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Pde1c phosphodiesterase 1C [ Mus musculus (house mouse) ]

Gene ID: 18575, updated on 5-Jan-2022

Summary

Official Symbol
Pde1cprovided by MGI
Official Full Name
phosphodiesterase 1Cprovided by MGI
Primary source
MGI:MGI:108413
See related
Ensembl:ENSMUSG00000004347
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable cAMP binding activity; calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; and calmodulin-dependent cyclic-nucleotide phosphodiesterase activity. Acts upstream of or within sensory perception of smell. Located in cilium. Is expressed in several structures, including alimentary system; integumental system; male reproductive gland or organ; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 74. Orthologous to human PDE1C (phosphodiesterase 1C). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in testis adult (RPKM 4.7), cerebellum adult (RPKM 3.2) and 8 other tissues See more
Orthologs
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Genomic context

See Pde1c in Genome Data Viewer
Location:
6 B3; 6 27.65 cM
Exon count:
28
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (56046783..56629494, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (56069798..56652510, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (56019798..56319628, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 17 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene predicted gene, 34753 Neighboring gene predicted gene, 24709 Neighboring gene predicted gene, 22493 Neighboring gene LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene AVL9 cell migration associated

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3',5'-cyclic-GMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cAMP binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin-dependent cyclic-nucleotide phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
Names
3',5'-cyclic-AMP phosphodiesterase
3',5'-cyclic-GMP phosphodiesterase
cam-PDE 1C
NP_001020739.1
NP_001153424.1
NP_001153425.1
NP_001153427.1
NP_001153428.1
NP_001153429.1
NP_001153432.1
NP_001342404.1
NP_035184.1
XP_006505793.1
XP_006505796.1
XP_006505797.1
XP_006505798.3
XP_017176943.1
XP_030111081.1
XP_036021819.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025568.2NP_001020739.1  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform b

    See identical proteins and their annotated locations for NP_001020739.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. Variants 2 and 8 encode the same isoform (b).
    Source sequence(s)
    AC079956, AI853074, AK030423, BC032277
    Consensus CDS
    CCDS51785.1
    UniProtKB/Swiss-Prot
    Q64338
    UniProtKB/TrEMBL
    Q5D0E7
    Related
    ENSMUSP00000131350.2, ENSMUST00000166102.8
    Conserved Domains (3) summary
    PTZ00121
    Location:543628
    PTZ00121; MAEBL; Provisional
    pfam00233
    Location:227455
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:86142
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
  2. NM_001159952.1NP_001153424.1  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region, compared to variant 2. This results in a shorter protein (isoform c), compared to isoform b.
    Source sequence(s)
    AC079956, AI853074, AK030423, AK082180, AK139923, BC032277
    Consensus CDS
    CCDS51783.1
    UniProtKB/Swiss-Prot
    Q64338
    UniProtKB/TrEMBL
    E9Q7V6, Q3USZ6, Q5D0E7
    Related
    ENSMUSP00000130139.2, ENSMUST00000164037.3
    Conserved Domains (2) summary
    pfam00233
    Location:218446
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:77133
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
  3. NM_001159953.1NP_001153425.1  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform d

    See identical proteins and their annotated locations for NP_001153425.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate exon structure in the 3' coding region compared to variant 2. It encodes isoform d, which is longer and has a distinct C-terminus, compared to isoform b.
    Source sequence(s)
    AK030423, AK082497, AK133243
    Consensus CDS
    CCDS51784.1
    UniProtKB/Swiss-Prot
    Q64338
    Related
    ENSMUSP00000046601.8, ENSMUST00000044505.14
    Conserved Domains (2) summary
    pfam00233
    Location:227455
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:86142
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
  4. NM_001159955.1NP_001153427.1  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform a

    See identical proteins and their annotated locations for NP_001153427.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate 3' exon structure compared to variant 2. Variants 1, 7 and 9 encode the same isoform (a), which is longer and has a distinct C-terminus, compared to isoform b.
    Source sequence(s)
    AC079365, AK015375, AK077123, AK082497, BB614593
    Consensus CDS
    CCDS20170.1
    UniProtKB/Swiss-Prot
    Q64338
    UniProtKB/TrEMBL
    Q9D5W0
    Related
    ENSMUSP00000128364.2, ENSMUST00000168944.8
    Conserved Domains (3) summary
    pfam00233
    Location:227445
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:86142
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
    cl26511
    Location:543633
    Neuromodulin_N; Gap junction protein N-terminal region
  5. NM_001159956.1NP_001153428.1  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform f

    See identical proteins and their annotated locations for NP_001153428.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, 5' coding region, and 3' coding region, compared to variant 2. This results in distinct N- and C-termini and a shorter protein (isoform f), compared to isoform b.
    Source sequence(s)
    AC079365, AK014887, AK082497, BB614593
    Consensus CDS
    CCDS51786.1
    UniProtKB/TrEMBL
    Q9D5W0
    Related
    ENSMUSP00000133170.2, ENSMUST00000170774.8
    Conserved Domains (2) summary
    pfam00233
    Location:190418
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:49105
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
  6. NM_001159957.1NP_001153429.1  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform e

