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Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A [ Mus musculus (house mouse) ]

Gene ID: 18671, updated on 22-May-2022

Summary

Official Symbol
Abcb1aprovided by MGI
Official Full Name
ATP-binding cassette, sub-family B (MDR/TAP), member 1Aprovided by MGI
Primary source
MGI:MGI:97570
See related
Ensembl:ENSMUSG00000040584 AllianceGenome:MGI:97570
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pgp; Mdr3; P-gp; Pgy3; Abcb4; Evi32; Mdr1a; Pgy-3; mdr-3
Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a p-glycoprotein which actively transports a variety of hydrophobic amphipathic drugs and plays a major role in the blood-brain barrier permeability of certain drugs. [provided by RefSeq, Jul 2008]
Expression
Broad expression in colon adult (RPKM 25.6), large intestine adult (RPKM 9.1) and 15 other tissues See more
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Genomic context

See Abcb1a in Genome Data Viewer
Location:
5 A1; 5 3.43 cM
Exon count:
30
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (8617091..8798575)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (8567091..8748575)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (8660092..8748570)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene a disintegrin and metallopeptidase domain 22 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene solute carrier family 25, member 40 Neighboring gene DBF4 zinc finger Neighboring gene RUN domain containing 3B Neighboring gene predicted gene, 31157 Neighboring gene predicted gene 5106 Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 1B Neighboring gene calponin 3, acidic pseudogene Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the Abcb1a gene: The Abcb1a gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, fruit fly, C.elegans, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type xenobiotic transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATPase-coupled intramembrane lipid transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled transmembrane transporter activity EXP
Inferred from Experiment
more info
PubMed 
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATPase-coupled transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables carboxylic acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables ceramide floppase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ceramide floppase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ceramide floppase activity ISO
Inferred from Sequence Orthology
more info
 
enables efflux transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables efflux transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables floppase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables floppase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylcholine floppase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylcholine floppase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylcholine floppase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylethanolamine flippase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylethanolamine flippase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylethanolamine flippase activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables xenobiotic transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables xenobiotic transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables xenobiotic transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in carboxylic acid transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in ceramide translocation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ceramide translocation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ceramide translocation ISO
Inferred from Sequence Orthology
more info
 
involved_in daunorubicin transport ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of blood-brain barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of blood-retinal barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in export across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in hormone transport ISO
Inferred from Sequence Orthology
more info
 
involved_in intestinal absorption ISO
Inferred from Sequence Orthology
more info
 
involved_in maintenance of blood-brain barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phospholipid translocation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phospholipid translocation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of anion channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of establishment of Sertoli cell barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of response to drug ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of chloride transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of intestinal absorption ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of response to osmotic stress ISO
Inferred from Sequence Orthology
more info
 
involved_in stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in terpenoid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transepithelial transport ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within xenobiotic detoxification by transmembrane export across the plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in xenobiotic transport across blood-brain barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in xenobiotic transport across blood-brain barrier ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intercellular canaliculus IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ATP-dependent translocase ABCB1
Names
ATP-binding cassette sub-family B member 1A
ATP-binding cassette, sub-family B (MDR/TAP), member 4
ATP-binding cassette, subfamily B, member 1A
P-glycoprotein 3
ecotropic viral integration site 32
multi-drug resistance 3
multidrug resistance protein 3
multiple drug resistant 1a
phospholipid transporter ABCB1
NP_035206.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011076.3NP_035206.2  ATP-dependent translocase ABCB1

    See identical proteins and their annotated locations for NP_035206.2

    Status: VALIDATED

    Source sequence(s)
    AC107733, AC121955, AC140398
    Consensus CDS
    CCDS19084.1
    UniProtKB/Swiss-Prot
    P21447
    UniProtKB/TrEMBL
    Q9CVG4
    Related
    ENSMUSP00000041204.5, ENSMUST00000047753.5
    Conserved Domains (1) summary
    PTZ00265
    Location:471263
    PTZ00265; multidrug resistance protein (mdr1); Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    8617091..8798575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)