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Pltp phospholipid transfer protein [ Mus musculus (house mouse) ]

Gene ID: 18830, updated on 5-Jan-2022

Summary

Official Symbol
Pltpprovided by MGI
Official Full Name
phospholipid transfer proteinprovided by MGI
Primary source
MGI:MGI:103151
See related
Ensembl:ENSMUSG00000017754
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bpife; OD107
Summary
Enables lipid transfer activity. Acts upstream of or within flagellated sperm motility and vitamin E biosynthetic process. Located in extracellular space. Is expressed in dental placode; humerus cartilage condensation; oral epithelium; and tooth epithelium. Used to study dry eye syndrome. Orthologous to human PLTP (phospholipid transfer protein). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in lung adult (RPKM 368.4), subcutaneous fat pad adult (RPKM 153.5) and 18 other tissues See more
Orthologs
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Genomic context

See Pltp in Genome Data Viewer
Location:
2 H3; 2 85.27 cM
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164681438..164699628, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164839518..164857708, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (164665018..164683208, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 25 Neighboring gene neuralized E3 ubiquitin protein ligase 2 Neighboring gene cathepsin A Neighboring gene RIKEN cDNA 4930445K14 gene Neighboring gene phosphorylated CTD interacting factor 1 Neighboring gene predicted gene, 46775

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ceramide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ceramide binding ISO
Inferred from Sequence Orthology
more info
 
enables ceramide transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cerebroside transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables cholesterol transfer activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables diacylglyceride transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables diacylglycerol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables diacylglycerol binding ISO
Inferred from Sequence Orthology
more info
 
enables high-density lipoprotein particle binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables low-density lipoprotein particle binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidic acid transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidic acid transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylcholine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylcholine binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylcholine transfer activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phosphatidylcholine transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylcholine transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylethanolamine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylethanolamine binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylethanolamine transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylethanolamine transfer activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phosphatidylethanolamine transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylglycerol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylglycerol binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylglycerol transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol transfer activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phospholipid transfer activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipid transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables sphingomyelin transfer activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables sphingomyelin transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables very-low-density lipoprotein particle binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ceramide transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ceramide transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glycolipid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in high-density lipoprotein particle remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in high-density lipoprotein particle remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phospholipid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within vitamin E biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of high-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phospholipid transfer protein
Names
lipid transfer protein II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011125.2NP_035255.1  phospholipid transfer protein precursor

    See identical proteins and their annotated locations for NP_035255.1

    Status: VALIDATED

    Source sequence(s)
    AK148330, AK149730, U37226
    Consensus CDS
    CCDS17063.1
    UniProtKB/Swiss-Prot
    P55065
    UniProtKB/TrEMBL
    Q3UE59, Q3UFS5
    Related
    ENSMUSP00000061519.8, ENSMUST00000059954.14
    Conserved Domains (2) summary
    smart00328
    Location:25243
    BPI1; BPI/LBP/CETP N-terminal domain
    pfam02886
    Location:228464
    LBP_BPI_CETP_C; LBP / BPI / CETP family, C-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    164681438..164699628 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159615.1XP_036015508.1  phospholipid transfer protein isoform X1

    Conserved Domains (2) summary
    smart00328
    Location:25243
    BPI1; BPI/LBP/CETP N-terminal domain
    pfam02886
    Location:228464
    LBP_BPI_CETP_C; LBP / BPI / CETP family, C-terminal domain
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