMC Article
  3. BIG-1: a new TAG-1/F3-related member of the immunoglobulin superfamily with neurite outgrowth-promoting activity. Yoshihara Y, et al. Neuron, 1994 Aug. PMID 8060619
  4. Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues. Nikolaienko RM, et al. J Biol Chem, 2016 Oct 7. PMID 27539848, Free PMC Article
  5. The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules. Bouyain S, et al. Proc Natl Acad Sci U S A, 2010 Feb 9. PMID 20133774, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These experiments define the regions of direct contact that mediate the binding interaction between APP and CNTN3.
    Title: Defining the binding interface of Amyloid Precursor Protein (APP) and Contactin3 (CNTN3) by site-directed mutagenesis.
  2. Protein-tyrosine phosphatase receptor type G (RPTPgamma/PTPRG) interacts in vitro with contactin-3-6 (CNTN3-6), a group of glycophosphatidylinositol-anchored cell adhesion molecules involved in the wiring of the nervous system
    Title: Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
contactin-3
Names
BIG-1
brain-derived immunoglobulin superfamily protein 1
plasmacytoma-associated neuronal glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008779.3 → NP_032805.2  contactin-3 precursor

    See identical proteins and their annotated locations for NP_032805.2

    Status: VALIDATED

    Source sequence(s)
    AC114423, AC153597, AC153600, AC155328
    Consensus CDS
    CCDS39581.1
    UniProtKB/Swiss-Prot
    G5E878, Q07409
    Related
    ENSMUSP00000032159.7, ENSMUST00000032159.7
    Conserved Domains (3) summary
    cd00063
    Location:598 → 695
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:498 → 504
    Ig; Ig strand A [structural motif]
    cl11960
    Location:498 → 598
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    102140265..102541575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505729.5 → XP_006505792.1  contactin-3 isoform X2

    Conserved Domains (2) summary
    cd00063
    Location:598 → 695
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:227 → 315
    Ig; Immunoglobulin domain

  2. XM_006505727.5 → XP_006505790.1  contactin-3 isoform X1

    See identical proteins and their annotated locations for XP_006505790.1

    UniProtKB/Swiss-Prot
    G5E878, Q07409
    Conserved Domains (3) summary
    cd00063
    Location:598 → 695
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:498 → 504
    Ig; Ig strand A [structural motif]
    cl11960
    Location:498 → 598
    Ig; Immunoglobulin domain

  3. XM_036165925.1 → XP_036021818.1  contactin-3 isoform X1

    UniProtKB/Swiss-Prot
    G5E878, Q07409
    Conserved Domains (3) summary
    cd00063
    Location:598 → 695
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:498 → 504
    Ig; Ig strand A [structural motif]
    cl11960
    Location:498 → 598
    Ig; Immunoglobulin domain

  4. XM_006505728.5 → XP_006505791.1  contactin-3 isoform X1

    See identical proteins and their annotated locations for XP_006505791.1

    UniProtKB/Swiss-Prot
    G5E878, Q07409
    Conserved Domains (3) summary
    cd00063
    Location:598 → 695
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:498 → 504
    Ig; Ig strand A [structural motif]
    cl11960
    Location:498 → 598
    Ig; Immunoglobulin domain

  5. XM_011241248.3 → XP_011239550.1  contactin-3 isoform X3

    Conserved Domains (2) summary
    cd00063
    Location:471 → 568
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:100 → 188
    Ig; Immunoglobulin domain

RNA

  1. XR_001785107.3 RNA Sequence

  2. XR_377430.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07409.2 GenPept UniProtKB/Swiss-Prot:Q07409

Gene LinkOut

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