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Pcdh10 protocadherin 10 [ Mus musculus (house mouse) ]

Gene ID: 18526, updated on 11-Apr-2024

Summary

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Official Symbol
Pcdh10provided by MGI
Official Full Name
protocadherin 10provided by MGI
Primary source
MGI:MGI:1338042
See related
Ensembl:ENSMUSG00000049100 AllianceGenome:MGI:1338042
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Olpc; OL-pc; mKIAA1400; 6430521D13Rik; 6430703F07Rik
Summary
Acts upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be integral component of plasma membrane. Is expressed in central nervous system; dorsal root ganglion; genitourinary system; jaw bone; and rib. Orthologous to human PCDH10 (protocadherin 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 11.6), CNS E18 (RPKM 9.9) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Pcdh10 in Genome Data Viewer
Location:
3 B; 3 20.35 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (45332833..45389014)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (45378398..45434579)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 882 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07541 Neighboring gene STARR-seq mESC enhancer starr_07542 Neighboring gene RIKEN cDNA 2610316D01 gene Neighboring gene STARR-seq mESC enhancer starr_07543 Neighboring gene STARR-seq mESC enhancer starr_07544 Neighboring gene RIKEN cDNA 1700027H10 gene Neighboring gene STARR-seq mESC enhancer starr_07545 Neighboring gene predicted gene, 32340 Neighboring gene predicted gene, 25796 Neighboring gene predicted gene, 32416

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Age- and sex-specific fear conditioning deficits in mice lacking Pcdh10, an Autism Associated Gene. Ferri SL, et al. Neurobiol Learn Mem, 2021 Feb. PMID 33340671, Free PMC Article
  2. Reorganization of longitudinal compartments in the laterally protruding paraflocculus of the postnatal mouse cerebellum. Panezai SK, et al. J Comp Neurol, 2020 Jul. PMID 31891184
  3. Cerebellar modules in the olivo-cortico-nuclear loop demarcated by pcdh10 expression in the adult mouse. Sarpong GA, et al. J Comp Neurol, 2018 Oct 15. PMID 30004589
  4. Protocadherin 10 alters γ oscillations, amino acid levels, and their coupling; baclofen partially restores these oscillatory deficits. Port RG, et al. Neurobiol Dis, 2017 Dec. PMID 28844789
  5. The importance of pre-clinical studies in animal models of TTR amyloidosis for the discovery of novel patient disease biomarkers. Gonçalves NP, et al. Amyloid, 2017 Mar. PMID 28434291

