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Recql RecQ protein-like [ Mus musculus (house mouse) ]

Gene ID: 19691, updated on 8-Jul-2021

Summary

Official Symbol
Recqlprovided by MGI
Official Full Name
RecQ protein-likeprovided by MGI
Primary source
MGI:MGI:103021
See related
Ensembl:ENSMUSG00000030243
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RecQ; RecQ1
Expression
Ubiquitous expression in CNS E11.5 (RPKM 4.8), CNS E14 (RPKM 3.9) and 28 other tissues See more
Orthologs
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Genomic context

See Recql in Genome Data Viewer
Location:
6 G2; 6 73.91 cM
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (142296068..142332826, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (142350342..142387100, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (142310420..142335607, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene solute carrier organic anion transporter family, member 1a5 Neighboring gene islet amyloid polypeptide Neighboring gene 60S ribosomal protein L18 pseudogene Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 1 Neighboring gene golgi transport 1B Neighboring gene spexin hormone

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent DNA/DNA annealing activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP-dependent DNA/DNA annealing activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables four-way junction helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA duplex unwinding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ATP-dependent DNA helicase Q1
Names
DNA-dependent ATPase Q1
recQ protein-like 1
NP_001191835.1
NP_001191836.1
NP_001342440.1
NP_075529.2
XP_011239875.1
XP_017176957.1
XP_030111131.1
XP_036021858.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204906.1NP_001191835.1  ATP-dependent DNA helicase Q1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC102125, AC142413
    Consensus CDS
    CCDS57466.1
    UniProtKB/TrEMBL
    E9Q3N0
    Related
    ENSMUSP00000098394.4, ENSMUST00000100832.10
    Conserved Domains (5) summary
    TIGR00614
    Location:81543
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    cd00079
    Location:285417
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00270
    Location:93268
    DEAD; DEAD/DEAH box helicase
    pfam16124
    Location:422478
    RecQ_Zn_bind; RecQ zinc-binding
    cl09632
    Location:484576
    RQC; RQC domain
  2. NM_001204907.1NP_001191836.1  ATP-dependent DNA helicase Q1 isoform 3

    See identical proteins and their annotated locations for NP_001191836.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC102125, AK137589, AK138325
    Consensus CDS
    CCDS57465.1
    UniProtKB/Swiss-Prot
    Q9Z129
    UniProtKB/TrEMBL
    Q3UUK0
    Related
    ENSMUSP00000032370.7, ENSMUST00000032370.13
    Conserved Domains (1) summary
    TIGR00614
    Location:81543
    recQ_fam; ATP-dependent DNA helicase, RecQ family
  3. NM_001355511.1NP_001342440.1  ATP-dependent DNA helicase Q1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AC102125, AC142413
    Consensus CDS
    CCDS39695.1
    Conserved Domains (1) summary
    TIGR00614
    Location:81543
    recQ_fam; ATP-dependent DNA helicase, RecQ family
  4. NM_023042.3NP_075529.2  ATP-dependent DNA helicase Q1 isoform 1

    See identical proteins and their annotated locations for NP_075529.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AC102125, AK137589, AK164344
    Consensus CDS
    CCDS39695.1
    UniProtKB/Swiss-Prot
    Q9Z129
    Related
    ENSMUSP00000107434.3, ENSMUST00000111803.9
    Conserved Domains (1) summary
    TIGR00614
    Location:81543
    recQ_fam; ATP-dependent DNA helicase, RecQ family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    142296068..142332826 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255271.2XP_030111131.1  ATP-dependent DNA helicase Q1 isoform X3

    Conserved Domains (1) summary
    TIGR00614
    Location:81543
    recQ_fam; ATP-dependent DNA helicase, RecQ family
  2. XM_011241573.2XP_011239875.1  ATP-dependent DNA helicase Q1 isoform X2

    See identical proteins and their annotated locations for XP_011239875.1

    Conserved Domains (1) summary
    TIGR00614
    Location:81543
    recQ_fam; ATP-dependent DNA helicase, RecQ family
  3. XM_036165965.1XP_036021858.1  ATP-dependent DNA helicase Q1 isoform X2

    Conserved Domains (1) summary
    TIGR00614
    Location:81543
    recQ_fam; ATP-dependent DNA helicase, RecQ family
  4. XM_017321468.2XP_017176957.1  ATP-dependent DNA helicase Q1 isoform X1

    UniProtKB/Swiss-Prot
    Q9Z129
    Conserved Domains (1) summary
    TIGR00614
    Location:81543
    recQ_fam; ATP-dependent DNA helicase, RecQ family
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