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Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) [ Mus musculus (house mouse) ]

Gene ID: 19058, updated on 20-Jul-2021

Summary

Official Symbol
Ppp3r1provided by MGI
Official Full Name
protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)provided by MGI
Primary source
MGI:MGI:107172
See related
Ensembl:ENSMUSG00000033953
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CaN; Cnb; Cnb1; CaNB1; MCIP1
Expression
Broad expression in adrenal adult (RPKM 124.5), cortex adult (RPKM 39.3) and 19 other tissues See more
Orthologs
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Genomic context

See Ppp3r1 in Genome Data Viewer
Location:
11; 11 A2
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (17109298..17150380)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (17159298..17200380)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (17059301..17100383)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene cannabinoid receptor interacting protein 1 Neighboring gene 60S ribosomal protein L39 pseudogene Neighboring gene partner of NOB1 homolog Neighboring gene dynein axonemal assembly factor 10

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent protein serine/threonine phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
 
enables cyclosporin A binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Schwann cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within branching involved in blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within calcineurin-NFAT signaling cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myelination in peripheral nervous system IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of calcineurin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of calcineurin complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in parallel fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in parallel fiber to Purkinje cell synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
calcineurin subunit B type 1
Names
PP2B beta 1
protein phosphatase 2B regulatory subunit 1
protein phosphatase 3 regulatory subunit B alpha
NP_077779.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024459.2NP_077779.2  calcineurin subunit B type 1

    See identical proteins and their annotated locations for NP_077779.2

    Status: VALIDATED

    Source sequence(s)
    AK160938, BY137249
    Consensus CDS
    CCDS24448.1
    UniProtKB/Swiss-Prot
    Q63810
    Related
    ENSMUSP00000099944.5, ENSMUST00000102880.5
    Conserved Domains (1) summary
    COG5126
    Location:13157
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    17109298..17150380
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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