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Pter phosphotriesterase related [ Mus musculus (house mouse) ]

Gene ID: 19212, updated on 26-Mar-2024

Summary

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Official Symbol
Pterprovided by MGI
Official Full Name
phosphotriesterase relatedprovided by MGI
Primary source
MGI:MGI:107372
See related
Ensembl:ENSMUSG00000026730 AllianceGenome:MGI:107372
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mpr56-1
Summary
Predicted to enable hydrolase activity, acting on ester bonds and zinc ion binding activity. Predicted to be involved in catabolic process. Is expressed in liver lobe; urinary system; and ventricular layer. Orthologous to human PTER (phosphotriesterase related). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 33.8), frontal lobe adult (RPKM 10.9) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 A1; 2 9.63 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (12928828..13008265)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (12924037..13003454)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5886 Neighboring gene MINDY lysine 48 deubiquitinase 3 Neighboring gene STARR-seq mESC enhancer starr_03692 Neighboring gene STARR-seq mESC enhancer starr_03694 Neighboring gene predicted gene 13321 Neighboring gene STARR-seq mESC enhancer starr_03695 Neighboring gene STARR-seq mESC enhancer starr_03696 Neighboring gene STARR-seq mESC enhancer starr_03697 Neighboring gene STARR-positive B cell enhancer ABC_E4415 Neighboring gene STARR-seq mESC enhancer starr_03698 Neighboring gene predicted gene, 52597 Neighboring gene C1q-like 3 Neighboring gene STARR-seq mESC enhancer starr_03699 Neighboring gene Ras suppressor protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E5887 Neighboring gene STARR-positive B cell enhancer ABC_E1000 Neighboring gene STARR-positive B cell enhancer ABC_E5888 Neighboring gene STARR-seq mESC enhancer starr_03701 Neighboring gene STARR-seq mESC enhancer starr_03702 Neighboring gene predicted gene 13270 Neighboring gene cubilin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A mouse kidney- and liver-expressed cDNA having homology with a prokaryotic parathion hydrolase (phosphotriesterase)-encoding gene: abnormal expression in injured and polycystic kidneys. Hou X, et al. Gene, 1996 Feb 12. PMID 8654936
  2. Recent acquisition of imprinting at the rodent Sfmbt2 locus correlates with insertion of a large block of miRNAs. Wang Q, et al. BMC Genomics, 2011 Apr 21. PMID 21510876, Free PMC Article
  3. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in catabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphotriesterase-related protein
Names
parathion hydrolase (phosphotriesterase)-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305436.1 → NP_001292365.1  phosphotriesterase-related protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the UTRs and has multiple coding region differences that result in use of a downstream start codon and a frame-shift in the 3' coding region compared to variant 1. It encodes isoform 3, which has a shorter N-terminus and a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AI021584, AK012076, AK075604, AL929209, BM115320, BY241873, BY704600, U28016
    Consensus CDS
    CCDS84471.1
    UniProtKB/TrEMBL
    A2AUR3
    Related
    ENSMUSP00000028063.5, ENSMUST00000028063.7
    Conserved Domains (1) summary
    cl00281
    Location:15 → 257
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

  2. NM_001305437.1 → NP_001292366.1  phosphotriesterase-related protein isoform 1

    See identical proteins and their annotated locations for NP_001292366.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK075604, AL929209, BB854955, BB868274, BY704600, U28016
    UniProtKB/TrEMBL
    A2AUR3
    Conserved Domains (1) summary
    pfam02126
    Location:27 → 359
    PTE; Phosphotriesterase family

  3. NM_008961.3 → NP_032987.1  phosphotriesterase-related protein isoform 2

    See identical proteins and their annotated locations for NP_032987.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks an exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK075604, AL929209, BB868274, BY704600, U28016
    Consensus CDS
    CCDS15691.1
    UniProtKB/Swiss-Prot
    A2AUR4, A2AUR6, Q60866, Q8BTA3
    UniProtKB/TrEMBL
    A2AUR3
    Related
    ENSMUSP00000117009.2, ENSMUST00000134794.8
    Conserved Domains (1) summary
    pfam02126
    Location:15 → 347
    PTE; Phosphotriesterase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    12928828..13008265
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497402.3 → XP_006497465.1  phosphotriesterase-related protein isoform X3

    UniProtKB/TrEMBL
    A2AUR5
    Related
    ENSMUSP00000110444.4, ENSMUST00000114796.9
    Conserved Domains (1) summary
    cl00281
    Location:15 → 279
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

  2. XM_006497401.3 → XP_006497464.1  phosphotriesterase-related protein isoform X2

    UniProtKB/TrEMBL
    A2AUR5
    Conserved Domains (1) summary
    cl00281
    Location:27 → 291
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

  3. XM_017316438.2 → XP_017171927.1  phosphotriesterase-related protein isoform X1

    UniProtKB/TrEMBL
    A2AUR3
    Conserved Domains (1) summary
    pfam02126
    Location:27 → 359
    PTE; Phosphotriesterase family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60866.1 GenPept UniProtKB/Swiss-Prot:Q60866

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