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Serpinb2 serine (or cysteine) peptidase inhibitor, clade B, member 2 [ Mus musculus (house mouse) ]

Gene ID: 18788, updated on 21-Aug-2019

Summary

Official Symbol
Serpinb2provided by MGI
Official Full Name
serine (or cysteine) peptidase inhibitor, clade B, member 2provided by MGI
Primary source
MGI:MGI:97609
See related
Ensembl:ENSMUSG00000062345
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAI-2; Planh2; ovalbumin
Expression
Biased expression in liver E14 (RPKM 1.2), liver E14.5 (RPKM 1.0) and 14 other tissues See more
Orthologs

Genomic context

See Serpinb2 in Genome Data Viewer
Location:
1 E2.1; 1 50.34 cM
Exon count:
10
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (107500892..107525600)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (109408000..109422177)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 11 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 7 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10 Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 8

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • Blood Clotting Cascade, organism-specific biosystem (from WikiPathways)
    Blood Clotting Cascade, organism-specific biosystemCoagulation is a complex process by which blood forms clots. It is an important part of hemostasis (the cessation of blood loss from a damaged vessel), wherein a damaged blood vessel wall is covered ...
  • Complement and coagulation cascades, organism-specific biosystem (from KEGG)
    Complement and coagulation cascades, organism-specific biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
  • Complement and coagulation cascades, conserved biosystem (from KEGG)
    Complement and coagulation cascades, conserved biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
  • Dissolution of Fibrin Clot, organism-specific biosystem (from REACTOME)
    Dissolution of Fibrin Clot, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
plasminogen activator inhibitor 2, macrophage
Names
plasminogen activator inhibitor, type II
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2
serine (or cysteine) proteinase inhibitor, clade B, member 2
serpin B2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001174170.1NP_001167641.1  plasminogen activator inhibitor 2, macrophage

    See identical proteins and their annotated locations for NP_001167641.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AI847983, AK081487
    Consensus CDS
    CCDS15219.1
    UniProtKB/Swiss-Prot
    P12388
    UniProtKB/TrEMBL
    Q542A3
    Related
    ENSMUSP00000009356.4, ENSMUST00000009356.10
    Conserved Domains (1) summary
    cl00137
    Location:4415
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
  2. NM_011111.4NP_035241.1  plasminogen activator inhibitor 2, macrophage

    See identical proteins and their annotated locations for NP_035241.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AI847983, AK090049, BY195599
    Consensus CDS
    CCDS15219.1
    UniProtKB/Swiss-Prot
    P12388
    UniProtKB/TrEMBL
    Q542A3
    Related
    ENSMUSP00000065277.2, ENSMUST00000064916.8
    Conserved Domains (1) summary
    cl00137
    Location:4415
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p6 C57BL/6J

    Range
    107500892..107525600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247942.1XP_011246244.1  plasminogen activator inhibitor 2, macrophage isoform X1

    Conserved Domains (1) summary
    cl00137
    Location:19430
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
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