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Miz1 promotes KRAS-driven lung tumorigenesis by repressing the protocadherin Pcdh10.
    Title: Miz1 promotes KRAS-driven lung tumorigenesis by repressing the protocadherin Pcdh10.
  2. Age- and sex-specific fear conditioning deficits in mice lacking Pcdh10, an Autism Associated Gene.
    Title: Age- and sex-specific fear conditioning deficits in mice lacking Pcdh10, an Autism Associated Gene.
  3. Olivocerebellar and corticonuclear axonal labeling confirmed that the three cortical pcdh10-positive areas were topographically connected to the nuclear and olivary pcdh10-positive areas, demonstrating their coincidence with modular structures in the olivo-cortico-nuclear loop
    Title: Cerebellar modules in the olivo-cortico-nuclear loop demarcated by pcdh10 expression in the adult mouse.
  4. Comparative semi-quantitative Pcdh 10 immunohistochemistry of the brains of human V30M transgenics did not show significant staining as peripheral nerve did, emphasizing the specificity of Pcdh 10 in peripheral nerve of amyloidogenic V30M transgenics.
    Title: The importance of pre-clinical studies in animal models of TTR amyloidosis for the discovery of novel patient disease biomarkers.
  5. male Pcdh10(+/-) mice exhibited reduced gamma-band (30-80Hz), but not lower frequency (10 and 20Hz), auditory steady state responses (ASSR). In addition, male Pcdh10(+/-) mice exhibited decreased signal-to-noise-ratio (SNR) for high gamma-band (60-100Hz) activity. Administration of a GABAB agonist remediated these electrophysiological alterations among male Pcdh10(+/-)mice.
    Title: Protocadherin 10 alters γ oscillations, amino acid levels, and their coupling; baclofen partially restores these oscillatory deficits.
  6. Studies reveals that male Pcdh10(+/-) mice have synaptic and behavioral deficits, and establish Pcdh10(+/-) mice as a novel genetic model for investigating neural circuitry and behavioral changes relevant to autism spectrum disorder.
    Title: Sociability Deficits and Altered Amygdala Circuits in Mice Lacking Pcdh10, an Autism Associated Gene.
  7. Pcdh10, which is regulated by Pou3f1 and Hoxa5, is a mediator of like-like clustering of motor neuron cell bodies in the developing phrenic nerve.
    Title: Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons.
  8. The role of OL-protocadherin-dependent striatal axon growth in neural circuit formation.
    Title: Pioneers in the ventral telencephalon: The role of OL-protocadherin-dependent striatal axon growth in neural circuit formation.
  9. results show that OL-pc is essential for both elongation of striatal axons and patterning of the putative guidance cues for thalamocortical projections.
    Title: OL-Protocadherin is essential for growth of striatal axons and thalamocortical projections.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protocadherin-10
Names
OL-protocadherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098170.1 → NP_001091640.1  protocadherin-10 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK038615, AK046814, BC037259
    Consensus CDS
    CCDS50903.1
    UniProtKB/TrEMBL
    E9PXQ7, Q80TE2
    Related
    ENSMUSP00000131073.2, ENSMUST00000166126.7
    Conserved Domains (3) summary
    cd11304
    Location:254 → 354
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08266
    Location:19 → 101
    Cadherin_2; Cadherin-like
    pfam16492
    Location:713 → 838
    Cadherin_C_2; Cadherin cytoplasmic C-terminal

  2. NM_001098171.1 → NP_001091641.1  protocadherin-10 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001091641.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has a distinct 3' UTR and contains an alternate 3' coding exon, as compared to variant 1. The resulting protein (isoform 3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK032337, AK034005, AK045707, AK122503, BC037259
    Consensus CDS
    CCDS50902.1
    UniProtKB/TrEMBL
    Q80TE2, Q925I8
    Related
    ENSMUSP00000132769.2, ENSMUST00000170695.4
    Conserved Domains (3) summary
    cd11304
    Location:254 → 354
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08266
    Location:19 → 101
    Cadherin_2; Cadherin-like
    pfam16492
    Location:713 → 838
    Cadherin_C_2; Cadherin cytoplasmic C-terminal

  3. NM_001098172.1 → NP_001091642.1  protocadherin-10 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a distinct 3' UTR and contains an alternate 3' coding exon, as compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA386527, AK081977, BC037259
    Consensus CDS
    CCDS50901.1
    UniProtKB/TrEMBL
    E9PX28, Q80TE2
    Related
    ENSMUSP00000131600.2, ENSMUST00000171554.8
    Conserved Domains (3) summary
    cd11304
    Location:254 → 354
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08266
    Location:19 → 101
    Cadherin_2; Cadherin-like
    pfam16492
    Location:713 → 838
    Cadherin_C_2; Cadherin cytoplasmic C-terminal

  4. NM_011043.3 → NP_035173.2  protocadherin-10 isoform 4 precursor

    See identical proteins and their annotated locations for NP_035173.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) is unspliced, and so it has a distinct 3' UTR and lacks several 3' coding exons, as compared to variant 1. The resulting protein (isoform 4) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC037259, BC065695
    Consensus CDS
    CCDS79902.1
    UniProtKB/TrEMBL
    Q6P0A6, Q9Z1B1
    Related
    ENSMUSP00000141529.2, ENSMUST00000193252.2
    Conserved Domains (3) summary
    cd11304
    Location:254 → 354
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08266
    Location:19 → 101
    Cadherin_2; Cadherin-like
    pfam16492
    Location:713 → 838
    Cadherin_C_2; Cadherin cytoplasmic C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    45332833..45389014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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