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Dusp1 dual specificity phosphatase 1 [ Mus musculus (house mouse) ]

Gene ID: 19252, updated on 2-Oct-2021

Summary

Official Symbol
Dusp1provided by MGI
Official Full Name
dual specificity phosphatase 1provided by MGI
Primary source
MGI:MGI:105120
See related
Ensembl:ENSMUSG00000024190
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MKP; Ptp; erp; MKP1; mkp-; mkp-1; 3CH134; Ptpn16; U19515
Expression
Ubiquitous expression in lung adult (RPKM 117.9), heart adult (RPKM 43.4) and 28 other tissues See more
Orthologs
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Genomic context

See Dusp1 in Genome Data Viewer
Location:
17 A3.3; 17 13.28 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26724565..26727446, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26505591..26508472, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (26642536..26645417, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene neuralized E3 ubiquitin protein ligase 1B Neighboring gene predicted gene, 34455 Neighboring gene RIKEN cDNA 1700049J03 gene Neighboring gene predicted gene, 34606 Neighboring gene ribosomal protein S2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MAP kinase tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MAP kinase tyrosine/serine/threonine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables mitogen-activated protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mitogen-activated protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine/serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein tyrosine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to chemokine ISO
Inferred from Sequence Orthology
more info
 
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in endoderm formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of p38MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-threonine dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-tyrosine dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-tyrosine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dual specificity protein phosphatase 1
Names
MAP kinase phosphatase 1
mitogen-activated protein kinase phosphatase-1
protein tyrosine phosphatase, non-receptor type 16
protein-tyrosine phosphatase 3CH134
protein-tyrosine phosphatase ERP
NP_038670.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013642.3NP_038670.1  dual specificity protein phosphatase 1

    See identical proteins and their annotated locations for NP_038670.1

    Status: VALIDATED

    Source sequence(s)
    AK159251, U19515
    Consensus CDS
    CCDS28552.1
    UniProtKB/Swiss-Prot
    P28563
    UniProtKB/TrEMBL
    Q3U8K3
    Related
    ENSMUSP00000025025.7, ENSMUST00000025025.7
    Conserved Domains (3) summary
    COG2453
    Location:188313
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    cd00127
    Location:173309
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:7136
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    26724565..26727446 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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