    See identical proteins and their annotated locations for NP_001153429.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region but maintains the reading frame, compared to variant 2. This results in a distinct N-terminus and shorter protein (isoform e), compared to isoform b.
    Source sequence(s)
    AC079956, AI853074, AK029531, BB614593, BC032277
    Consensus CDS
    CCDS51787.1
    UniProtKB/TrEMBL
    Q5D0E7, Q8CDV2
    Related
    ENSMUSP00000131892.2, ENSMUST00000166890.8
    Conserved Domains (2) summary
    pfam00233
    Location:199427
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:58114
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
  7. NM_001159960.1NP_001153432.1  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform b

    See identical proteins and their annotated locations for NP_001153432.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, compared to variant 2. Variants 2 and 8 encode the same isoform (b).
    Source sequence(s)
    AC079956, AI853074, AK029531, AK050499, BB654130, BC032277
    Consensus CDS
    CCDS51785.1
    UniProtKB/Swiss-Prot
    Q64338
    UniProtKB/TrEMBL
    Q5D0E7, Q8CDV2
    Related
    ENSMUSP00000129185.2, ENSMUST00000164752.8
    Conserved Domains (3) summary
    PTZ00121
    Location:543628
    PTZ00121; MAEBL; Provisional
    pfam00233
    Location:227455
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:86142
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
  8. NM_001355475.1NP_001342404.1  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) uses an alternate 3' exon structure compared to variant 2. Variants 1, 7 and 9 encode the same isoform (a), which is longer and has a distinct C-terminus, compared to isoform b.
    Source sequence(s)
    AC079274, AC079365, AC079956
    Consensus CDS
    CCDS20170.1
    Conserved Domains (3) summary
    pfam00233
    Location:227445
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:86142
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
    cl26511
    Location:543633
    Neuromodulin_N; Gap junction protein N-terminal region
  9. NM_011054.4NP_035184.1  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform a

    See identical proteins and their annotated locations for NP_035184.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and uses an alternate 3' exon structure compared to variant 2. Variants 1, 7 and 9 encode the same isoform (a), which is longer and has a distinct C-terminus, compared to isoform b.
    Source sequence(s)
    AC044804, AC079274, AC079365, AK082497
    Consensus CDS
    CCDS20170.1
    UniProtKB/Swiss-Prot
    Q64338
    Related
    ENSMUSP00000109966.3, ENSMUST00000114327.9
    Conserved Domains (3) summary
    pfam00233
    Location:227445
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:86142
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
    cl26511
    Location:543633
    Neuromodulin_N; Gap junction protein N-terminal region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    56046783..56629494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505730.5XP_006505793.1  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1

    Related
    ENSMUSP00000158960.2, ENSMUST00000239143.2
    Conserved Domains (3) summary
    PTZ00121
    Location:698788
    PTZ00121; MAEBL; Provisional
    pfam00233
    Location:382610
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:241297
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
  2. XM_006505734.2XP_006505797.1  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X3

    UniProtKB/TrEMBL
    A0A0N4SWG4
    Related
    ENSMUSP00000145508.2, ENSMUST00000203372.3
    Conserved Domains (3) summary
    PTZ00121
    Location:603693
    PTZ00121; MAEBL; Provisional
    pfam00233
    Location:287515
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:146202
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
  3. XM_006505735.3XP_006505798.3  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X4

    Conserved Domains (3) summary
    PTZ00121
    Location:537627
    PTZ00121; MAEBL; Provisional
    pfam00233
    Location:221449
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:80136
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
  4. XM_030255221.1XP_030111081.1  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X6

    Conserved Domains (3) summary
    PTZ00121
    Location:543628
    PTZ00121; MAEBL; Provisional
    pfam00233
    Location:227455
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:86142
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
  5. XM_017321454.2XP_017176943.1  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X6

    UniProtKB/Swiss-Prot
    Q64338
    UniProtKB/TrEMBL
    Q5D0E7
    Conserved Domains (3) summary
    PTZ00121
    Location:543628
    PTZ00121; MAEBL; Provisional
    pfam00233
    Location:227455
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:86142
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
  6. XM_006505733.4XP_006505796.1  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X2

    Conserved Domains (4) summary
    PTZ00121
    Location:698783
    PTZ00121; MAEBL; Provisional
    pfam00233
    Location:382610
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:241297
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
    pfam15242
    Location:299
    FAM53; Family of FAM53
  7. XM_036165926.1XP_036021819.1  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X5

    Conserved Domains (3) summary
    PTZ00121
    Location:603688
    PTZ00121; MAEBL; Provisional
    pfam00233
    Location:287515
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:146202
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

RNA

  1. XR_003956167.1 RNA Sequence

  2. XR_003956169.1 RNA Sequence

  3. XR_003956168.1 RNA Sequence

  4. XR_004942922.1 RNA Sequence

  5. XR_003956172.1 RNA Sequence

  6. XR_003956171.2 RNA Sequence

  7. XR_003956170.2 RNA Sequence

  8. XR_004942923.1 RNA Sequence

  9. XR_377431.2 RNA Sequence

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