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Rad51ap1 RAD51 associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 19362, updated on 5-Mar-2024

Summary

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Official Symbol
Rad51ap1provided by MGI
Official Full Name
RAD51 associated protein 1provided by MGI
Primary source
MGI:MGI:1098224
See related
Ensembl:ENSMUSG00000030346 AllianceGenome:MGI:1098224
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RAB22; 2510006L10Rik
Summary
Predicted to enable nucleic acid binding activity. Acts upstream of or within DNA recombination. Located in chromosome and nucleus. Is expressed in several structures, including brain ventricular layer; early conceptus; gut; reproductive system; and trachea. Orthologous to human RAD51AP1 (RAD51 associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 17.5), liver E14.5 (RPKM 14.3) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 F3; 6 61.92 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (126900378..126916664, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (126923415..126939621, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene A kinase anchor protein 3 Neighboring gene dual-specificity tyrosine phosphorylation regulated kinase 4 Neighboring gene STARR-positive B cell enhancer ABC_E688 Neighboring gene STARR-positive B cell enhancer ABC_E6491 Neighboring gene metaxin 1 pseudogene Neighboring gene DNA segment, Chr 6, Wayne State University 163, expressed Neighboring gene STARR-positive B cell enhancer ABC_E8131 Neighboring gene predicted gene 43124

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RAD51AP1 Deficiency Reduces Tumor Growth by Targeting Stem Cell Self-Renewal. Bridges AE, et al. Cancer Res, 2020 Sep 15. PMID 32665355, Free PMC Article
  2. VipD of Legionella pneumophila targets activated Rab5 and Rab22 to interfere with endosomal trafficking in macrophages. Ku B, et al. PLoS Pathog, 2012. PMID 23271971, Free PMC Article
  3. RAD51AP1 Loss Attenuates Colorectal Cancer Stem Cell Renewal and Sensitizes to Chemotherapy. Bridges AE, et al. Mol Cancer Res, 2021 Sep. PMID 34099522, Free PMC Article
  4. Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1). Dray E, et al. Proc Natl Acad Sci U S A, 2011 Mar 1. PMID 21307306, Free PMC Article
  5. Transcript profiling during preimplantation mouse development. Zeng F, et al. Dev Biol, 2004 Aug 15. PMID 15282163

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The gene RAD51AP1 promotes the progression of pancreatic cancer via the PI3K/Akt/NF-kappaB signaling pathway.
    Title: The gene RAD51AP1 promotes the progression of pancreatic cancer via the PI3K/Akt/NF-κB signaling pathway.
  2. RAD51AP1 Loss Attenuates Colorectal Cancer Stem Cell Renewal and Sensitizes to Chemotherapy.
    Title: RAD51AP1 Loss Attenuates Colorectal Cancer Stem Cell Renewal and Sensitizes to Chemotherapy.
  3. RAD51AP1 Deficiency Reduces Tumor Growth by Targeting Stem Cell Self-Renewal.
    Title: RAD51AP1 Deficiency Reduces Tumor Growth by Targeting Stem Cell Self-Renewal.
  4. VipD of Legionella pneumophila targets activated Rab5 and Rab22 to interfere with endosomal trafficking in macrophages.
    Title: VipD of Legionella pneumophila targets activated Rab5 and Rab22 to interfere with endosomal trafficking in macrophages.
  5. RAD51AP1 foci colocalize with a subset of DMC1 foci in spermatocytes.
    Title: Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1).
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-loop DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA secondary structure binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within DNA recombination IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in interstrand cross-link repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interstrand cross-link repair ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of reciprocal meiotic recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RAD51-associated protein 1
Names
RAD51-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347455.1 → NP_001334384.1  RAD51-associated protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1
    Source sequence(s)
    AK077829, AK079525, AW457762, BB620338
    Consensus CDS
    CCDS85161.1
    UniProtKB/Swiss-Prot
    O55219, Q8BP36, Q8C551, Q99L94, Q9D0J0
    UniProtKB/TrEMBL
    A0A0R4J1H1
    Related
    ENSMUSP00000107839.2, ENSMUST00000112220.8

  2. NM_009013.4 → NP_033039.2  RAD51-associated protein 1 isoform 1

    See identical proteins and their annotated locations for NP_033039.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK077829, AK079525, AW457762, BB620338
    Consensus CDS
    CCDS39644.1
    UniProtKB/Swiss-Prot
    O55219, Q8BP36, Q8C551, Q99L94, Q9D0J0
    UniProtKB/TrEMBL
    A0A0R4J1G4
    Related
    ENSMUSP00000107841.2, ENSMUST00000112221.8
    Conserved Domains (2) summary
    pfam10486
    Location:126 → 268
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
    pfam15696
    Location:293 → 331
    RAD51_interact; RAD51 interacting motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    126900378..126916664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255239.1 → XP_030111099.1  RAD51-associated protein 1 isoform X1

    Conserved Domains (2) summary
    pfam10500
    Location:46 → 148
    SR-25; Nuclear RNA-splicing-associated protein
    pfam15696
    Location:193 → 231
    RAD51_interact; RAD51 interacting motif

  2. XM_030255240.1 → XP_030111100.1  RAD51-associated protein 1 isoform X1

    Conserved Domains (2) summary
    pfam10500
    Location:46 → 148
    SR-25; Nuclear RNA-splicing-associated protein
    pfam15696
    Location:193 → 231
    RAD51_interact; RAD51 interacting motif

RNA

  1. XR_004942924.1 RNA Sequence

  2. XR_377433.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C551.2 GenPept UniProtKB/Swiss-Prot:Q8C551

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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