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Pla2g15 phospholipase A2, group XV [ Mus musculus (house mouse) ]

Gene ID: 192654, updated on 23-Jun-2021

Summary

Official Symbol
Pla2g15provided by MGI
Official Full Name
phospholipase A2, group XVprovided by MGI
Primary source
MGI:MGI:2178076
See related
Ensembl:ENSMUSG00000031903
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
L; Ly; ACS; LLPL; Lpla2; C87498; Lypla3
Expression
Ubiquitous expression in spleen adult (RPKM 14.2), subcutaneous fat pad adult (RPKM 13.0) and 28 other tissues See more
Orthologs
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Genomic context

See Pla2g15 in Genome Data Viewer
Location:
8; 8 D3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106876986..106891350)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (106150354..106164718)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (108674299..108688615)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 Neighboring gene RIKEN cDNA 1810019D21 gene Neighboring gene epithelial splicing regulatory protein 2 Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 Neighboring gene solute carrier family 7, member 6 opposite strand

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-acyl-2-lysophosphatidylserine acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables O-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables acylglycerol O-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium-independent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-independent phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-independent phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
NOT enables lysophospholipase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidyl phospholipase B activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylserine 1-acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase A1 activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipase A1 activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ceramide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within ceramide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ceramide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ceramide metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in diacylglycerol biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glycerophospholipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glycerophospholipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylcholine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylcholine catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylcholine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylcholine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylethanolamine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylethanolamine catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylglycerol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylserine metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phospholipase A2 group XV
Names
1-O-acylceramide synthase
LCAT-like lysophospholipase
group XV phospholipase A2
lysophospholipase 3
lysosomal phospholipase A and acyltransferase
lysosomal phospholipase A2
NP_001344248.1
NP_598553.1
XP_036009728.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357319.1NP_001344248.1  phospholipase A2 group XV isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC133195, AK028614, BM226964
    Consensus CDS
    CCDS90455.1
    Related
    ENSMUSP00000148565.2, ENSMUST00000212963.2
    Conserved Domains (1) summary
    cl21494
    Location:84167
    Abhydrolase; alpha/beta hydrolases
  2. NM_133792.3NP_598553.1  phospholipase A2 group XV isoform 1 precursor

    See identical proteins and their annotated locations for NP_598553.1

    Status: VALIDATED

    Source sequence(s)
    AC133195, AK085194, BM226964
    Consensus CDS
    CCDS22630.1
    UniProtKB/Swiss-Prot
    Q8VEB4
    Related
    ENSMUSP00000034377.7, ENSMUST00000034377.8
    Conserved Domains (1) summary
    cl21494
    Location:84396
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106876986..106891350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153835.1XP_036009728.1  phospholipase A2 group XV isoform X1

    Conserved Domains (1) summary
    cl21494
    Location:45357
    Abhydrolase; alpha/beta hydrolases
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