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Pvalb parvalbumin [ Mus musculus (house mouse) ]

Gene ID: 19293, updated on 16-Apr-2024

Summary

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Official Symbol
Pvalbprovided by MGI
Official Full Name
parvalbuminprovided by MGI
Primary source
MGI:MGI:97821
See related
Ensembl:ENSMUSG00000005716 AllianceGenome:MGI:97821
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PV; Pva; Parv
Summary
Predicted to enable calcium ion binding activity and identical protein binding activity. Involved in excitatory chemical synaptic transmission; gene expression; and inhibitory chemical synaptic transmission. Located in axon and cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; nervous system; and sensory organ. Orthologous to human PVALB (parvalbumin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 192.6), mammary gland adult (RPKM 147.4) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Pvalb in Genome Data Viewer
Location:
15 E1; 15 36.93 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78075312..78090600, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78191112..78206400, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, gamma subunit 2 Neighboring gene RIKEN cDNA A730060N03 gene Neighboring gene STARR-positive B cell enhancer mm9_chr15:77950201-77950501 Neighboring gene STARR-positive B cell enhancer ABC_E4137 Neighboring gene STARR-positive B cell enhancer ABC_E4138 Neighboring gene intraflagellar transport 27 Neighboring gene STARR-seq mESC enhancer starr_39140 Neighboring gene STARR-seq mESC enhancer starr_39141 Neighboring gene STARR-positive B cell enhancer ABC_E2443 Neighboring gene STARR-positive B cell enhancer ABC_E9914 Neighboring gene neutrophil cytosolic factor 4 Neighboring gene microRNA 7676-1 Neighboring gene colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fast-Spiking Interneurons of the Premotor Cortex Contribute to Initiation and Execution of Spontaneous Actions. Giordano N, et al. J Neurosci, 2023 Jun 7. PMID 37197980, Free PMC Article
  2. A shift in the mechanisms controlling hippocampal engram formation during brain maturation. Ramsaran AI, et al. Science, 2023 May 5. PMID 37141366
  3. HCN channels at the cell soma ensure the rapid electrical reactivity of fast-spiking interneurons in human neocortex. Szegedi V, et al. PLoS Biol, 2023 Feb. PMID 36745683, Free PMC Article
  4. Optogenetic Low-Frequency Stimulation of Principal Neurons, but Not Parvalbumin-Positive Interneurons, Prevents Generation of Ictal Discharges in Rodent Entorhinal Cortex in an In Vitro 4-Aminopyridine Model. Proskurina EY, et al. Int J Mol Sci, 2022 Dec 22. PMID 36613660, Free PMC Article
  5. Reduced inhibitory and excitatory input onto parvalbumin interneurons mediated by perineuronal net might contribute to cognitive impairments in a mouse model of sepsis-associated encephalopathy. Zhang L, et al. Neuropharmacology, 2023 Mar 1. PMID 36543316

See all (1393) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Parvalbumin and Somatostatin: Biomarkers for Two Parallel Tectothalamic Pathways in the Auditory Midbrain.
    Title: Parvalbumin and Somatostatin: Biomarkers for Two Parallel Tectothalamic Pathways in the Auditory Midbrain.
  2. Parvalbumin interneurons dysfunction is potentially associated with FalphaMNs decrease and NRG1-ErbB4 signaling inhibition in spinal cord in amyotrophic lateral sclerosis.
    Title: Parvalbumin interneurons dysfunction is potentially associated with FαMNs decrease and NRG1-ErbB4 signaling inhibition in spinal cord in amyotrophic lateral sclerosis.
  3. Prefrontal and Hippocampal Parvalbumin Interneurons in Animal Models for Schizophrenia: A Systematic Review and Meta-analysis.
    Title: Prefrontal and Hippocampal Parvalbumin Interneurons in Animal Models for Schizophrenia: A Systematic Review and Meta-analysis.
  4. Velocity of conduction between columns and layers in barrel cortex reported by parvalbumin interneurons.
    Title: Velocity of conduction between columns and layers in barrel cortex reported by parvalbumin interneurons.
  5. Deletions of Cacna2d3 in parvalbumin-expressing neurons leads to autistic-like phenotypes in mice.
    Title: Deletions of Cacna2d3 in parvalbumin-expressing neurons leads to autistic-like phenotypes in mice.
  6. Circadian time- and sleep-dependent modulation of cortical parvalbumin-positive inhibitory neurons.
    Title: Circadian time- and sleep-dependent modulation of cortical parvalbumin-positive inhibitory neurons.
  7. Reduced inhibitory and excitatory input onto parvalbumin interneurons mediated by perineuronal net might contribute to cognitive impairments in a mouse model of sepsis-associated encephalopathy.
    Title: Reduced inhibitory and excitatory input onto parvalbumin interneurons mediated by perineuronal net might contribute to cognitive impairments in a mouse model of sepsis-associated encephalopathy.
  8. NMDA receptor hypofunction underlies deficits in parvalbumin interneurons and social behavior in neuroligin 3 R451C knockin mice.
    Title: NMDA receptor hypofunction underlies deficits in parvalbumin interneurons and social behavior in neuroligin 3 R451C knockin mice.
  9. Genetic targeting of adult Renshaw cells using a Calbindin 1 destabilized Cre allele for intersection with Parvalbumin or Engrailed1.
    Title: Genetic targeting of adult Renshaw cells using a Calbindin 1 destabilized Cre allele for intersection with Parvalbumin or Engrailed1.
  10. Postnatal Sox6 Regulates Synaptic Function of Cortical Parvalbumin-Expressing Neurons.
    Title: Postnatal Sox6 Regulates Synaptic Function of Cortical Parvalbumin-Expressing Neurons.
Submit: New GeneRIF Correction See all GeneRIFs (87)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (16)  1 citation
  • Endonuclease-mediated (5) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in excitatory chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inhibitory chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cuticular plate ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in stereocilium ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
parvalbumin alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330686.1 → NP_001317615.1  parvalbumin alpha

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI645659, AK131986, DV051867
    Consensus CDS
    CCDS27609.1
    UniProtKB/Swiss-Prot
    P32848
    UniProtKB/TrEMBL
    Q545M7
    Related
    ENSMUSP00000005860.10, ENSMUST00000005860.16
    Conserved Domains (1) summary
    cd16254
    Location:9 → 109
    EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

  2. NM_013645.4 → NP_038673.2  parvalbumin alpha

    See identical proteins and their annotated locations for NP_038673.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA467036, AI645659, AL589692, CK622340, DV051867
    Consensus CDS
    CCDS27609.1
    UniProtKB/Swiss-Prot
    P32848
    UniProtKB/TrEMBL
    Q545M7
    Related
    ENSMUSP00000112598.2, ENSMUST00000120592.2
    Conserved Domains (1) summary
    cd16254
    Location:9 → 109
    EFh_parvalbumin_alpha; EF-hand, calcium binding motif, found in alpha-parvalbumin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    78075312..78090600 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32848.3 GenPept UniProtKB/Swiss-Prot:P32848

Gene LinkOut

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