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Oas1a 2'-5' oligoadenylate synthetase 1A [ Rattus norvegicus (Norway rat) ]

Gene ID: 192281, updated on 30-Sep-2021

Summary

Official Symbol
Oas1aprovided by RGD
Official Full Name
2'-5' oligoadenylate synthetase 1Aprovided by RGD
Primary source
RGD:621760
See related
EnsemblRapid:ENSRNOG00000001369
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Oas1; Oas1g
Summary
plays a role in interferon-induced antiviral response [RGD, Feb 2006]
Expression
Biased expression in Spleen (RPKM 97.7), Lung (RPKM 85.8) and 9 other tissues See more
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Genomic context

See Oas1a in Genome Data Viewer
Location:
12q16
Exon count:
7
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (35669798..35680505)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (41200680..41211393)

Chromosome 12 - NC_051347.1Genomic Context describing neighboring genes Neighboring gene 2 ' -5 ' oligoadenylate synthetase 1I Neighboring gene 2'-5' oligoadenylate synthetase 1D Neighboring gene 2 ' -5 ' oligoadenylate synthetase 1H Neighboring gene 2 ' -5 ' oligoadenylate synthetase 1F

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC93097

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 2'-5'-oligoadenylate synthetase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 2'-5'-oligoadenylate synthetase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 2'-5'-oligoadenylate synthetase activity IEA
Inferred from Electronic Annotation
more info
 
enables 2'-5'-oligoadenylate synthetase activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables double-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to interferon-alpha ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to interferon-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in interleukin-27-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of IP-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of chemokine (C-X-C motif) ligand 2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of viral genome replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cellular respiration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of monocyte chemotactic protein-1 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in protein complex oligomerization ISO
Inferred from Sequence Orthology
more info
 
involved_in purine nucleotide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of ribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in response to virus TAS
Traceable Author Statement
more info
PubMed 
involved_in surfactant homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in toll-like receptor 3 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in type I interferon signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in ribosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
2'-5'-oligoadenylate synthase 1A
Names
(2-5')oligo(A) synthase 1
(2-5')oligo(A) synthase 1A
(2-5')oligo(A) synthetase 1
2',5'-oligoadenylate synthetase 1, 40/46kDa
2'-5' oligoadenylate synthetase 1G
2'-5'-oligoadenylate synthase 1
2'-5'-oligoadenylate synthetase 1
2-5A synthase 1
2-5A synthase 1A
2-5A synthetase 1
25 oligoadenylate synthetase
NP_620268.2
XP_006249444.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138913.2NP_620268.2  2'-5'-oligoadenylate synthase 1A

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000228
    Related
    ENSRNOP00000040841.2, ENSRNOT00000048450.5
    Conserved Domains (2) summary
    cd05400
    Location:27167
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam10421
    Location:165349
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051347.1 Reference mRatBN7.2 Primary Assembly

    Range
    35669798..35680505
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249382.4XP_006249444.1  2'-5'-oligoadenylate synthase 1A isoform X1

    See identical proteins and their annotated locations for XP_006249444.1

    UniProtKB/TrEMBL
    Q5MYW5
    Related
    ENSRNOP00000036734.5, ENSRNOT00000038426.7
    Conserved Domains (2) summary
    cd05400
    Location:27167
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam10421
    Location:164348
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
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