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Rev3l REV3 like, DNA directed polymerase zeta catalytic subunit [ Mus musculus (house mouse) ]

Gene ID: 19714, updated on 25-Jan-2022

Summary

Official Symbol
Rev3lprovided by MGI
Official Full Name
REV3 like, DNA directed polymerase zeta catalytic subunitprovided by MGI
Primary source
MGI:MGI:1337131
See related
Ensembl:ENSMUSG00000019841 AllianceGenome:MGI:1337131
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rev; Rev3; Sez4
Summary
Predicted to enable DNA-directed DNA polymerase activity. Acts upstream of or within DNA repair. Located in nucleolus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and nose. Orthologous to human REV3L (REV3 like, DNA directed polymerase zeta catalytic subunit). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in CNS E18 (RPKM 11.7), whole brain E14.5 (RPKM 9.3) and 23 other tissues See more
Orthologs
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Genomic context

See Rev3l in Genome Data Viewer
Location:
10; 10 B1
Exon count:
34
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (39607557..39751207)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (39731561..39875211)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (39451966..39595012)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E130307A14 gene Neighboring gene predicted gene 8899 Neighboring gene predicted gene, 53621 Neighboring gene predicted gene, 22105 Neighboring gene 60S ribosomal protein L15 pseudogene Neighboring gene major facilitator superfamily domain containing 4B4 Neighboring gene isopentenyl-diphosphate delta isomerase, pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in error-prone translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in error-prone translesion synthesis ISO
Inferred from Sequence Orthology
more info
 
involved_in translesion synthesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of zeta DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of zeta DNA polymerase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA polymerase zeta catalytic subunit
Names
REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like
seizure-related protein 4
NP_035394.2
XP_006512685.1
XP_006512686.1
XP_006512687.1
XP_036011601.1
XP_036011602.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011264.3NP_035394.2  DNA polymerase zeta catalytic subunit

    See identical proteins and their annotated locations for NP_035394.2

    Status: VALIDATED

    Source sequence(s)
    AB031049, AC118733, AC119943
    Consensus CDS
    CCDS23790.1
    UniProtKB/Swiss-Prot
    Q61493
    Related
    ENSMUSP00000019986.7, ENSMUST00000019986.13
    Conserved Domains (5) summary
    cd05778
    Location:22862524
    DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
    cd05534
    Location:25502998
    POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
    pfam00136
    Location:25502997
    DNA_pol_B; DNA polymerase family B
    pfam14260
    Location:30343101
    zf-C4pol; C4-type zinc-finger of DNA polymerase delta
    pfam15735
    Location:7461132
    DUF4683; Domain of unknown function (DUF4683)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    39607557..39751207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512622.3XP_006512685.1  DNA polymerase zeta catalytic subunit isoform X1

    Conserved Domains (5) summary
    cd05778
    Location:22872525
    DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
    cd05534
    Location:25512999
    POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
    PTZ00166
    Location:6195
    PTZ00166; DNA polymerase delta catalytic subunit; Provisional
    pfam14260
    Location:30353102
    zf-C4pol; C4-type zinc-finger of DNA polymerase delta
    pfam15735
    Location:7471133
    DUF4683; Domain of unknown function (DUF4683)
  2. XM_006512623.5XP_006512686.1  DNA polymerase zeta catalytic subunit isoform X2

    Conserved Domains (5) summary
    cd05778
    Location:22092447
    DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
    cd05534
    Location:24732921
    POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
    PTZ00166
    Location:4117
    PTZ00166; DNA polymerase delta catalytic subunit; Provisional
    pfam14260
    Location:29573024
    zf-C4pol; C4-type zinc-finger of DNA polymerase delta
    pfam15735
    Location:6691055
    DUF4683; Domain of unknown function (DUF4683)
  3. XM_036155709.1XP_036011602.1  DNA polymerase zeta catalytic subunit isoform X4

    Conserved Domains (5) summary
    cd05778
    Location:19412179
    DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
    cd05534
    Location:22052653
    POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
    pfam14260
    Location:26892756
    zf-C4pol; C4-type zinc-finger of DNA polymerase delta
    pfam15735
    Location:407787
    DUF4683; Domain of unknown function (DUF4683)
    cd22287
    Location:15251547
    REV3L_RBD; REV7 binding domain found in protein reversionless 3-like (REV3L) and similar proteins
  4. XM_036155708.1XP_036011601.1  DNA polymerase zeta catalytic subunit isoform X4

    Conserved Domains (5) summary
    cd05778
    Location:19412179
    DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
    cd05534
    Location:22052653
    POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
    pfam14260
    Location:26892756
    zf-C4pol; C4-type zinc-finger of DNA polymerase delta
    pfam15735
    Location:407787
    DUF4683; Domain of unknown function (DUF4683)
    cd22287
    Location:15251547
    REV3L_RBD; REV7 binding domain found in protein reversionless 3-like (REV3L) and similar proteins
  5. XM_006512624.5XP_006512687.1  DNA polymerase zeta catalytic subunit isoform X3

    Conserved Domains (5) summary
    cd05778
    Location:22082446
    DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
    cd05534
    Location:24722920
    POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
    PTZ00166
    Location:4117
    PTZ00166; DNA polymerase delta catalytic subunit; Provisional
    pfam14260
    Location:29563023
    zf-C4pol; C4-type zinc-finger of DNA polymerase delta
    pfam15735
    Location:6681054
    DUF4683; Domain of unknown function (DUF4683)

RNA

  1. XR_004936129.1 RNA Sequence

    Related
    ENSMUST00000131186.8
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