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Plec plectin [ Mus musculus (house mouse) ]

Gene ID: 18810, updated on 7-Nov-2021

Summary

Official Symbol
Plecprovided by MGI
Official Full Name
plectinprovided by MGI
Primary source
MGI:MGI:1277961
See related
Ensembl:ENSMUSG00000022565
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PCN; EBS1; PLTN; Plec1; AA591047; AU042537
Summary
Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, 17499243). Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010, this locus was named plectin 1 (symbol PLEC1 in human; Plec1 in mouse and rat) and the gene product had been referred to as "hemidesmosomal protein 1" or "plectin 1, intermediate filament binding 500kDa". These names were superseded by plectin. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail (PMID: 10556294, 14559777), revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms. Eleven exons (1-1j) have been identified that alternatively splice directly into a common exon 2 which is the first exon to encode plectin's highly conserved actin binding domain (ABD). Three additional exons (-1, 0a, and 0) splice into an alternative first coding exon (1c), and two additional exons (2alpha and 3alpha) are optionally spliced within the exons encoding the acting binding domain (exons 2-8). Analysis of the human locus has identified eight of the eleven alternative 5' exons found in mouse and rat (PMID: 14672974); exons 1i, 1j and 1h have not been confirmed in human. Furthermore, isoforms lacking the central rod domain encoded by exon 31 have been detected in mouse (PMID:10556294), rat (PMID: 9177781), and human (PMID: 11441066, 10780662, 20052759). It has been shown that the short alternative amino-terminal sequences encoded by the different first exons direct the targeting of the various isoforms to distinct subcellular locations (PMID: 14559777). As the expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development (PMID: 10556294, 12542521, 17389230) it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms, as if custom-made for specific requirements of the particular cells. Concordantly, individual isoforms were found to carry out distinct and specific functions (PMID: 14559777, 12542521, 18541706). In 1996, a number of groups reported that patients suffering from epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) lacked plectin expression in skin and muscle tissues due to defects in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687, 8696340). Two other subtypes of plectin-related EBS have been described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of plectin-related diseases see PMID: 15810881, 19945614. Mutations in the plectin gene related to human diseases should be named based on the position in NM_000445 (human variant 1, isoform 1c), unless the mutation is located within one of the other alternative first exons, in which case the position in the respective Reference Sequence should be used. [provided by RefSeq, Aug 2011]
Expression
Broad expression in small intestine adult (RPKM 67.8), colon adult (RPKM 65.2) and 22 other tissues See more
Orthologs
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Genomic context

See Plec in Genome Data Viewer
Location:
15 D3; 15 35.48 cM
Exon count:
44
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76055174..76115578, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76170974..76231378, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (76001404..76061808, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35087 Neighboring gene cyclin-dependent kinases regulatory subunit 2 pseudogene Neighboring gene microRNA 1942 Neighboring gene poly (ADP-ribose) polymerase family, member 10 Neighboring gene microRNA 6953 Neighboring gene glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables actin filament binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ankyrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ankyrin binding ISO
Inferred from Sequence Orthology
more info
 
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
enables dystroglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein self-association IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables structural constituent of cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of muscle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables structural constituent of muscle ISO
Inferred from Sequence Orthology
more info
 
enables structural molecule activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actin cytoskeleton reorganization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actomyosin contractile ring assembly actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adherens junction organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to extracellular stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to fluid shear stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to hydrostatic pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of skin barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fibroblast migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hemidesmosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in hemidesmosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in intermediate filament cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intermediate filament cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intermediate filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in keratinocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leukocyte migration involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrion morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myelination in peripheral nervous system IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleus organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peripheral nervous system myelin maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein-containing complex subunit organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of ATP citrate synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of vascular permeability IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in respiratory electron transport chain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to food IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to nutrient ISO
Inferred from Sequence Orthology
more info
 
involved_in sarcomere organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in skeletal muscle fiber development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in skeletal myofibril assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in skin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tight junction organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmission of nerve impulse IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in wound healing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Z disc IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in brush border IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in contractile fiber IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
is_active_in hemidesmosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in hemidesmosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in hemidesmosome ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with intermediate filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in mitochondrial outer membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
located_in myofibril IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 
located_in sarcoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
plectin
Names
plectin-1
plectin-6

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163540.1NP_001157012.1  plectin isoform 12alpha

