Rbp4 retinol binding protein 4, plasma [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rbp4provided by MGI
Official Full Name: retinol binding protein 4, plasmaprovided by MGI
Primary source: MGI:MGI:97879
See related: Ensembl:ENSMUSG00000024990 AllianceGenome:MGI:97879
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rbp-4
Summary: Enables retinol binding activity. Involved in several processes, including animal organ development; gluconeogenesis; and negative regulation of cardiac muscle cell proliferation. Acts upstream of or within several processes, including detection of light stimulus involved in visual perception; retinoid metabolic process; and terpenoid transport. Located in extracellular space. Is expressed in several structures, including adipose tissue; brain; genitourinary system; gut; and hindlimb. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human RBP4 (retinol binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 1256.0), liver E18 (RPKM 733.2) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C2; 19 32.75 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (38105068..38113769, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (38116620..38125321, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Products of the visual cycle are detected in mice lacking retinol binding protein 4, the only known vitamin A carrier in plasma.
Title: Products of the visual cycle are detected in mice lacking retinol binding protein 4, the only known vitamin A carrier in plasma.
Exosomal RBP4 potentiated hepatic lipid accumulation and inflammation in high-fat-diet-fed mice by promoting M1 polarization of Kupffer cells.
Title: Exosomal RBP4 potentiated hepatic lipid accumulation and inflammation in high-fat-diet-fed mice by promoting M1 polarization of Kupffer cells.
Elevated retinal retinol-binding protein 4 levels in diabetic mice can induce retinal neurodegeneration through microglia.
Title: Elevated retinal retinol-binding protein 4 levels in diabetic mice can induce retinal neurodegeneration through microglia.
Acute retinol mobilization by retinol-binding protein 4 in mouse liver induces fibroblast growth factor 21 expression.
Title: Acute retinol mobilization by retinol-binding protein 4 in mouse liver induces fibroblast growth factor 21 expression.
Altering retinol binding protein 4 levels in hepatitis C: Inflammation and steatosis matter.
Title: Altering retinol binding protein 4 levels in hepatitis C: Inflammation and steatosis matter.
Retinol-Binding Protein 4 Activates STRA6, Provoking Pancreatic beta-Cell Dysfunction in Type 2 Diabetes.
Title: Retinol-Binding Protein 4 Activates STRA6, Provoking Pancreatic β-Cell Dysfunction in Type 2 Diabetes.
Retinol binding protein 4 primes the NLRP3 inflammasome by signaling through Toll-like receptors 2 and 4.
Title: Retinol binding protein 4 primes the NLRP3 inflammasome by signaling through Toll-like receptors 2 and 4.
Disruption of retinoid homeostasis induces RBP4 overproduction in diabetes: O-GlcNAcylation involved.
Title: Disruption of retinoid homeostasis induces RBP4 overproduction in diabetes: O-GlcNAcylation involved.
Also during a high-fat diet challenge, elevated levels of RBP4 in the circulation failed to aggravate the worsening of systemic parameters of glucose and energy homeostasis. These findings show that liver-secreted RBP4 does not impair glucose homeostasis. We conclude that a modest increase of its circulating levels in mice, as observed in the obese, insulin-resistant state, is unlikely to be a causative factor for impaire
Title: Liver-secreted RBP4 does not impair glucose homeostasis in mice.
RBP4 is involved in all-trans retinoic acid-induced cleft palate.
Title: Involvement of RBP4 in all‑trans retinoic acid induced cleft palate.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94744 (e-PCR)
- UniSTS:119991

RBP4 (e-PCR)
- UniSTS:253880

Rbp4 (e-PCR), detects polymorphism
- UniSTS:525508

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables retinal binding	IEA Inferred from Electronic Annotation more info
enables retinoid binding	IEA Inferred from Electronic Annotation more info
enables retinol binding	IBA Inferred from Biological aspect of Ancestor more info
enables retinol binding	IDA Inferred from Direct Assay more info	PubMed
enables retinol binding	ISO Inferred from Sequence Orthology more info
enables retinol transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cardiac muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of light stimulus involved in visual perception	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic retina morphogenesis in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye development	ISO Inferred from Sequence Orthology more info
involved_in female genitalia morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart trabecula formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lung development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of gastrointestinal epithelium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of immunoglobulin production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to insulin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to retinoic acid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinal metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinol metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in retinol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinol transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retinol transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within retinol transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinol transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in urinary bladder development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in uterus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vagina development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vitamin A import into cell	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: retinol-binding protein 4

Names: PRBP; RBP; plasma retinol-binding protein; retinol binding protein 4, cellular

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159487.1 → NP_001152959.1 retinol-binding protein 4 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC101774, AK008765, AW113115, BY769772

Consensus CDS

CCDS50430.1

UniProtKB/TrEMBL

H7BWY6

Related

ENSMUSP00000025951.7, ENSMUST00000025951.14

Conserved Domains (1) summary

cd00743
Location:66 → 236

lipocalin_RBP_like; retinol-binding protein 4 and similar proteins
NM_011255.3 → NP_035385.1 retinol-binding protein 4 isoform 2 precursor

See identical proteins and their annotated locations for NP_035385.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.

Source sequence(s)

AK008765, AW113115, BY112174

Consensus CDS

CCDS29784.1

UniProtKB/Swiss-Prot

P70357, Q00724, Q566I5

UniProtKB/TrEMBL

Q3TF08

Related

ENSMUSP00000107954.3, ENSMUST00000112335.4

Conserved Domains (1) summary

cd00743
Location:22 → 192

lipocalin_RBP_like; retinol-binding protein 4 and similar proteins