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Pole2 polymerase (DNA directed), epsilon 2 (p59 subunit) [ Mus musculus (house mouse) ]

Gene ID: 18974, updated on 23-Jun-2021

Summary

Official Symbol
Pole2provided by MGI
Official Full Name
polymerase (DNA directed), epsilon 2 (p59 subunit)provided by MGI
Primary source
MGI:MGI:1197514
See related
Ensembl:ENSMUSG00000020974
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Broad expression in liver E14 (RPKM 11.5), liver E14.5 (RPKM 10.1) and 18 other tissues See more
Orthologs
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Genomic context

See Pole2 in Genome Data Viewer
Location:
12; 12 C2
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (69248547..69274979, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (69201773..69228205, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (70302766..70329177, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9330151L19 gene Neighboring gene mannoside acetylglucosaminyltransferase 2 Neighboring gene dynein, axonemal assembly factor 2 Neighboring gene kelch domain containing 1 Neighboring gene kelch domain containing 2 Neighboring gene nuclear export mediator factor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA-dependent DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in error-prone translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of epsilon DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of epsilon DNA polymerase complex ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DNA polymerase epsilon subunit 2
Names
DNA polymerase II subunit 2
DNA polymerase epsilon small subunit
DNA polymerase epsilon subunit B
NP_035263.1
XP_006515661.1
XP_006515662.1
XP_011242320.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011133.2NP_035263.1  DNA polymerase epsilon subunit 2

    See identical proteins and their annotated locations for NP_035263.1

    Status: PROVISIONAL

    Source sequence(s)
    AF036898, AK077592
    Consensus CDS
    CCDS36463.1
    UniProtKB/Swiss-Prot
    O54956
    Related
    ENSMUSP00000021359.6, ENSMUST00000021359.7
    Conserved Domains (2) summary
    pfam04042
    Location:288489
    DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
    pfam12213
    Location:373
    Dpoe2NT; DNA polymerases epsilon N terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    69248547..69274979 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244018.2XP_011242320.1  DNA polymerase epsilon subunit 2 isoform X1

    Conserved Domains (1) summary
    pfam04042
    Location:228429
    DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
  2. XM_006515599.1XP_006515662.1  DNA polymerase epsilon subunit 2 isoform X3

    Conserved Domains (1) summary
    pfam04042
    Location:40241
    DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
  3. XM_006515598.4XP_006515661.1  DNA polymerase epsilon subunit 2 isoform X2

    Conserved Domains (2) summary
    pfam12213
    Location:474
    Dpoe2NT; DNA polymerases epsilon N terminal
    cl13995
    Location:288404
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
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