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Ptpn14 protein tyrosine phosphatase, non-receptor type 14 [ Mus musculus (house mouse) ]

Gene ID: 19250, updated on 21-Apr-2024

Summary

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Official Symbol
Ptpn14provided by MGI
Official Full Name
protein tyrosine phosphatase, non-receptor type 14provided by MGI
Primary source
MGI:MGI:102467
See related
Ensembl:ENSMUSG00000026604 AllianceGenome:MGI:102467
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PTP36; C130080N23Rik
Summary
Predicted to enable protein tyrosine phosphatase activity; receptor tyrosine kinase binding activity; and transcription coregulator activity. Involved in lymphangiogenesis. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; musculoskeletal system; and sensory organ. Orthologous to human PTPN14 (protein tyrosine phosphatase non-receptor type 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 7.4), lung adult (RPKM 7.1) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H6; 1 95.03 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (189460417..189608892)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (189728216..189876695)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3351 Neighboring gene predicted gene, 30088 Neighboring gene centromere protein F Neighboring gene STARR-positive B cell enhancer ABC_E802 Neighboring gene STARR-positive B cell enhancer mm9_chr1:191524821-191525121 Neighboring gene STARR-seq mESC enhancer starr_03400 Neighboring gene STARR-seq mESC enhancer starr_03401 Neighboring gene STARR-seq mESC enhancer starr_03402 Neighboring gene predicted gene, 51739 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:191627745-191627946 Neighboring gene STARR-seq mESC enhancer starr_03406 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:191654884-191655189 Neighboring gene STARR-seq mESC enhancer starr_03408 Neighboring gene STARR-seq mESC enhancer starr_03409 Neighboring gene predicted gene, 30280 Neighboring gene predicted gene, 26574 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:191691042-191691151 Neighboring gene STARR-seq mESC enhancer starr_03412 Neighboring gene SET and MYND domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_03413 Neighboring gene STARR-positive B cell enhancer mm9_chr1:191796963-191797263 Neighboring gene predicted gene, 39736

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MmuPV1 E7's interaction with PTPN14 delays Epithelial differentiation and contributes to virus-induced skin disease. Romero-Masters JC, et al. PLoS Pathog, 2023 Apr. PMID 37036883, Free PMC Article
  2. The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking. Belle L, et al. Sci Signal, 2015 Feb 17. PMID 25690013
  3. Characterization of newly identified four isoforms for a putative cytosolic protein tyrosine phosphatase PTP36. Aoyama K, et al. Biochem Biophys Res Commun, 1999 Dec 20. PMID 10600535
  4. cDNA cloning of a novel protein tyrosine phosphatase with homology to cytoskeletal protein 4.1 and its expression in T-lineage cells. Sawada M, et al. Biochem Biophys Res Commun, 1994 Aug 30. PMID 8074693
  5. PTPN14 deficiency alleviates podocyte injury through suppressing inflammation and fibrosis by targeting TRIP6 in diabetic nephropathy. Lin Y, et al. Biochem Biophys Res Commun, 2021 Apr 23. PMID 33684622

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MmuPV1 E7's interaction with PTPN14 delays Epithelial differentiation and contributes to virus-induced skin disease.
    Title: MmuPV1 E7's interaction with PTPN14 delays Epithelial differentiation and contributes to virus-induced skin disease.
  2. PTPN14 deficiency alleviates podocyte injury through suppressing inflammation and fibrosis by targeting TRIP6 in diabetic nephropathy.
    Title: PTPN14 deficiency alleviates podocyte injury through suppressing inflammation and fibrosis by targeting TRIP6 in diabetic nephropathy.
  3. PTPN14 aggravates inflammation through promoting proteasomal degradation of SOCS7 in acute liver failure.
    Title: PTPN14 aggravates inflammation through promoting proteasomal degradation of SOCS7 in acute liver failure.
  4. Phospholipase D2 restores endothelial barrier function by promoting PTPN14-mediated VE-cadherin dephosphorylation.
    Title: Phospholipase D2 restores endothelial barrier function by promoting PTPN14-mediated VE-cadherin dephosphorylation.
  5. The non-receptor tyrosine phosphatase type 14 blocks caveolin-1-enhanced cancer cell metastasis.
    Title: The non-receptor tyrosine phosphatase type 14 blocks caveolin-1-enhanced cancer cell metastasis.
  6. The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking.
    Title: The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking.
  7. PTPN14 has a role in angiogenesis and/or arteriovenous fate, acting via EphrinB2 and ACVRL1/activin receptor-like kinase 1
    Title: Mouse and human strategies identify PTPN14 as a modifier of angiogenesis and hereditary haemorrhagic telangiectasia.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (2) 
  • Endonuclease-mediated (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in lymphangiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lymphangiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lymphangiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 14
Names
protein-tyrosine phosphatase PTP36
NP_033002.2
XP_006497192.1
XP_006497194.1
XP_006497196.1
XP_006497197.1
XP_030108157.1
XP_036018685.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008976.2 → NP_033002.2  tyrosine-protein phosphatase non-receptor type 14