    See identical proteins and their annotated locations for NP_001157012.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), also known as 12alpha, differs in the 5' UTR and the 5' coding region, and contains an additional in-frame coding exon compared to variant 1. The resulting protein (isoform 12alpha) contains a distinct N-terminus and contains a 5 aa internal protein segment compared to isoform 1c. This variant (13) contains the same 5' coding exon as variant 6 but also contains an alternate in-frame exon so the resulting protein contains a 5aa internal segment compared to isoform 1.
    Source sequence(s)
    AF188008, AI464512, AY480033, CN669707
    Consensus CDS
    CCDS49647.1
    UniProtKB/Swiss-Prot
    Q9QXS1
    Related
    ENSMUSP00000073124.7, ENSMUST00000073418.13
    Conserved Domains (12) summary
    smart00150
    Location:667761
    SPEC; Spectrin repeats
    smart00250
    Location:32383274
    PLEC; Plectin repeat
    cd00014
    Location:186293
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:763941
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:308406
    CH; Calponin homology (CH) domain
    pfam00681
    Location:29482989
    Plectin; Plectin repeat
    pfam01576
    Location:15262713
    Myosin_tail_1; Myosin tail
    pfam03501
    Location:7101
    S10_plectin; Plectin/S10 domain
    cd16269
    Location:24772490
    GBP_C; coiled coil [structural motif]
    cl02488
    Location:18712046
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl20817
    Location:23262510
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21478
    Location:16201743
    ATP-synt_B; ATP synthase B/B' CF(0)
  2. NM_001163542.1NP_001157014.1  plectin isoform 1c2alpha3alpha

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), also known as 1c2alpha3alpha, contains two alternate in-frame exons compared to variant 1. This results in a protein (isoform 1c2alpha3alpha) with two internal protein segments (5 and 12 aa, respectively) compared to isoform 1c.
    Source sequence(s)
    AF188013, AI464512, AY480033, CN669707
    Consensus CDS
    CCDS49649.1
    UniProtKB/Swiss-Prot
    Q9QXS1
    Related
    ENSMUSP00000087037.4, ENSMUST00000089610.10
    Conserved Domains (10) summary
    smart00150
    Location:565659
    SPEC; Spectrin repeats
    smart00250
    Location:31363172
    PLEC; Plectin repeat
    cd00014
    Location:72191
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:661839
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:206304
    CH; Calponin homology (CH) domain
    pfam00681
    Location:28462887
    Plectin; Plectin repeat
    pfam01576
    Location:14242611
    Myosin_tail_1; Myosin tail
    cd16269
    Location:23752388
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:22242408
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21478
    Location:15181641
    ATP-synt_B; ATP synthase B/B' CF(0)
  3. NM_001163549.1NP_001157021.1  plectin isoform 1b2alpha

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), also known as 1b2alpha, differs in the 5' UTR and the 5' coding region, and contains an additional in-frame coding exon compared to variant 1. The resulting protein (isoform 1b2alpha) contains a distinct N-terminus and contains a 5 aa internal protein segment compared to isoform 1c. This variant (14) contains the same 5' coding exon as variant 8 but also contains an alternate in-frame exon so the resulting protein contains a 5aa internal segment compared to isoform 1b.
    Source sequence(s)
    AF188011, AI464512, AY480033, CN669707
    Consensus CDS
    CCDS49645.1
    UniProtKB/Swiss-Prot
    Q9QXS1
    Related
    ENSMUSP00000057158.8, ENSMUST00000054449.14
    Conserved Domains (10) summary
    smart00150
    Location:524618
    SPEC; Spectrin repeats
    smart00250
    Location:30953131
    PLEC; Plectin repeat
    cd00014
    Location:43150
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:620798
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:165263
    CH; Calponin homology (CH) domain
    pfam00681
    Location:28052846
    Plectin; Plectin repeat
    pfam01576
    Location:13832570
    Myosin_tail_1; Myosin tail
    cd16269
    Location:23342347
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:21832367
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21478
    Location:14771600
    ATP-synt_B; ATP synthase B/B' CF(0)
  4. NM_001164203.1NP_001157675.1  plectin isoform 1hij

