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Psma3 proteasome subunit alpha 3 [ Mus musculus (house mouse) ]

Gene ID: 19167, updated on 22-Aug-2021

Summary

Official Symbol
Psma3provided by MGI
Official Full Name
proteasome subunit alpha 3provided by MGI
Primary source
MGI:MGI:104883
See related
Ensembl:ENSMUSG00000060073
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lmp; Lmpc8
Expression
Ubiquitous expression in placenta adult (RPKM 35.7), CNS E11.5 (RPKM 28.9) and 25 other tissues See more
Orthologs
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Genomic context

See Psma3 in Genome Data Viewer
Location:
12; 12 C2
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (71016057..71042651)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (70969283..70995877)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (72075610..72095924)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ARP10 actin-related protein 10 Neighboring gene nuclear encoded tRNA lysine 17 (anticodon CTT) Neighboring gene RIKEN cDNA 3110056K07 gene Neighboring gene AT rich interactive domain 4A (RBP1-like) Neighboring gene translocase of outer mitochondrial membrane 20-like Neighboring gene predicted gene, 32906

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in proteasomal protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteolysis involved in cellular protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of proteasome core complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome core complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
proteasome subunit alpha type-3
Names
macropain subunit C8
multicatalytic endopeptidase complex subunit C8
proteasome (prosome, macropain) subunit, alpha type 3
proteasome component C8
proteasome subunit K
NP_001297524.1
NP_001297525.1
NP_035314.3
XP_017170485.1
XP_030102476.1
XP_030102477.1
XP_036013150.1
XP_036013151.1
XP_036013152.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310595.1NP_001297524.1  proteasome subunit alpha type-3 isoform b

    See identical proteins and their annotated locations for NP_001297524.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start site, compared to variant 1. The encoded isoform (b) has a shorter N-terminus compared to isoform a. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC132325, AI303320, AK169577, BY159585
    Consensus CDS
    CCDS79119.1
    UniProtKB/TrEMBL
    E0CX62, Q3TEL1
    Conserved Domains (1) summary
    cl00467
    Location:1142
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
  2. NM_001310596.1NP_001297525.1  proteasome subunit alpha type-3 isoform b

    See identical proteins and their annotated locations for NP_001297525.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start site, compared to variant 1. The encoded isoform (b) has a shorter N-terminus compared to isoform a. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC132325
    Consensus CDS
    CCDS79119.1
    UniProtKB/TrEMBL
    E0CX62
    Conserved Domains (1) summary
    cl00467
    Location:1142
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
  3. NM_011184.5NP_035314.3  proteasome subunit alpha type-3 isoform a

    See identical proteins and their annotated locations for NP_035314.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC132325, AI303320, AK168495, BY159585
    Consensus CDS
    CCDS25961.1
    UniProtKB/Swiss-Prot
    O70435
    UniProtKB/TrEMBL
    Q58EV4
    Related
    ENSMUSP00000125548.2, ENSMUST00000160027.8
    Conserved Domains (1) summary
    cd03751
    Location:5217
    proteasome_alpha_type_3; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    71016057..71042651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314996.2XP_017170485.1  proteasome subunit alpha type-3 isoform X1

    UniProtKB/Swiss-Prot
    O70435
    UniProtKB/TrEMBL
    Q58EV4
    Conserved Domains (1) summary
    cd03751
    Location:5217
    proteasome_alpha_type_3; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...
  2. XM_030246616.1XP_030102476.1  proteasome subunit alpha type-3 isoform X1

    Conserved Domains (1) summary
    cd03751
    Location:5217
    proteasome_alpha_type_3; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...
  3. XM_036157257.1XP_036013150.1  proteasome subunit alpha type-3 isoform X2

    Conserved Domains (1) summary
    cd03751
    Location:5195
    proteasome_alpha_type_3; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...
  4. XM_036157259.1XP_036013152.1  proteasome subunit alpha type-3 isoform X4

    Conserved Domains (1) summary
    cl00467
    Location:1120
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
  5. XM_036157258.1XP_036013151.1  proteasome subunit alpha type-3 isoform X4

    Conserved Domains (1) summary
    cl00467
    Location:1120
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
  6. XM_030246617.2XP_030102477.1  proteasome subunit alpha type-3 isoform X3

    Related
    ENSMUSP00000124894.3, ENSMUST00000160864.8
    Conserved Domains (1) summary
    cl00467
    Location:1142
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
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