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Rbmx RNA binding motif protein, X chromosome [ Mus musculus (house mouse) ]

Gene ID: 19655, updated on 21-Apr-2024

Summary

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Official Symbol
Rbmxprovided by MGI
Official Full Name
RNA binding motif protein, X chromosomeprovided by MGI
Primary source
MGI:MGI:1343044
See related
Ensembl:ENSMUSG00000031134 AllianceGenome:MGI:1343044
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
hnRNP G
Summary
Predicted to enable several functions, including chromatin binding activity; identical protein binding activity; and nucleic acid binding activity. Predicted to be involved in several processes, including RNA metabolic process; cellular response to interleukin-1; and regulation of RNA metabolic process. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in euchromatin; extracellular exosome; and nucleus. Predicted to be part of catalytic step 2 spliceosome and supraspliceosomal complex. Is expressed in several structures, including central nervous system; female reproductive system; gut; sensory organ; and thymus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Shashi type. Orthologous to human RBMX (RNA binding motif protein X-linked). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E14 (RPKM 55.1), CNS E11.5 (RPKM 51.1) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X A6; X 31.64 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (56428708..56438405, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (57383348..57393046, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene CD40 ligand Neighboring gene Rac/Cdc42 guanine nucleotide exchange factor 6 Neighboring gene STARR-positive B cell enhancer ABC_E7690 Neighboring gene STARR-seq mESC enhancer starr_47212 Neighboring gene STARR-positive B cell enhancer ABC_E7691 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:54563182-54563369 Neighboring gene STARR-seq mESC enhancer starr_47213 Neighboring gene STARR-seq mESC enhancer starr_47214 Neighboring gene small nucleolar RNA, C/D box 61 Neighboring gene transmembrane 9 superfamily member 5 Neighboring gene G protein-coupled receptor 101

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcriptional control of CBX5 by the RNA binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia. Prieto C, et al. Nat Cancer, 2021 Jul. PMID 34458856, Free PMC Article
  2. RBMY evolved on the Y chromosome from a ubiquitously transcribed X-Y identical gene. Mazeyrat S, et al. Nat Genet, 1999 Jul. PMID 10391207
  3. RBMX is a novel hepatic transcriptional regulator of SREBP-1c gene response to high-fructose diet. Takemoto T, et al. FEBS Lett, 2007 Jan 23. PMID 17188681
  4. SAFB1, an RBMX-binding protein, is a newly identified regulator of hepatic SREBP-1c gene. Omura Y, et al. BMB Rep, 2009 Apr 30. PMID 19403048
  5. Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome. Sandstedt SA, et al. Genome Res, 2004 Feb. PMID 14762062, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results indicate a major role for SAFB1 in the activation of Srebp-1c through its interaction with RBMX.
    Title: SAFB1, an RBMX-binding protein, is a newly identified regulator of hepatic SREBP-1c gene.
  2. RBMX may control SREBP-1c expression in mouse liver in response to high-fructose diet.
    Title: RBMX is a novel hepatic transcriptional regulator of SREBP-1c gene response to high-fructose diet.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splice site recognition ISO
Inferred from Sequence Orthology
more info
  
involved_in membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynapse organization ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of euchromatin ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of supraspliceosomal complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RNA-binding motif protein, X chromosome
Names
heterogeneous nuclear ribonucleoprotein G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166623.2 → NP_001160095.1  RNA-binding motif protein, X chromosome

    See identical proteins and their annotated locations for NP_001160095.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses a different splice site in the 5' UTR versus variant 1. Variants 1, 3, 4, and 5 all encode the same protein.
    Source sequence(s)
    AL672106
    Consensus CDS
    CCDS30153.1
    UniProtKB/Swiss-Prot
    Q8C2U6, Q9R0Y0, Q9WV02
    UniProtKB/TrEMBL
    A0A2I3BRL8
    Related
    ENSMUSP00000110374.2, ENSMUST00000114726.8
    Conserved Domains (3) summary
    PRK14086
    Location:167 → 306
    dnaA; chromosomal replication initiator protein DnaA
    pfam08081
    Location:173 → 217
    RBM1CTR; RBM1CTR (NUC064) family
    cd12382
    Location:7 → 86
    RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins

  2. NM_001425953.1 → NP_001412882.1  RNA-binding motif protein, X chromosome

    Status: VALIDATED

    Source sequence(s)
    AL672106
    UniProtKB/Swiss-Prot
    Q8C2U6, Q9R0Y0, Q9WV02

  3. NM_001425954.1 → NP_001412883.1  RNA-binding motif protein, X chromosome

    Status: VALIDATED

    Source sequence(s)
    AL672106
    UniProtKB/Swiss-Prot
    Q8C2U6, Q9R0Y0, Q9WV02

  4. NM_011252.5 → NP_035382.1  RNA-binding motif protein, X chromosome

    See identical proteins and their annotated locations for NP_035382.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the more frequently occurring transcript. Variants 1, 3, 4, and 5 all encode the same protein.
    Source sequence(s)
    AL672106
    Consensus CDS
    CCDS30153.1
    UniProtKB/Swiss-Prot
    Q8C2U6, Q9R0Y0, Q9WV02
    UniProtKB/TrEMBL
    A0A2I3BRL8
    Related
    ENSMUSP00000110378.2, ENSMUST00000114730.8
    Conserved Domains (3) summary
    PRK14086
    Location:167 → 306
    dnaA; chromosomal replication initiator protein DnaA
    pfam08081
    Location:173 → 217
    RBM1CTR; RBM1CTR (NUC064) family
    cd12382
    Location:7 → 86
    RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins

RNA

  1. NR_029425.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has alternate 3' sequence, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay (NMD) candidate, probably not making a protein.
    Source sequence(s)
    AL672106

  2. NR_189635.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL672106

  3. NR_189636.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL672106

  4. NR_189637.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL672106

  5. NR_189638.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL672106

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    56428708..56438405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161864.1 → XP_036017757.1  RNA-binding motif protein, X chromosome isoform X1

    UniProtKB/Swiss-Prot
    Q8C2U6, Q9R0Y0, Q9WV02
    UniProtKB/TrEMBL
    A0A2I3BRL8
    Conserved Domains (3) summary
    PRK14086
    Location:167 → 306
    dnaA; chromosomal replication initiator protein DnaA
    pfam08081
    Location:173 → 217
    RBM1CTR; RBM1CTR (NUC064) family
    cd12382
    Location:7 → 86
    RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins

  2. XM_036161865.1 → XP_036017758.1  RNA-binding motif protein, X chromosome isoform X1

    UniProtKB/Swiss-Prot
    Q8C2U6, Q9R0Y0, Q9WV02
    UniProtKB/TrEMBL
    A0A2I3BRL8
    Conserved Domains (3) summary
    PRK14086
    Location:167 → 306
    dnaA; chromosomal replication initiator protein DnaA
    pfam08081
    Location:173 → 217
    RBM1CTR; RBM1CTR (NUC064) family
    cd12382
    Location:7 → 86
    RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WV02.1 GenPept UniProtKB/Swiss-Prot:Q9WV02

Gene LinkOut

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