    See identical proteins and their annotated locations for NP_033002.2

    Status: VALIDATED

    Source sequence(s)
    AC140250, AC140461, AK037646, AK136544, BB663191, CK780322, DV552967
    Consensus CDS
    CCDS15609.1
    UniProtKB/Swiss-Prot
    G5E8M1, Q62130
    UniProtKB/TrEMBL
    Q8CAV9
    Related
    ENSMUSP00000095051.3, ENSMUST00000097442.9
    Conserved Domains (3) summary
    smart00295
    Location:24 → 220
    B41; Band 4.1 homologues
    cd13188
    Location:215 → 305
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
    cd14599
    Location:898 → 1184
    PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    189460417..189608892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497134.4 → XP_006497197.1  tyrosine-protein phosphatase non-receptor type 14 isoform X2

    Conserved Domains (3) summary
    cd13188
    Location:116 → 206
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
    cd14599
    Location:799 → 1085
    PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14
    pfam00373
    Location:6 → 121
    FERM_M; FERM central domain

  2. XM_036162792.1 → XP_036018685.1  tyrosine-protein phosphatase non-receptor type 14 isoform X1

    UniProtKB/Swiss-Prot
    G5E8M1, Q62130
    UniProtKB/TrEMBL
    Q8CAV9
    Conserved Domains (3) summary
    smart00295
    Location:24 → 220
    B41; Band 4.1 homologues
    cd13188
    Location:215 → 305
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
    cd14599
    Location:898 → 1184
    PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14

  3. XM_006497131.5 → XP_006497194.1  tyrosine-protein phosphatase non-receptor type 14 isoform X1

    See identical proteins and their annotated locations for XP_006497194.1

    UniProtKB/Swiss-Prot
    G5E8M1, Q62130
    UniProtKB/TrEMBL
    Q8CAV9
    Conserved Domains (3) summary
    smart00295
    Location:24 → 220
    B41; Band 4.1 homologues
    cd13188
    Location:215 → 305
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
    cd14599
    Location:898 → 1184
    PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14

  4. XM_030252297.2 → XP_030108157.1  tyrosine-protein phosphatase non-receptor type 14 isoform X1

    UniProtKB/Swiss-Prot
    G5E8M1, Q62130
    UniProtKB/TrEMBL
    Q8CAV9
    Conserved Domains (3) summary
    smart00295
    Location:24 → 220
    B41; Band 4.1 homologues
    cd13188
    Location:215 → 305
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
    cd14599
    Location:898 → 1184
    PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14

  5. XM_006497129.5 → XP_006497192.1  tyrosine-protein phosphatase non-receptor type 14 isoform X1

    See identical proteins and their annotated locations for XP_006497192.1

    UniProtKB/Swiss-Prot
    G5E8M1, Q62130
    UniProtKB/TrEMBL
    Q8CAV9
    Conserved Domains (3) summary
    smart00295
    Location:24 → 220
    B41; Band 4.1 homologues
    cd13188
    Location:215 → 305
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
    cd14599
    Location:898 → 1184
    PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14

  6. XM_006497133.5 → XP_006497196.1  tyrosine-protein phosphatase non-receptor type 14 isoform X1

    See identical proteins and their annotated locations for XP_006497196.1

    UniProtKB/Swiss-Prot
    G5E8M1, Q62130
    UniProtKB/TrEMBL
    Q8CAV9
    Conserved Domains (3) summary
    smart00295
    Location:24 → 220
    B41; Band 4.1 homologues
    cd13188
    Location:215 → 305
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
    cd14599
    Location:898 → 1184
    PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033287.1: Suppressed sequence

    Description
    NM_001033287.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62130.2 GenPept UniProtKB/Swiss-Prot:Q62130

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