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Akr1c14 aldo-keto reductase family 1, member C14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 191574, updated on 3-Jan-2019

Summary

Official Symbol
Akr1c14provided by RGD
Official Full Name
aldo-keto reductase family 1, member C14provided by RGD
Primary source
RGD:708361
See related
Ensembl:ENSRNOG00000017672
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Akr1c9
Summary
catalyzes the conversion of 5 alpha-dihydrotestosterone to 3 alpha-androstanediol in steroid metabolism [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 4912.5), Adrenal (RPKM 393.8) and 1 other tissue See more

Genomic context

See Akr1c14 in Genome Data Viewer
Location:
17q12.2
Exon count:
9
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (69806095..69827125, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (71510873..71530255, complement)

Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1, member C3 Neighboring gene uncharacterized LOC103694124 Neighboring gene aldo-keto reductase family 1, member C15 Neighboring gene uncharacterized LOC108348583

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
alcohol dehydrogenase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alditol:NADP+ 1-oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
androsterone dehydrogenase (B-specific) activity IEA
Inferred from Electronic Annotation
more info
 
androsterone dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ketosteroid monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
steroid dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
steroid dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
daunorubicin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
doxorubicin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hippocampus development IEP
Inferred from Expression Pattern
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
progesterone metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prostaglandin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
steroid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
steroid metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
3-alpha-hydroxysteroid dehydrogenase
Names
3-alpha-HSD
hydroxyprostaglandin dehydrogenase
steroid 3-alpha-dehydrogenase
NP_612556.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138547.3NP_612556.1  3-alpha-hydroxysteroid dehydrogenase

    See identical proteins and their annotated locations for NP_612556.1

    Status: VALIDATED

    Source sequence(s)
    AABR07028443, BC091123
    UniProtKB/Swiss-Prot
    P23457
    Related
    ENSRNOP00000023835.4, ENSRNOT00000023835.6
    Conserved Domains (2) summary
    COG0656
    Location:7305
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:11297
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

    Range
    69806095..69827125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000085.1 Alternate Rn_Celera

    Range
    65671422..65688400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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