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Mvd mevalonate (diphospho) decarboxylase [ Mus musculus (house mouse) ]

Gene ID: 192156, updated on 5-Jan-2022

Summary

Official Symbol
Mvdprovided by MGI
Official Full Name
mevalonate (diphospho) decarboxylaseprovided by MGI
Primary source
MGI:MGI:2179327
See related
Ensembl:ENSMUSG00000006517
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mpd; C78718
Summary
Predicted to enable Hsp70 protein binding activity; diphosphomevalonate decarboxylase activity; and protein homodimerization activity. Predicted to be involved in isopentenyl diphosphate biosynthetic process, mevalonate pathway and positive regulation of cell population proliferation. Predicted to act upstream of or within cholesterol biosynthetic process. Located in cytosol. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human MVD (mevalonate diphosphate decarboxylase). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in CNS E18 (RPKM 27.0), kidney adult (RPKM 26.1) and 28 other tissues See more
Orthologs
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Genomic context

See Mvd in Genome Data Viewer
Location:
8; 8 E1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (123160335..123170161, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (122433596..122443422, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (124957496..124967322, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene interleukin 17C Neighboring gene cytochrome b-245, alpha polypeptide Neighboring gene predicted gene, 53466 Neighboring gene predicted gene, 51557 Neighboring gene RIKEN cDNA 9330133O14 gene Neighboring gene predicted gene, 20735 Neighboring gene snail family zinc finger 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables diphosphomevalonate decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables diphosphomevalonate decarboxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisomal matrix ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
diphosphomevalonate decarboxylase
Names
MDDase
mevalonate pyrophosphate decarboxylase
NP_619597.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138656.2NP_619597.2  diphosphomevalonate decarboxylase

    See identical proteins and their annotated locations for NP_619597.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AK089354, AK134803, AL591003
    Consensus CDS
    CCDS22738.1
    UniProtKB/Swiss-Prot
    Q99JF5
    UniProtKB/TrEMBL
    Q3UYC1
    Related
    ENSMUSP00000006692.5, ENSMUST00000006692.6
    Conserved Domains (1) summary
    PLN02407
    Location:9338
    PLN02407; diphosphomevalonate decarboxylase

RNA

  1. NR_028354.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK089354, AK153439, AL591003
    Related
    ENSMUST00000211883.2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    123160335..123170161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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