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Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic [ Mus musculus (house mouse) ]

Gene ID: 18534, updated on 23-Jun-2021

Summary

Official Symbol
Pck1provided by MGI
Official Full Name
phosphoenolpyruvate carboxykinase 1, cytosolicprovided by MGI
Primary source
MGI:MGI:97501
See related
Ensembl:ENSMUSG00000027513
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PEP; Pck-; PEPCK; Pck-1; PEPCK-C; AI265463
Expression
Biased expression in kidney adult (RPKM 295.2), liver adult (RPKM 158.6) and 6 other tissues See more
Orthologs
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Genomic context

See Pck1 in Genome Data Viewer
Location:
2 H3; 2 95.79 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (172994866..173001067)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (173153073..173159274)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (172978574..172984755)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 40011 Neighboring gene CCCTC-binding factor (zinc finger protein)-like, opposite strand Neighboring gene predicted gene, 36691 Neighboring gene predicted gene, 36749 Neighboring gene Z-DNA binding protein 1 Neighboring gene prostate transmembrane protein, androgen induced 1 Neighboring gene prostate transmembrane protein, androgen induced 1, opposite strand

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables carboxylic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables manganese ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleoside diphosphate kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoenolpyruvate carboxykinase (GTP) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphoenolpyruvate carboxykinase (GTP) activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phosphoenolpyruvate carboxykinase (GTP) activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphoenolpyruvate carboxykinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phosphoenolpyruvate carboxykinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine kinase activity (using GTP as donor) ISO
Inferred from Sequence Orthology
more info
 
enables purine nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular response to dexamethasone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to glucose stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to potassium ion starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within gluconeogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glycerol biosynthetic process from pyruvate IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within glycerol biosynthetic process from pyruvate IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glycerol biosynthetic process from pyruvate ISO
Inferred from Sequence Orthology
more info
 
involved_in hepatocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oxaloacetate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oxaloacetate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of memory T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription from RNA polymerase II promoter in response to acidic pH IDA
Inferred from Direct Assay
more info
PubMed 
involved_in propionate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to insulin ISO
Inferred from Sequence Orthology
more info
 
involved_in response to lipid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
phosphoenolpyruvate carboxykinase, cytosolic [GTP]
Names
phosphoenolpyruvate carboxykinase, cytosolic
phosphoenolpyruvate carboxylase
serine-protein kinase PCK1
NP_035174.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011044.3NP_035174.1  phosphoenolpyruvate carboxykinase, cytosolic [GTP]

    See identical proteins and their annotated locations for NP_035174.1

    Status: VALIDATED

    Source sequence(s)
    AL837509
    Consensus CDS
    CCDS17141.1
    UniProtKB/Swiss-Prot
    Q9Z2V4
    Related
    ENSMUSP00000029017.6, ENSMUST00000029017.6
    Conserved Domains (1) summary
    cd00819
    Location:27615
    PEPCK_GTP; Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    172994866..173001067
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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