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Prkcb protein kinase C, beta [ Mus musculus (house mouse) ]

Gene ID: 18751, updated on 17-Oct-2021

Summary

Official Symbol
Prkcbprovided by MGI
Official Full Name
protein kinase C, betaprovided by MGI
Primary source
MGI:MGI:97596
See related
Ensembl:ENSMUSG00000052889
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pkcb; PKC-B; Prkcb1; Prkcb2; PKC-Beta
Expression
Biased expression in cortex adult (RPKM 62.0), frontal lobe adult (RPKM 44.4) and 8 other tissues See more
Orthologs
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Genomic context

See Prkcb in Genome Data Viewer
Location:
7 F2; 7 65.75 cM
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (121888327..122233625)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (122289104..122634402)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (129432639..129777916)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23614 Neighboring gene predicted gene, 30059 Neighboring gene predicted gene, 51497 Neighboring gene acid phosphatase 1 pseudogene Neighboring gene calcium channel, voltage-dependent, gamma subunit 3 Neighboring gene predicted gene, 29759

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Chemically induced (ENU) (7) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables androgen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium channel regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent protein kinase C activity IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
enables histone kinase activity (H3-T6 specific) ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase C activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase C activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in B cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular calcium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to carbohydrate stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in histone H3-T6 phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of glucose transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of dopamine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of glucose transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of growth ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
NOT acts_upstream_of_or_within response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
 
located_in calyx of Held IDA
Inferred from Direct Assay
more info
PubMed 
located_in calyx of Held IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic cytosol IDA
Inferred from Direct Assay
more info
PubMed 
part_of spectrin IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein kinase C beta type
Names
protein kinase C beta-II
protein kinase C, beta 1
NP_001303601.1
NP_032881.1
XP_030098077.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316672.1NP_001303601.1  protein kinase C beta type isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3'-terminal exon compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK051862, BU701138, BY729820, CJ050078
    Consensus CDS
    CCDS85402.1
    UniProtKB/Swiss-Prot
    P68404
    Related
    ENSMUSP00000064812.5, ENSMUST00000064921.5
    Conserved Domains (4) summary
    cd04026
    Location:159289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05616
    Location:341664
    STKc_cPKC_beta; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta
    cd20833
    Location:3592
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:102155
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
  2. NM_008855.2NP_032881.1  protein kinase C beta type isoform 1

    See identical proteins and their annotated locations for NP_032881.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC016522, AK051862, BY729820, CJ050078
    Consensus CDS
    CCDS21815.1
    UniProtKB/Swiss-Prot
    P68404
    Related
    ENSMUSP00000070019.6, ENSMUST00000064989.12
    Conserved Domains (4) summary
    cd04026
    Location:159289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05616
    Location:341663
    STKc_cPKC_beta; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta
    cd20833
    Location:3592
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:102155
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    121888327..122233625
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242217.1XP_030098077.1  protein kinase C beta type isoform X1

    Conserved Domains (2) summary
    cd04026
    Location:30160
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05616
    Location:212534
    STKc_cPKC_beta; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta
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