    See identical proteins and their annotated locations for NP_001157675.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), also known as 1j2alpha3alpha, contains an alternate 5' terminal exon and additional exons which result in a distinct 5' UTR and cause translation initiation at a downstream start codon compared to variant 1. The resulting protein (isoform 1hij) has a shorter N-terminus compared to isoform 1c. Variants 4, 5, 9 and 12 encode the same protein. Support for the use of the alternate downstream start codon can be found in PMID:14559777.
    Source sequence(s)
    AC110211, AF188023, AY480037
    Consensus CDS
    CCDS37117.2
    UniProtKB/Swiss-Prot
    Q9QXS1
    UniProtKB/TrEMBL
    E9Q3W4, Q6S390
    Related
    ENSMUSP00000079668.6, ENSMUST00000080857.12
    Conserved Domains (9) summary
    smart00150
    Location:362456
    SPEC; Spectrin repeats
    smart00250
    Location:29332969
    PLEC; Plectin repeat
    cd00176
    Location:458636
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:3101
    CH; Calponin homology (CH) domain
    pfam00681
    Location:26432684
    Plectin; Plectin repeat
    pfam01576
    Location:12212408
    Myosin_tail_1; Myosin tail
    cd16269
    Location:21722185
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:20882205
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21478
    Location:13151438
    ATP-synt_B; ATP synthase B/B' CF(0)
  5. NM_011117.2NP_035247.2  plectin isoform 1c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) contains the 5'-most coding exon (exon 1c) and encodes isoform 1c.
    Source sequence(s)
    AI464512, AY480033, CN669707
    UniProtKB/Swiss-Prot
    Q9QXS1
    Conserved Domains (10) summary
    smart00150
    Location:548642
    SPEC; Spectrin repeats
    smart00250
    Location:31193155
    PLEC; Plectin repeat
    cd00014
    Location:72174
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:644822
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:189287
    CH; Calponin homology (CH) domain
    pfam00681
    Location:28292870
    Plectin; Plectin repeat
    pfam01576
    Location:14072594
    Myosin_tail_1; Myosin tail
    cd16269
    Location:23582371
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:22072391
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21478
    Location:15011624
    ATP-synt_B; ATP synthase B/B' CF(0)
  6. NM_201385.2NP_958787.2  plectin isoform 1f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as 1f, differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1f) contains a distinct N-terminus compared to isoform 1c.
    Source sequence(s)
    AI464512, AY480034, CN669707
    Consensus CDS
    CCDS37113.1
    UniProtKB/TrEMBL
    Q6S393
    Related
    ENSMUSP00000074383.6, ENSMUST00000074834.12
    Conserved Domains (10) summary
    smart00150
    Location:510604
    SPEC; Spectrin repeats
    smart00250
    Location:30813117
    PLEC; Plectin repeat
    cd00014
    Location:34136
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:606784
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:151249
    CH; Calponin homology (CH) domain
    pfam00681
    Location:27912832
    Plectin; Plectin repeat
    pfam01576
    Location:13692556
    Myosin_tail_1; Myosin tail
    cd16269
    Location:23202333
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:21692353
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21478
    Location:14631586
    ATP-synt_B; ATP synthase B/B' CF(0)
  7. NM_201386.2NP_958788.2  plectin isoform 1e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as 1e, differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1e) contains a distinct N-terminus compared to isoform 1c.
    Source sequence(s)
    AC110211, AY480035
    Consensus CDS
    CCDS49648.1
    UniProtKB/TrEMBL
    Q6S392
    Related
    ENSMUSP00000071765.6, ENSMUST00000071869.12
    Conserved Domains (10) summary
    smart00150
    Location:497591
    SPEC; Spectrin repeats
    smart00250
    Location:30683104
    PLEC; Plectin repeat
    cd00014
    Location:21123
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:593771
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:138236
    CH; Calponin homology (CH) domain
    pfam00681
    Location:27782819
    Plectin; Plectin repeat
    pfam01576
    Location:13562543
    Myosin_tail_1; Myosin tail
    cd16269
    Location:23072320
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:21562340
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21478
    Location:14501573
    ATP-synt_B; ATP synthase B/B' CF(0)
  8. NM_201387.3NP_958789.3  plectin isoform 1hij

