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Cnot7 CCR4-NOT transcription complex, subunit 7 [ Mus musculus (house mouse) ]

Gene ID: 18983, updated on 14-Sep-2021

Summary

Official Symbol
Cnot7provided by MGI
Official Full Name
CCR4-NOT transcription complex, subunit 7provided by MGI
Primary source
MGI:MGI:1298230
See related
Ensembl:ENSMUSG00000031601
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Caf; Caf1; Pop2; CAF-1; AU022737
Expression
Broad expression in CNS E14 (RPKM 22.0), CNS E18 (RPKM 21.1) and 23 other tissues See more
Orthologs
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Genomic context

See Cnot7 in Genome Data Viewer
Location:
8; 8 A4
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (40945579..40968888, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (40492538..40515847, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (41578390..41596658, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 20 Neighboring gene microRNA 7666 Neighboring gene mitochondrial calcium uptake family, member 3 Neighboring gene zinc finger, DHHC domain containing 2 Neighboring gene vacuolar protein sorting 37A Neighboring gene myotubularin related protein 7 Neighboring gene a disintegrin and metallopeptidase domain 24 (testase 1)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5'-exoribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables exoribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables poly(A)-specific ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables poly(A)-specific ribonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables poly(A)-specific ribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within P-body assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within deadenylation-dependent decapping of nuclear-transcribed mRNA IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within deadenylation-dependent decapping of nuclear-transcribed mRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in exonucleolytic catabolism of deadenylated mRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in exonucleolytic catabolism of deadenylated mRNA ISO
Inferred from Sequence Orthology
more info
 
involved_in gene silencing by RNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nuclear-transcribed mRNA poly(A) tail shortening IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of CCR4-NOT complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of CCR4-NOT complex ISO
Inferred from Sequence Orthology
more info
 
part_of CCR4-NOT core complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in P-body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
CCR4-NOT transcription complex subunit 7
Names
CCR4-associated factor 1
POP2 homolog
catabolite repressor protein (CCR4)-associative factor 1
NP_001258471.1
NP_001258472.1
NP_001348867.1
NP_001348868.1
NP_035265.1
XP_006509370.1
XP_036009723.1
XP_036009724.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271542.1NP_001258471.1  CCR4-NOT transcription complex subunit 7 isoform 1

    See identical proteins and their annotated locations for NP_001258471.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same isoform (1).
    Source sequence(s)
    AC118012, AK135669, AK147048
    Consensus CDS
    CCDS22253.1
    UniProtKB/Swiss-Prot
    Q60809
    UniProtKB/TrEMBL
    Q543X5
    Related
    ENSMUSP00000122933.2, ENSMUST00000132032.8
    Conserved Domains (1) summary
    cl23804
    Location:1279
    CAF1; CAF1 family ribonuclease
  2. NM_001271543.1NP_001258472.1  CCR4-NOT transcription complex subunit 7 isoform 2

    See identical proteins and their annotated locations for NP_001258472.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AC118012
    Consensus CDS
    CCDS72114.1
    UniProtKB/TrEMBL
    Q3TLK9
    Related
    ENSMUSP00000119319.2, ENSMUST00000135269.8
    Conserved Domains (1) summary
    cl23804
    Location:1215
    CAF1; CAF1 family ribonuclease
  3. NM_001361938.1NP_001348867.1  CCR4-NOT transcription complex subunit 7 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC118012, AK147048, CN663584
    Consensus CDS
    CCDS22253.1
    Related
    ENSMUSP00000117304.2, ENSMUST00000149992.2
    Conserved Domains (1) summary
    cl23804
    Location:1279
    CAF1; CAF1 family ribonuclease
  4. NM_001361939.1NP_001348868.1  CCR4-NOT transcription complex subunit 7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC118012, AK147048, CJ166755
    Conserved Domains (1) summary
    cl23804
    Location:1292
    CAF1; CAF1 family ribonuclease
  5. NM_011135.5NP_035265.1  CCR4-NOT transcription complex subunit 7 isoform 1

    See identical proteins and their annotated locations for NP_035265.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform . Variants 1, 2 and 4 encode the same isoform (1).
    Source sequence(s)
    AC118012, AK147048, CJ166755
    Consensus CDS
    CCDS22253.1
    UniProtKB/Swiss-Prot
    Q60809
    UniProtKB/TrEMBL
    Q543X5
    Related
    ENSMUSP00000034012.4, ENSMUST00000034012.10
    Conserved Domains (1) summary
    cl23804
    Location:1279
    CAF1; CAF1 family ribonuclease

RNA

  1. NR_155265.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC118012, AK147048, CJ166755, CN663584, DV653062
  2. NR_155266.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC118012, AK147048, CN663584, DV653062

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    40945579..40968888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153830.1XP_036009723.1  CCR4-NOT transcription complex subunit 7 isoform X1

    Conserved Domains (1) summary
    cl23804
    Location:1228
    CAF1; CAF1 family ribonuclease
  2. XM_036153831.1XP_036009724.1  CCR4-NOT transcription complex subunit 7 isoform X2

    Conserved Domains (1) summary
    cl23804
    Location:1215
    CAF1; CAF1 family ribonuclease
  3. XM_006509307.3XP_006509370.1  CCR4-NOT transcription complex subunit 7 isoform X3

    Conserved Domains (1) summary
    cl23804
    Location:1173
    CAF1; CAF1 family ribonuclease

RNA

  1. XR_378909.4 RNA Sequence

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