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Abcb1b ATP-binding cassette, sub-family B (MDR/TAP), member 1B [ Mus musculus (house mouse) ]

Gene ID: 18669, updated on 22-May-2022

Summary

Official Symbol
Abcb1bprovided by MGI
Official Full Name
ATP-binding cassette, sub-family B (MDR/TAP), member 1Bprovided by MGI
Primary source
MGI:MGI:97568
See related
Ensembl:ENSMUSG00000028970 AllianceGenome:MGI:97568
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mdr; Mdr1; Pgy1; Abcb1; Mdr1b; Pgy-1
Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene encodes a membrane glycoprotein which confers a multidrug-resistance phenotype. The protein encoded by the human gene is an ATP-dependent drug efflux pump for xenobiotic compounds which is responsible for decreased drug accumulation in multidrug-resistant cells and mediates the development of resistance to anticancer drugs. [provided by RefSeq, Jul 2008]
Expression
Biased expression in adrenal adult (RPKM 39.4), placenta adult (RPKM 7.7) and 4 other tissues See more
Orthologs
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Genomic context

See Abcb1b in Genome Data Viewer
Location:
5 A1; 5 3.43 cM
Exon count:
30
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (8848147..8916314)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (8798147..8866314)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (8798147..8866314)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RUN domain containing 3B Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 1A Neighboring gene predicted gene, 31157 Neighboring gene predicted gene 5106 Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 4 Neighboring gene calponin 3, acidic pseudogene Neighboring gene predicted gene, 31388

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type xenobiotic transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled intramembrane lipid transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATPase-coupled transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables carboxylic acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables ceramide floppase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ceramide floppase activity ISO
Inferred from Sequence Orthology
more info
 
enables efflux transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables floppase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylcholine floppase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylcholine floppase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylethanolamine flippase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylethanolamine flippase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables xenobiotic transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables xenobiotic transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in Sertoli cell barrier remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in carboxylic acid transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in ceramide translocation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ceramide translocation ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of endothelial blood-brain barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phospholipid translocation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of anion channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of chloride transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of response to osmotic stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in transepithelial transport ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in xenobiotic transport across blood-brain barrier ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in external side of apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intercellular canaliculus IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ATP-dependent translocase ABCB1
Names
ATP-binding cassette sub-family B member 1
P glycoprotein 1
multidrug resistance protein 1
multidrug resistance protein 1B
phospholipid transporter ABCB1
NP_035205.1
XP_030110060.1
XP_036020766.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011075.2NP_035205.1  ATP-dependent translocase ABCB1

    See identical proteins and their annotated locations for NP_035205.1

    Status: VALIDATED

    Source sequence(s)
    AK030328, AK139854, BG080311, BQ829721, BY435708, DV651684
    Consensus CDS
    CCDS19085.1
    UniProtKB/Swiss-Prot
    P06795
    UniProtKB/TrEMBL
    B2RUR3
    Related
    ENSMUSP00000009058.6, ENSMUST00000009058.10
    Conserved Domains (1) summary
    PTZ00265
    Location:551270
    PTZ00265; multidrug resistance protein (mdr1); Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    8848147..8916314
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254200.2XP_030110060.1  ATP-dependent translocase ABCB1 isoform X1

    Conserved Domains (1) summary
    PTZ00265
    Location:4883
    PTZ00265; multidrug resistance protein (mdr1); Provisional
  2. XM_036164873.1XP_036020766.1  ATP-dependent translocase ABCB1 isoform X2

    Conserved Domains (2) summary
    cd03249
    Location:245484
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    COG1132
    Location:2483
    MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]