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Ptp4a1 protein tyrosine phosphatase 4a1 [ Mus musculus (house mouse) ]

Gene ID: 19243, updated on 21-Apr-2024

Summary

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Official Symbol
Ptp4a1provided by MGI
Official Full Name
protein tyrosine phosphatase 4a1provided by MGI
Primary source
MGI:MGI:1277096
See related
Ensembl:ENSMUSG00000026064 Ensembl:ENSMUSG00000117310 AllianceGenome:MGI:1277096
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prl-1; C130021B01
Summary
Predicted to enable protein tyrosine phosphatase activity. Involved in positive regulation of cell migration. Predicted to be located in cytoplasmic side of plasma membrane. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; bladder wall; nervous system; olfactory epithelium; and retina. Orthologous to human PTP4A1 (protein tyrosine phosphatase 4A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 22.3), subcutaneous fat pad adult (RPKM 22.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 B; 1 11.47 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (30979384..30988838, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (30940303..30949877, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 2914 Neighboring gene PHD finger protein 3 Neighboring gene STARR-seq mESC enhancer starr_00509 Neighboring gene STARR-seq mESC enhancer starr_00510 Neighboring gene STARR-seq mESC enhancer starr_00512 Neighboring gene STARR-seq mESC enhancer starr_00514 Neighboring gene STARR-seq mESC enhancer starr_00515 Neighboring gene STARR-seq mESC enhancer starr_00516 Neighboring gene predicted gene, 53209 Neighboring gene STARR-seq mESC enhancer starr_00517 Neighboring gene Aly/REF export factor family member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Protein tyrosine phosphatase of liver regeneration-1 is required for normal timing of cell cycle progression during liver regeneration. Jiao Y, et al. Am J Physiol Gastrointest Liver Physiol, 2015 Jan 15. PMID 25377314, Free PMC Article
  2. Oxidative stress-induced expression and modulation of Phosphatase of Regenerating Liver-1 (PRL-1) in mammalian retina. Yu L, et al. Biochim Biophys Acta, 2007 Sep. PMID 17673310, Free PMC Article
  3. Role of phosphatase of regenerating liver 1 (PRL1) in spermatogenesis. Bai Y, et al. Sci Rep, 2016 Sep 26. PMID 27666520, Free PMC Article
  4. Developmental expression of the murine Prl-1 protein tyrosine phosphatase gene. Rundle CH, et al. J Exp Zool, 1999 May 1. PMID 10194868
  5. PRL-1, a unique nuclear protein tyrosine phosphatase, affects cell growth. Diamond RH, et al. Mol Cell Biol, 1994 Jun. PMID 8196618, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endothelial PTP4A1 mitigates vascular inflammation via USF1/A20 axis-mediated NF-kappaB inactivation.
    Title: Endothelial PTP4A1 mitigates vascular inflammation via USF1/A20 axis-mediated NF-κB inactivation.
  2. The adaptor SH2B1 and the phosphatase PTP4A1 regulate the phosphorylation of cytohesin-2 in myelinating Schwann cells in mice.
    Title: The adaptor SH2B1 and the phosphatase PTP4A1 regulate the phosphorylation of cytohesin-2 in myelinating Schwann cells in mice.
  3. data shed new light on the structural basis underlying the interaction between PRL phosphatases and CNNM transporters and provides a hypothesis about the molecular mechanism by which PRL-1, upon binding to CNNM2, might increase the intracellular concentration of Mg(2+) thereby contributing to tumor progression and metastasis.
    Title: Structural Basis of the Oncogenic Interaction of Phosphatase PRL-1 with the Magnesium Transporter CNNM2.
  4. Prl-1 is required for proper timing of liver regeneration after partial hepatectomy
    Title: Protein tyrosine phosphatase of liver regeneration-1 is required for normal timing of cell cycle progression during liver regeneration.
  5. PRL-1 binding to p115 RhoGAP provides a coordinated mechanism underlying ERK1/2 and RhoA activation
    Title: PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein.
  6. In cones and cone-derived cultured cells both Prl-1 activity and Prl-1 gene expression are modulated under oxidative stress.
    Title: Oxidative stress-induced expression and modulation of Phosphatase of Regenerating Liver-1 (PRL-1) in mammalian retina.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC25304, MGC102117

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables prenylated protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endosome TAS
Traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
protein tyrosine phosphatase type IVA 1
Names
protein-tyrosine phosphatase of regenerating liver 1
NP_001407715.1
NP_001407716.1
NP_001407717.1
NP_001407718.1
NP_001407719.1
NP_001407720.1
NP_035330.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420786.1 → NP_001407715.1  protein tyrosine phosphatase type IVA 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC153137
    UniProtKB/Swiss-Prot
    O09097, O09154, Q3UFU9, Q63739
    UniProtKB/TrEMBL
    B9EKL6

  2. NM_001420787.1 → NP_001407716.1  protein tyrosine phosphatase type IVA 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC153137
    UniProtKB/Swiss-Prot
    O09097, O09154, Q3UFU9, Q63739
    UniProtKB/TrEMBL
    B9EKL6

  3. NM_001420788.1 → NP_001407717.1  protein tyrosine phosphatase type IVA 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC153137
    UniProtKB/Swiss-Prot
    O09097, O09154, Q3UFU9, Q63739
    UniProtKB/TrEMBL
    B9EKL6

  4. NM_001420789.1 → NP_001407718.1  protein tyrosine phosphatase type IVA 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153137

  5. NM_001420790.1 → NP_001407719.1  protein tyrosine phosphatase type IVA 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153137

  6. NM_001420791.1 → NP_001407720.1  protein tyrosine phosphatase type IVA 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC153137

  7. NM_011200.3 → NP_035330.1  protein tyrosine phosphatase type IVA 1 isoform 1

    See identical proteins and their annotated locations for NP_035330.1

    Status: VALIDATED

    Source sequence(s)
    AC153137
    Consensus CDS
    CCDS14858.1
    UniProtKB/Swiss-Prot
    O09097, O09154, Q3UFU9, Q63739
    UniProtKB/TrEMBL
    B9EKL6
    Related
    ENSMUSP00000027232.8, ENSMUST00000027232.15
    Conserved Domains (1) summary
    cd18537
    Location:1 → 167
    PTP-IVa1; protein tyrosine phosphatase type IVA 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    30979384..30988838 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63739.1 GenPept UniProtKB/Swiss-Prot:Q63739

Gene LinkOut

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