Ptger3 prostaglandin E receptor 3 (subtype EP3) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptger3provided by MGI
Official Full Name: prostaglandin E receptor 3 (subtype EP3)provided by MGI
Primary source: MGI:MGI:97795
See related: Ensembl:ENSMUSG00000040016 AllianceGenome:MGI:97795
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EP3; Pgerep3; Ptgerep3
Summary: Enables prostaglandin E receptor activity. Involved in positive regulation of fever generation. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; bicarbonate transport; and fever generation. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human PTGER3 (prostaglandin E receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in mammary gland adult (RPKM 43.5), adrenal adult (RPKM 43.0) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 H4; 3 81.32 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (157272459..157350392)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (157566821..157644758)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Posttranscriptional regulation of the prostaglandin E receptor spliced-isoform EP3-gamma and its implication in pancreatic beta-cell failure.
Title: Posttranscriptional regulation of the prostaglandin E receptor spliced-isoform EP3-γ and its implication in pancreatic β-cell failure.
Prostaglandin EP3 receptor activation is antinociceptive in sensory neurons via PI3Kgamma, AMPK and GRK2.
Title: Prostaglandin EP3 receptor activation is antinociceptive in sensory neurons via PI3Kγ, AMPK and GRK2.
E-prostanoid 3 receptor deficiency on myeloid cells protects against ischemic acute kidney injury via breaking the auto-amplification loop of necroinflammation.
Title: E-prostanoid 3 receptor deficiency on myeloid cells protects against ischemic acute kidney injury via breaking the auto-amplification loop of necroinflammation.
PGE2 -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase.
Title: PGE(2) -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase.
Synergistic Cytokine Production by ATP and PGE2 via P2X4 and EP3 Receptors in Mouse Bone-Marrow-Derived Mast Cells.
Title: Synergistic Cytokine Production by ATP and PGE(2) via P2X4 and EP(3) Receptors in Mouse Bone-Marrow-Derived Mast Cells.
Prostaglandin E1 attenuates AngII-induced cardiac hypertrophy via EP3 receptor activation and Netrin-1upregulation.
Title: Prostaglandin E1 attenuates AngII-induced cardiac hypertrophy via EP3 receptor activation and Netrin-1upregulation.
Prostaglandin EP3 receptor signaling is required to prevent insulin hypersecretion and metabolic dysfunction in a non-obese mouse model of insulin resistance.
Title: Prostaglandin EP3 receptor signaling is required to prevent insulin hypersecretion and metabolic dysfunction in a non-obese mouse model of insulin resistance.
EP3-transgenic mice, which overexpress EP3 in the cardiomyocytes, have worsened angiotensin II hypertension.
Title: The deleterious role of the prostaglandin E(2) EP(3) receptor in angiotensin II hypertension.
PGF2alpha potentiates platelet aggregation in vitro via EP3 receptor and thromboxane A2 receptor, but not PGF2a receptor
Title: Prostaglandin F2α Facilitates Platelet Activation by Acting on Prostaglandin E2 Receptor Subtype EP3 and Thromboxane A2 Receptor TP in Mice.
Data indicate that Ep3 receptor activation may be a promising therapeutic target for acute myocardial infarction (MI).
Title: Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction.

Submit: New GeneRIF Correction See all GeneRIFs (55)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234856

09.mHAa3d9.seq (e-PCR)
- UniSTS:123004

AI844685 (e-PCR)
- UniSTS:166016

Ptger3 (e-PCR), detects polymorphism
- UniSTS:144292

Ptger3 (e-PCR), detects polymorphism
- UniSTS:144293

D17406 (e-PCR)
- UniSTS:159205

D10204 (e-PCR)
- UniSTS:159206

PMC197251P3 (e-PCR)
- UniSTS:271852

PMC327192P4 (e-PCR)
- UniSTS:273138

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin E receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin E receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables prostaglandin E receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables prostaglandin E receptor activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within bicarbonate transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to forskolin	ISO Inferred from Sequence Orthology more info
involved_in desensitization of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fever generation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within fever generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in intestine smooth muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intestine smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of circadian sleep/wake cycle, wakefulness	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of forebrain neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gastric acid secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of gastrin-induced gastric acid secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of norepinephrine secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of colon smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fever generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gastric mucosal blood circulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inhibitory G protein-coupled receptor phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myofibroblast contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil extravasation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle contraction involved in micturition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of urine volume	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian sleep/wake cycle, wakefulness	ISO Inferred from Sequence Orthology more info
involved_in regulation of norepinephrine secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in urinary bladder smooth muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in proximal neuron projection	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prostaglandin E2 receptor EP3 subtype

Names: PGE receptor EP3 subtype; PGE2 receptor EP3 subtype; prostaglandin E receptor EP3 subtype; prostanoid EP3 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359745.2 → NP_001346674.1 prostaglandin E2 receptor EP3 subtype isoform 1

Status: VALIDATED

Source sequence(s)

AC132240, AC141480

Consensus CDS

CCDS89716.1

UniProtKB/Swiss-Prot

P30557

UniProtKB/TrEMBL

G3UYL9

Related

ENSMUSP00000134137.2, ENSMUST00000173533.2

Conserved Domains (2) summary

cd14964
Location:28 → 52

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:26 → 335

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_011196.4 → NP_035326.2 prostaglandin E2 receptor EP3 subtype isoform 2

See identical proteins and their annotated locations for NP_035326.2

Status: VALIDATED

Source sequence(s)

AC132240, AC141480

Consensus CDS

CCDS17932.1

UniProtKB/Swiss-Prot

P30557

UniProtKB/TrEMBL

Q6PDF2

Related

ENSMUSP00000043302.7, ENSMUST00000041175.13

Conserved Domains (1) summary

pfam00001
Location:42 → 323

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

157272459..157350392

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501140.4 → XP_006501203.1 prostaglandin E2 receptor EP3 subtype isoform X2

Conserved Domains (2) summary

cd14964
Location:27 → 53

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:26 → 278

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_011240038.3 → XP_011238340.1 prostaglandin E2 receptor EP3 subtype isoform X1

UniProtKB/Swiss-Prot

P30557

Conserved Domains (2) summary

cd14964
Location:27 → 53

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:26 → 298

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily