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Prom1 prominin 1 [ Mus musculus (house mouse) ]

Gene ID: 19126, updated on 28-Nov-2021

Summary

Official Symbol
Prom1provided by MGI
Official Full Name
prominin 1provided by MGI
Primary source
MGI:MGI:1100886
See related
Ensembl:ENSMUSG00000029086
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prom; AC133; CD133; Prom-1; Proml1; 4932416E19Rik
Expression
Broad expression in genital fat pad adult (RPKM 29.5), testis adult (RPKM 13.0) and 15 other tissues See more
Orthologs
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Genomic context

See Prom1 in Genome Data Viewer
Location:
5; 5 B3
Exon count:
32
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (44150963..44260850, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (43993621..44102047, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (44384861..44492975, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L15 pseudogene Neighboring gene fibroblast growth factor binding protein 1 Neighboring gene predicted gene, 35900 Neighboring gene predicted gene 42427

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actinin binding ISO
Inferred from Sequence Orthology
more info
 
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
 
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in brush border IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microvillus IDA
Inferred from Direct Assay
more info
PubMed 
located_in photoreceptor outer segment IDA
Inferred from Direct Assay
more info
PubMed 
located_in photoreceptor outer segment membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in prominosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in prominosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in stereocilium IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
prominin-1
Names
antigen AC133 homolog
prominin-like 1
prominin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163577.1NP_001157049.1  prominin-1 isoform s2 precursor

    See identical proteins and their annotated locations for NP_001157049.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (s2).
    Source sequence(s)
    AC102476, AK029921, BC028286, CJ054003, CX224587, EH108160
    Consensus CDS
    CCDS51494.1
    UniProtKB/TrEMBL
    G5E8G5, Q8CDK8, Q8R056
    Related
    ENSMUSP00000073751.7, ENSMUST00000074113.13
    Conserved Domains (1) summary
    pfam05478
    Location:19822
    Prominin
  2. NM_001163578.1NP_001157050.1  prominin-1 isoform s3 precursor

    See identical proteins and their annotated locations for NP_001157050.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternative in-frame exon in the 5' coding region and has multiple differences in the presence and absence of exons at its 3' end, compared to variant 2. The resulting isoform (s3) lacks a 9 aa segment near the N-terminus and has a shorter and distinct C-terminus, compared to isoform s2. The full structure of the 5' UTR for this variant has not been determined.
    Source sequence(s)
    AK030027
    Consensus CDS
    CCDS51493.1
    UniProtKB/Swiss-Prot
    O54990
    UniProtKB/TrEMBL
    A0A0G2JDH9
    Related
    ENSMUSP00000084709.5, ENSMUST00000087442.11
    Conserved Domains (3) summary
    TIGR04527
    Location:264445
    mycoplas_twoTM; two transmembrane protein
    pfam02465
    Location:248298
    FliD_N; Flagellar hook-associated protein 2 N-terminus
    pfam05478
    Location:19813
    Prominin; Prominin
  3. NM_001163581.1NP_001157053.1  prominin-1 isoform s4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks multiple alternative in-frame exons in the 5' coding region and has multiple differences in the presence and absence of exons at its 3' end, compared to variant 2. The resulting isoform (s4) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform s2. The full structure of the 5' UTR for this variant has not been determined.
    Source sequence(s)
    AK030027
    Consensus CDS
    CCDS80275.1
    UniProtKB/Swiss-Prot
    O54990
    UniProtKB/TrEMBL
    A0A0G2JE50
    Related
    ENSMUSP00000142632.2, ENSMUST00000197706.5
    Conserved Domains (3) summary
    TIGR04527
    Location:259415
    mycoplas_twoTM; two transmembrane protein
    pfam02465
    Location:243293
    FliD_N; Flagellar hook-associated protein 2 N-terminus
    pfam05478
    Location:19783
    Prominin; Prominin
  4. NM_001163582.1NP_001157054.1  prominin-1 isoform s5 precursor

