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cyp-13A6 Putative cytochrome P450 CYP13A6 [ Caenorhabditis elegans ]

Gene ID: 188357, updated on 7-Sep-2023

Summary

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Gene symbol
cyp-13A6
Gene description
Putative cytochrome P450 CYP13A6
Primary source
WormBase:WBGene00011673
Locus tag
CELE_T10B9.3
See related
AllianceGenome:WB:WBGene00011673
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Human ortholog(s) of this gene implicated in several diseases, including Ghosal hematodiaphyseal syndrome; essential hypertension; familial Mediterranean fever; leukemia (multiple); and platelet-type bleeding disorder 14. Orthologous to several human genes including CYP3A4 (cytochrome P450 family 3 subfamily A member 4) and TBXAS1 (thromboxane A synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
6
Sequence:
Chromosome: II; NC_003280.10 (9800758..9802821, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Putative cytochrome P450 CYP13A4 Neighboring gene Putative cytochrome P450 CYP13A5 Neighboring gene ncRNA Neighboring gene Putative cytochrome P450 CYP13A7 Neighboring gene Putative cytochrome P450 CYP13A8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cytochrome P450s and short-chain dehydrogenases mediate the toxicogenomic response of PCB52 in the nematode Caenorhabditis elegans. Menzel R, et al. J Mol Biol, 2007 Jun 29. PMID 17499272
  2. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Putative cytochrome P450 CYP13A6
NP_496113.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    9800758..9802821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063712.4 → NP_496113.1  Putative cytochrome P450 CYP13A6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496113.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27515
    Conserved Domains (1) summary
    pfam00067
    Location:31 → 508
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q27515.1

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