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Pbx3 pre B cell leukemia homeobox 3 [ Mus musculus (house mouse) ]

Gene ID: 18516, updated on 23-Jun-2021

Summary

Official Symbol
Pbx3provided by MGI
Official Full Name
pre B cell leukemia homeobox 3provided by MGI
Primary source
MGI:MGI:97496
See related
Ensembl:ENSMUSG00000038718
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Broad expression in whole brain E14.5 (RPKM 32.9), CNS E14 (RPKM 31.9) and 21 other tissues See more
Orthologs
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Genomic context

See Pbx3 in Genome Data Viewer
Location:
2 B; 2 22.84 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (34061469..34262375, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (34171457..34372045, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (34027429..34227556, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39793 Neighboring gene predicted gene 13404 Neighboring gene RIKEN cDNA C230014O12 gene Neighboring gene predicted gene, 54111 Neighboring gene mitogen-activated protein kinase associated protein 1 Neighboring gene ribosomal protein S7 pseudogene Neighboring gene predicted gene, 34178 Neighboring gene ribosomal protein S3A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pre-B-cell leukemia transcription factor 3
Names
homeobox protein PBX3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290576.1NP_001277505.1  pre-B-cell leukemia transcription factor 3 isoform PBX3b

    See identical proteins and their annotated locations for NP_001277505.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant a. The encoded isoform (PBX3b) has a distinct C-terminus and is shorter than isoform PBX3a.
    Source sequence(s)
    AF020200, AW123376, BF463864
    Consensus CDS
    CCDS71033.1
    UniProtKB/Swiss-Prot
    O35317
    Related
    ENSMUSP00000108757.3, ENSMUST00000113132.9
    Conserved Domains (2) summary
    cd00086
    Location:236296
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam03792
    Location:43234
    PBC; PBC domain
  2. NM_016768.2NP_058048.1  pre-B-cell leukemia transcription factor 3 isoform PBX3a

    See identical proteins and their annotated locations for NP_058048.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) represents the longer transcript and encodes the longer isoform (PBX3a).
    Source sequence(s)
    AF020199, AF020200, AW123376, BF463864
    Consensus CDS
    CCDS15947.1
    UniProtKB/Swiss-Prot
    O35317
    Related
    ENSMUSP00000045281.8, ENSMUST00000040638.15
    Conserved Domains (2) summary
    cd00086
    Location:236296
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam03792
    Location:43234
    PBC; PBC domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    34061469..34262375 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497784.2XP_006497847.1  pre-B-cell leukemia transcription factor 3 isoform X3

    Conserved Domains (2) summary
    cd00086
    Location:55115
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam03792
    Location:153
    PBC; PBC domain
  2. XM_006497782.3XP_006497845.1  pre-B-cell leukemia transcription factor 3 isoform X1

    See identical proteins and their annotated locations for XP_006497845.1

    Conserved Domains (2) summary
    cd00086
    Location:161221
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam03792
    Location:1159
    PBC; PBC domain
  3. XM_036159522.1XP_036015415.1  pre-B-cell leukemia transcription factor 3 isoform X3

    Conserved Domains (2) summary
    cd00086
    Location:55115
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam03792
    Location:153
    PBC; PBC domain
  4. XM_030248420.2XP_030104280.1  pre-B-cell leukemia transcription factor 3 isoform X2

    Conserved Domains (2) summary
    cd00086
    Location:161221
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam03792
    Location:1159
    PBC; PBC domain
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