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Mvd mevalonate (diphospho) decarboxylase [ Mus musculus (house mouse) ]

Gene ID: 192156, updated on 5-Mar-2024

Summary

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Official Symbol
Mvdprovided by MGI
Official Full Name
mevalonate (diphospho) decarboxylaseprovided by MGI
Primary source
MGI:MGI:2179327
See related
Ensembl:ENSMUSG00000006517 AllianceGenome:MGI:2179327
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mpd
Summary
Predicted to enable Hsp70 protein binding activity; diphosphomevalonate decarboxylase activity; and protein homodimerization activity. Predicted to be involved in isopentenyl diphosphate biosynthetic process, mevalonate pathway and positive regulation of cell population proliferation. Predicted to act upstream of or within cholesterol biosynthetic process. Located in cytosol. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human MVD (mevalonate diphosphate decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 27.0), kidney adult (RPKM 26.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 E1; 8 71.05 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (123160335..123170161, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (122433596..122443422, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene interleukin 17C Neighboring gene cytochrome b-245, alpha polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E9324 Neighboring gene STARR-positive B cell enhancer ABC_E8269 Neighboring gene STARR-positive B cell enhancer ABC_E1776 Neighboring gene predicted gene, 53466 Neighboring gene predicted gene, 51557 Neighboring gene RIKEN cDNA 9330133O14 gene Neighboring gene STARR-positive B cell enhancer ABC_E567 Neighboring gene predicted gene, 20735 Neighboring gene snail family zinc finger 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Subcellular distribution of mouse mevalonate pyrophosphate decarboxylase. Michihara A, et al. Biol Pharm Bull, 2003 May. PMID 12736493
  2. Mortalin-MPD (mevalonate pyrophosphate decarboxylase) interactions and their role in control of cellular proliferation. Wadhwa R, et al. Biochem Biophys Res Commun, 2003 Mar 21. PMID 12646231
  3. Normalization of Hepatic Homeostasis in the Npc1(nmf164) Mouse Model of Niemann-Pick Type C Disease Treated with the Histone Deacetylase Inhibitor Vorinostat. Munkacsi AB, et al. J Biol Chem, 2017 Mar 17. PMID 28031458, Free PMC Article
  4. A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo. Şişecioğlu M, et al. J Lipid Res, 2015 Aug. PMID 26108225, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results identify mevalonate pyrophosphate decarboxylase (MPD) as a binding partner of mortalin-2.
    Title: Mortalin-MPD (mevalonate pyrophosphate decarboxylase) interactions and their role in control of cellular proliferation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables diphosphomevalonate decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables diphosphomevalonate decarboxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in isoprenoid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisomal matrix ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
diphosphomevalonate decarboxylase
Names
MDDase
mevalonate pyrophosphate decarboxylase
NP_619597.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138656.2 → NP_619597.2  diphosphomevalonate decarboxylase

    See identical proteins and their annotated locations for NP_619597.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AK089354, AK134803, AL591003
    Consensus CDS
    CCDS22738.1
    UniProtKB/Swiss-Prot
    Q3TCD8, Q8BTM4, Q922D7, Q99JF5
    UniProtKB/TrEMBL
    Q3UYC1
    Related
    ENSMUSP00000006692.5, ENSMUST00000006692.6
    Conserved Domains (1) summary
    PLN02407
    Location:9 → 338
    PLN02407; diphosphomevalonate decarboxylase

RNA

  1. NR_028354.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK089354, AK153439, AL591003
    Related
    ENSMUST00000211883.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    123160335..123170161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99JF5.2 GenPept UniProtKB/Swiss-Prot:Q99JF5

Gene LinkOut

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