    See identical proteins and their annotated locations for NP_001157054.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks multiple alternative in-frame exons in the 5' coding region and has multiple differences in the presence and absence of exons at its 3' end, compared to variant 2. The resulting isoform (s5) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform s2. The full structure of the 5' UTR for this variant has not been determined.
    Source sequence(s)
    AK030027
    Consensus CDS
    CCDS51491.1
    UniProtKB/Swiss-Prot
    O54990
    UniProtKB/TrEMBL
    A0A0R4J0B0
    Related
    ENSMUSP00000030973.8, ENSMUST00000030973.12
    Conserved Domains (3) summary
    TIGR04527
    Location:264420
    mycoplas_twoTM; two transmembrane protein
    pfam02465
    Location:248298
    FliD_N; Flagellar hook-associated protein 2 N-terminus
    pfam05478
    Location:19788
    Prominin; Prominin
  5. NM_001163583.1NP_001157055.1  prominin-1 isoform s6 precursor

    See identical proteins and their annotated locations for NP_001157055.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternative in-frame exon in the 5' coding region and has multiple differences in the presence and absence of exons at its 3' end, compared to variant 2. The resulting isoform (s6) lacks a 9 aa segment near the N-terminus and has a shorter and distinct C-terminus, compared to isoform s2. The full structure of the 5' UTR for this variant has not been determined.
    Source sequence(s)
    AC102476, AK030027
    UniProtKB/Swiss-Prot
    O54990
    Conserved Domains (3) summary
    TIGR04527
    Location:264445
    mycoplas_twoTM; two transmembrane protein
    pfam02465
    Location:248298
    FliD_N; Flagellar hook-associated protein 2 N-terminus
    pfam05478
    Location:19813
    Prominin; Prominin
  6. NM_001163584.1NP_001157056.1  prominin-1 isoform s7 precursor

    See identical proteins and their annotated locations for NP_001157056.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternative in-frame exon in the 5' coding region and lacks multiple exons at its 3' end, compared to variant 2. The resulting isoform (s7) lacks a 9 aa segment near the N-terminus and has a shorter C-terminus, compared to isoform s2. The full structure of the 5' UTR for this variant has not been determined.
    Source sequence(s)
    AK029921, BC028286
    Consensus CDS
    CCDS51492.1
    UniProtKB/TrEMBL
    Q8CDK8, Q8R056
    Related
    ENSMUSP00000136483.2, ENSMUST00000177946.8
    Conserved Domains (1) summary
    pfam05478
    Location:19813
    Prominin
  7. NM_001163585.1NP_001157057.1  prominin-1 isoform s8 precursor

    See identical proteins and their annotated locations for NP_001157057.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks an alternative in-frame exon in the 5' coding region and has multiple differences in the presence and absence of exons at its 3' end, compared to variant 2. The resulting isoform (s8) lacks a 9 aa segment near the N-terminus and has a shorter C-terminus, compared to isoform s2. The full structure of the 5' UTR for this variant has not been determined.
    Source sequence(s)
    BC028286
    Consensus CDS
    CCDS51495.1
    UniProtKB/TrEMBL
    Q8R056
    Related
    ENSMUSP00000137557.2, ENSMUST00000179059.8
    Conserved Domains (3) summary
    TIGR04527
    Location:273454
    mycoplas_twoTM; two transmembrane protein
    pfam02465
    Location:257307
    FliD_N; Flagellar hook-associated protein 2 N-terminus
    pfam05478
    Location:19828
    Prominin; Prominin
  8. NM_008935.2NP_032961.2  prominin-1 isoform s1 precursor

    See identical proteins and their annotated locations for NP_032961.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternative in-frame exon in the 5' coding region, compared to variant 2. The resulting isoform (s1) lacks a 9 aa segment near the N-terminus, compared to isoform s2.
    Source sequence(s)
    AC102476, AK029921, BC028286, CJ054003, EH108160
    Consensus CDS
    CCDS39082.1
    UniProtKB/TrEMBL
    G3X9J8, Q8CDK8, Q8R056
    Related
    ENSMUSP00000084707.5, ENSMUST00000087441.11
    Conserved Domains (1) summary
    pfam05478
    Location:19813
    Prominin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    44150963..44260850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503786.2XP_006503849.1  prominin-1 isoform X2

