Ptgfr prostaglandin F receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptgfrprovided by MGI
Official Full Name: prostaglandin F receptorprovided by MGI
Primary source: MGI:MGI:97796
See related: Ensembl:ENSMUSG00000028036 AllianceGenome:MGI:97796
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: fp; PGF
Summary: Predicted to enable prostaglandin F receptor activity. Involved in positive regulation of gene expression and response to estradiol. Acts upstream of or within negative regulation of apoptotic process and response to lipopolysaccharide. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Is expressed in cloaca; genital tubercle; jaw; and viscerocranium. Orthologous to human PTGFR (prostaglandin F receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in ovary adult (RPKM 14.0), heart adult (RPKM 2.7) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 H3; 3 76.96 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (151504247..151543165, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (151798610..151837528, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PGF2alpha-FP Receptor Ameliorates Senescence of VSMCs in Vascular Remodeling by Src/PAI-1 Signal Pathway.
Title: PGF2α-FP Receptor Ameliorates Senescence of VSMCs in Vascular Remodeling by Src/PAI-1 Signal Pathway.
Contribution of FP receptors in M1 macrophage polarization via IL-10-regulated nuclear translocation of NF-kappaB p65.
Title: Contribution of FP receptors in M1 macrophage polarization via IL-10-regulated nuclear translocation of NF-κB p65.
STC-1 is a downstream effector molecule in latanoprost signaling that is independent of the F2a receptor, equivalent and non-additive in the early intraocular pressure response in wild-type mice
Title: Stanniocalcin-1 (STC-1), a downstream effector molecule in latanoprost signaling, acts independent of the FP receptor for intraocular pressure reduction.
PGF2alpha potentiates platelet aggregation in vitro via EP3 receptor and thromboxane A2 receptor, but not PGF2a receptor
Title: Prostaglandin F2α Facilitates Platelet Activation by Acting on Prostaglandin E2 Receptor Subtype EP3 and Thromboxane A2 Receptor TP in Mice.
FP receptor may have an important naive physiological role in the eye.
Title: Contribution of prostanoid FP receptor and prostaglandins in transient inflammatory ocular hypertension.
Data, including data from studies using transgenic mice, suggest that signaling via prostaglandin-F2alpha/Ptgfr and Camk2g/p38/Foxo1 MAP kinase/calcium pathways are involved in regulation of hepatic gluconeogenesis in both obesity and fasting. (Ptgfr = prostaglandin F2alpha receptor; Camk2g = calcium-calmodulin-dependent protein kinase type 2 gamma; p38 = p38 MAP kinase; Foxo1 = forkhead box transcription factor O1)
Title: Prostaglandin F(2α) Facilitates Hepatic Glucose Production Through CaMKIIγ/p38/FOXO1 Signaling Pathway in Fasting and Obesity.
Silencing of the FP receptor exerts a protective effect on diabetes-induced vascular remodeling
Title: Prostaglandin F2α receptor silencing attenuates vascular remodeling in rats with type 2 diabetes.
Prostaglandin F-receptor antagonist AS604872 exacerbates vascular inflammation in hypertensive animals, facilitating intracranial aneurysm formation and aortic dissection.
Title: Exacerbation of intracranial aneurysm and aortic dissection in hypertensive rat treated with the prostaglandin F-receptor antagonist AS604872.
Data suggest that expression of Fabp4 (fatty acid binding protein 4) in preadipocytes is up-regulated by arachidonic acid during adipogenesis; this up-regulation appears mediated by prostaglandin F2alpha/FP (prostaglandin F2alpha receptor) signaling.
Title: Arachidonic acid-dependent gene regulation during preadipocyte differentiation controls adipocyte potential.
it should be clarified as to which EP and/or FP receptor signals are physiologically essential for myometrial contraction and successful parturition.
Title: Roles of prostaglandin receptors in female reproduction.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (6) 1 citation

General gene information

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Markers

PMC170950P7 (e-PCR)
- UniSTS:271625

AI957154 (e-PCR)
- UniSTS:178954

AI059834 (e-PCR)
- UniSTS:244573

D17433 (e-PCR)
- UniSTS:159204

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin F receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin F receptor activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-mediated signaling using intracellular calcium source	ISO Inferred from Sequence Orthology more info
involved_in cellular response to prostaglandin D stimulus	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in response to estradiol	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prostaglandin F2-alpha receptor

Names: PGF receptor; PGF2-alpha receptor; prostaglandin F2alpha receptor; prostanoid FP receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.