    See identical proteins and their annotated locations for NP_958789.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as 1i, contains an alternate 5' terminal exon which results in a distinct 5' UTR and causes translation initiation at a downstream start codon compared to variant 1. The resulting protein (isoform 1hij) has a shorter N-terminus compared to isoform 1c. Variants 4, 5, 9 and 12 encode the same protein. Support for the use of the alternate downstream start codon can be found in PMID:14559777.
    Source sequence(s)
    AC110211, AY480036
    Consensus CDS
    CCDS37117.2
    UniProtKB/TrEMBL
    E9Q3W4, Q6S390
    Related
    ENSMUSP00000129543.2, ENSMUST00000171562.8
    Conserved Domains (9) summary
    smart00150
    Location:362456
    SPEC; Spectrin repeats
    smart00250
    Location:29332969
    PLEC; Plectin repeat
    cd00176
    Location:458636
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:3101
    CH; Calponin homology (CH) domain
    pfam00681
    Location:26432684
    Plectin; Plectin repeat
    pfam01576
    Location:12212408
    Myosin_tail_1; Myosin tail
    cd16269
    Location:21722185
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:20882205
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21478
    Location:13151438
    ATP-synt_B; ATP synthase B/B' CF(0)
  9. NM_201388.2NP_958790.2  plectin isoform 1hij

    See identical proteins and their annotated locations for NP_958790.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), also known as 1j, contains an alternate 5' terminal exon which results in a distinct 5' UTR and causes translation initiation at a downstream start codon compared to variant 1. The resulting protein (isoform 1hij) has a shorter N-terminus compared to isoform 1c. Variants 4, 5, 9 and 12 encode the same protein. Support for the use of the alternate downstream start codon can be found in PMID:14559777.
    Source sequence(s)
    AC110211, AY480037
    Consensus CDS
    CCDS37117.2
    UniProtKB/TrEMBL
    E9Q3W4, Q6S390
    Conserved Domains (9) summary
    smart00150
    Location:362456
    SPEC; Spectrin repeats
    smart00250
    Location:29332969
    PLEC; Plectin repeat
    cd00176
    Location:458636
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:3101
    CH; Calponin homology (CH) domain
    pfam00681
    Location:26432684
    Plectin; Plectin repeat
    pfam01576
    Location:12212408
    Myosin_tail_1; Myosin tail
    cd16269
    Location:21722185
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:20882205
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21478
    Location:13151438
    ATP-synt_B; ATP synthase B/B' CF(0)
  10. NM_201389.2NP_958791.2  plectin isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1) contains a distinct N-terminus compared to isoform 1c.
    Source sequence(s)
    AI464512, AY480038, CN669707
    Consensus CDS
    CCDS37114.1
    UniProtKB/Swiss-Prot
    Q9QXS1
    Related
    ENSMUSP00000075772.6, ENSMUST00000076442.12
    Conserved Domains (12) summary
    smart00150
    Location:662756
    SPEC; Spectrin repeats
    smart00250
    Location:32333269
    PLEC; Plectin repeat
    cd00014
    Location:186288
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:758936
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:303401
    CH; Calponin homology (CH) domain
    pfam00681
    Location:29432984
    Plectin; Plectin repeat
    pfam01576
    Location:15212708
    Myosin_tail_1; Myosin tail
    pfam03501
    Location:7101
    S10_plectin; Plectin/S10 domain
    cd16269
    Location:24722485
    GBP_C; coiled coil [structural motif]
    cl02488
    Location:18662041
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl20817
    Location:23212505
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21478
    Location:16151738
    ATP-synt_B; ATP synthase B/B' CF(0)
  11. NM_201390.2NP_958792.2  plectin isoform 1d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), also known as 1d, differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1d) contains a distinct N-terminus compared to isoform 1c.
    Source sequence(s)
    AI464512, AY480039, CN669707
    Consensus CDS
    CCDS49646.1
    UniProtKB/TrEMBL
    Q6S388
    Related
    ENSMUSP00000126068.2, ENSMUST00000169108.8
    Conserved Domains (10) summary
    smart00150
    Location:487581
    SPEC; Spectrin repeats
    smart00250
    Location:30583094
    PLEC; Plectin repeat
    cd00014
    Location:11113
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:583761
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:128226
    CH; Calponin homology (CH) domain
    pfam00681
    Location:27682809
    Plectin; Plectin repeat
    pfam01576
    Location:13462533
    Myosin_tail_1; Myosin tail
    cd16269
    Location:22972310
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:22132330
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21478
    Location:14401563
    ATP-synt_B; ATP synthase B/B' CF(0)
  12. NM_201391.2NP_958793.2  plectin isoform 1b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), also known as 1b, differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1b) contains a distinct N-terminus compared to isoform 1c. Plectin isoform 1b has been found to associate exclusively with mitochondria (PMID: 18541706, 14559777).
    Source sequence(s)
    AI464512, AY480040, CN669707
    Consensus CDS
    CCDS49644.1
    UniProtKB/TrEMBL
    Q6S387
    Related
    ENSMUSP00000126526.2, ENSMUST00000169714.8
    Conserved Domains (10) summary
    smart00150
    Location:519613
    SPEC; Spectrin repeats
    smart00250
    Location:30903126
    PLEC; Plectin repeat
    cd00014
    Location:43145
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:615793
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:160258
    CH; Calponin homology (CH) domain
    pfam00681
    Location:28002841
    Plectin; Plectin repeat
    pfam01576
    Location:13782565
    Myosin_tail_1; Myosin tail
    cd16269
    Location:23292342
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:21782362
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21478
    Location:14721595
    ATP-synt_B; ATP synthase B/B' CF(0)
  13. NM_201392.2NP_958794.2  plectin isoform 1hij

