Plaa phospholipase A2, activating protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plaaprovided by MGI
Official Full Name: phospholipase A2, activating proteinprovided by MGI
Primary source: MGI:MGI:104810
See related: Ensembl:ENSMUSG00000028577 AllianceGenome:MGI:104810
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PLAP; Ufd3; PLA2P; 2410007N06; D4Ertd618e
Summary: Enables phospholipase A2 activator activity. Involved in several processes, including negative regulation of protein K63-linked ubiquitination; positive regulation of dendrite extension; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Acts upstream of or within inflammatory response. Located in cytoplasm; nucleus; and synapse. Orthologous to human PLAA (phospholipase A2 activating protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 9.7), placenta adult (RPKM 8.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C5; 4 43.34 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (94453371..94491410, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (94565139..94603247, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We demonstrate that PLAA is essential for neural function, through dual roles of (1) regulating post-endocytic trafficking of signaling receptors necessary for neural development and (2) directing sorting of synaptic vesicle (SV) components during recycling, essential for synaptic function.
Title: PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins.
miR-203 may regulate expression of the novel nociceptive mediator PLAA after incision.
Title: miR-203 regulates nociceptive sensitization after incision by controlling phospholipase A2 activating protein expression.
Phospholipase A2 activating protein is required for 1alpha,25-dihydroxyvitamin D3 dependent rapid activation of protein kinase C via Pdia3
Title: Phospholipase A2 activating protein is required for 1α,25-dihydroxyvitamin D3 dependent rapid activation of protein kinase C via Pdia3.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136469 (e-PCR)
- UniSTS:210454

AW208417 (e-PCR)
- UniSTS:179030

Plaa (e-PCR), detects polymorphism
- UniSTS:546950

AI536418 (e-PCR)
- UniSTS:165337

D4Ertd618e (e-PCR), detects polymorphism
- UniSTS:167404

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phospholipase A2 activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in macroautophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein K63-linked ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendrite extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic vesicle recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in prostaglandin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phospholipase A-2-activating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001424835.1 → NP_001411764.1 phospholipase A-2-activating protein isoform 2

Status: VALIDATED

Source sequence(s)

AL732597
NM_001424836.1 → NP_001411765.1 phospholipase A-2-activating protein isoform 3

Status: VALIDATED

Source sequence(s)

AL732597
NM_001424837.1 → NP_001411766.1 phospholipase A-2-activating protein isoform 4

Status: VALIDATED

Source sequence(s)

AL732597
NM_001424838.1 → NP_001411767.1 phospholipase A-2-activating protein isoform 5

Status: VALIDATED

Source sequence(s)

AL732597
NM_001424839.1 → NP_001411768.1 phospholipase A-2-activating protein isoform 6

Status: VALIDATED

Source sequence(s)

AL732597
NM_172695.3 → NP_766283.2 phospholipase A-2-activating protein isoform 1

See identical proteins and their annotated locations for NP_766283.2

Status: VALIDATED

Source sequence(s)

AL732597

Consensus CDS

CCDS18359.1

UniProtKB/Swiss-Prot

A4QPD6, P27612, Q8C6C4

Related

ENSMUSP00000102724.3, ENSMUST00000107107.9

Conserved Domains (5) summary

COG2319
Location:6 → 296

WD40; WD40 repeat [General function prediction only]

cd00200
Location:10 → 297

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08324
Location:536 → 788

PUL; PUL domain

pfam09070
Location:346 → 459

PFU; PFU (PLAA family ubiquitin binding)

sd00039
Location:69 → 110

7WD40; WD40 repeat [structural motif]