    Conserved Domains (1) summary
    pfam05478
    Location:19822
    Prominin
  2. XM_017320724.3XP_017176213.1  prominin-1 isoform X1

    UniProtKB/TrEMBL
    G5E8G5
    Conserved Domains (1) summary
    pfam05478
    Location:19822
    Prominin
  3. XM_036164904.1XP_036020797.1  prominin-1 isoform X8

    Conserved Domains (1) summary
    pfam05478
    Location:7469
    Prominin
  4. XM_036164898.1XP_036020791.1  prominin-1 isoform X3

    Conserved Domains (1) summary
    pfam05478
    Location:19813
    Prominin
  5. XM_017320720.3XP_017176209.1  prominin-1 isoform X1

    UniProtKB/TrEMBL
    G5E8G5
    Conserved Domains (1) summary
    pfam05478
    Location:19822
    Prominin
  6. XM_006503791.4XP_006503854.1  prominin-1 isoform X8

    Conserved Domains (1) summary
    pfam05478
    Location:7469
    Prominin
  7. XM_017320723.3XP_017176212.1  prominin-1 isoform X1

    UniProtKB/TrEMBL
    G5E8G5
    Conserved Domains (1) summary
    pfam05478
    Location:19822
    Prominin
  8. XM_017320722.3XP_017176211.1  prominin-1 isoform X1

    UniProtKB/TrEMBL
    G5E8G5
    Conserved Domains (1) summary
    pfam05478
    Location:19822
    Prominin
  9. XM_030254207.2XP_030110067.1  prominin-1 isoform X3

    Conserved Domains (1) summary
    pfam05478
    Location:19813
    Prominin
  10. XM_006503789.3XP_006503852.1  prominin-1 isoform X7

    See identical proteins and their annotated locations for XP_006503852.1

    UniProtKB/TrEMBL
    Q8CDK8
    Conserved Domains (1) summary
    pfam05478
    Location:19813
    Prominin
  11. XM_006503790.5XP_006503853.1  prominin-1 isoform X7

    See identical proteins and their annotated locations for XP_006503853.1

    UniProtKB/TrEMBL
    Q8CDK8
    Related
    ENSMUSP00000129909.2, ENSMUST00000165909.8
    Conserved Domains (1) summary
    pfam05478
    Location:19813
    Prominin
  12. XM_036164903.1XP_036020796.1  prominin-1 isoform X6

    Conserved Domains (1) summary
    pfam05478
    Location:19813
    Prominin
  13. XM_017320725.2XP_017176214.1  prominin-1 isoform X4

    Conserved Domains (1) summary
    pfam05478
    Location:19822
    Prominin
  14. XM_006503788.2XP_006503851.1  prominin-1 isoform X5

    Conserved Domains (1) summary
    pfam05478
    Location:19822
    Prominin
  15. XM_036164902.1XP_036020795.1  prominin-1 isoform X5

    Conserved Domains (1) summary
    pfam05478
    Location:19822
    Prominin
  16. XM_036164899.1XP_036020792.1  prominin-1 isoform X4

    Conserved Domains (1) summary
    pfam05478
    Location:19822
    Prominin
  17. XM_036164900.1XP_036020793.1  prominin-1 isoform X5

    Conserved Domains (1) summary
    pfam05478
    Location:19822
    Prominin
  18. XM_036164905.1XP_036020798.1  prominin-1 isoform X9

    Conserved Domains (1) summary
    pfam05478
    Location:7469
    Prominin
  19. XM_036164901.1XP_036020794.1  prominin-1 isoform X5

    Conserved Domains (1) summary
    pfam05478
    Location:19822
    Prominin
  20. XM_036164906.1XP_036020799.1  prominin-1 isoform X9

    Conserved Domains (1) summary
    pfam05478
    Location:7469
    Prominin

RNA

  1. XR_001784642.2 RNA Sequence

  2. XR_001784643.3 RNA Sequence

  3. XR_001784640.2 RNA Sequence

  4. XR_004942456.1 RNA Sequence

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