    See identical proteins and their annotated locations for NP_958794.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), also known as 1h, contains an alternate 5' terminal exon which results in a distinct 5' UTR and causes translation initiation at a downstream start codon compared to variant 1. The resulting protein (isoform 1hij) has a shorter N-terminus compared to isoform 1c. Variants 4, 5, 9 and 12 encode the same protein. Support for the use of the alternate downstream start codon can be found in PMID:14559777.
    Source sequence(s)
    AC110211, AY480041
    Consensus CDS
    CCDS37117.2
    UniProtKB/TrEMBL
    E9Q3W4, Q6S390
    Related
    ENSMUSP00000127261.2, ENSMUST00000169438.8
    Conserved Domains (9) summary
    smart00150
    Location:362456
    SPEC; Spectrin repeats
    smart00250
    Location:29332969
    PLEC; Plectin repeat
    cd00176
    Location:458636
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:3101
    CH; Calponin homology (CH) domain
    pfam00681
    Location:26432684
    Plectin; Plectin repeat
    pfam01576
    Location:12212408
    Myosin_tail_1; Myosin tail
    cd16269
    Location:21722185
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:20882205
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21478
    Location:13151438
    ATP-synt_B; ATP synthase B/B' CF(0)
  14. NM_201393.2NP_958795.2  plectin isoform 1g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), also known as 1g, differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1g) contains a distinct N-terminus compared to isoform 1c.
    Source sequence(s)
    AI464512, AY480042, CN669707
    Consensus CDS
    CCDS37115.1
    UniProtKB/TrEMBL
    Q6S385
    Related
    ENSMUSP00000072478.5, ENSMUST00000072692.11
    Conserved Domains (10) summary
    smart00150
    Location:526620
    SPEC; Spectrin repeats
    smart00250
    Location:30973133
    PLEC; Plectin repeat
    cd00014
    Location:50152
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:622800
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:167265
    CH; Calponin homology (CH) domain
    pfam00681
    Location:28072848
    Plectin; Plectin repeat
    pfam01576
    Location:13852572
    Myosin_tail_1; Myosin tail
    cd16269
    Location:23362349
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:21852369
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21478
    Location:14791602
    ATP-synt_B; ATP synthase B/B' CF(0)
  15. NM_201394.2NP_958796.2  plectin isoform 1a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), also known as 1a, differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1a) contains a distinct N-terminus compared to isoform 1c.
    Source sequence(s)
    AI464512, AY480043, CN669707
    Consensus CDS
    CCDS37116.1
    UniProtKB/Swiss-Prot
    Q9QXS1
    Related
    ENSMUSP00000023226.7, ENSMUST00000023226.13
    Conserved Domains (10) summary
    smart00150
    Location:519613
    SPEC; Spectrin repeats
    smart00250
    Location:30903126
    PLEC; Plectin repeat
    cd00014
    Location:43145
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:615793
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00307
    Location:160258
    CH; Calponin homology (CH) domain
    pfam00681
    Location:28002841
    Plectin; Plectin repeat
    pfam01576
    Location:13782565
    Myosin_tail_1; Myosin tail
    cd16269
    Location:23292342
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:21782362
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21478
    Location:14721595
    ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76055174..76115578 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_028117.1: Suppressed sequence

    Description
    NR_028117.1: This RefSeq was permanently suppressed because there is support for the transcript as protein coding.
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