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cyp-13A4 Putative cytochrome P450 CYP13A4 [ Caenorhabditis elegans ]

Gene ID: 188355, updated on 7-Sep-2023

Summary

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Gene symbol
cyp-13A4
Gene description
Putative cytochrome P450 CYP13A4
Primary source
WormBase:WBGene00011671
Locus tag
CELE_T10B9.1
See related
AllianceGenome:WB:WBGene00011671
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Human ortholog(s) of this gene implicated in several diseases, including Ghosal hematodiaphyseal syndrome; essential hypertension; familial Mediterranean fever; leukemia (multiple); and platelet-type bleeding disorder 14. Orthologous to several human genes including CYP3A7-CYP3A51P (CYP3A7-CYP3A51P readthrough); CYP3A4 (cytochrome P450 family 3 subfamily A member 4); and CYP3A43 (cytochrome P450 family 3 subfamily A member 43). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See cyp-13A4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
6
Sequence:
Chromosome: II; NC_003280.10 (9795756..9797740, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Putative cytochrome P450 CYP13A3 Neighboring gene pseudo Neighboring gene Putative cytochrome P450 CYP13A5 Neighboring gene Putative cytochrome P450 CYP13A6 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity. Cui Y, et al. Genome Biol, 2007. PMID 17592649, Free PMC Article
  2. Effects of sod gene overexpression and deletion mutation on the expression profiles of reporter genes of major detoxification pathways in Caenorhabditis elegans. Back P, et al. Exp Gerontol, 2010 Aug. PMID 20096764
  3. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Murphy CT, et al. Nature, 2003 Jul 17. PMID 12845331
  4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Putative cytochrome P450 CYP13A4
NP_496111.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    9795756..9797740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063710.3 → NP_496111.1  Putative cytochrome P450 CYP13A4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496111.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27513
    Conserved Domains (1) summary
    pfam00067
    Location:33 → 514
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q27513.1

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