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Rgs2 regulator of G-protein signaling 2 [ Mus musculus (house mouse) ]

Gene ID: 19735, updated on 23-Jun-2021

Summary

Official Symbol
Rgs2provided by MGI
Official Full Name
regulator of G-protein signaling 2provided by MGI
Primary source
MGI:MGI:1098271
See related
Ensembl:ENSMUSG00000026360
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GO; GOS8
Expression
Biased expression in bladder adult (RPKM 52.3), CNS E14 (RPKM 14.1) and 14 other tissues See more
Orthologs
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Genomic context

See Rgs2 in Genome Data Viewer
Location:
1 F; 1 62.56 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (143875076..143879887, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (143999338..144004149, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (145846468..145851279, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25663 Neighboring gene ubiquitin carboxyl-terminal esterase L5 Neighboring gene predicted gene, 41964 Neighboring gene predicted gene, 35356 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene regulator of G-protein signaling 13

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activator activity TAS
Traceable Author Statement
more info
PubMed 
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within brown fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cAMP-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cardiac muscle hypertrophy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glycine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phospholipase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in relaxation of cardiac muscle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in relaxation of vascular associated smooth muscle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
regulator of G-protein signaling 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009061.4NP_033087.2  regulator of G-protein signaling 2

    See identical proteins and their annotated locations for NP_033087.2

    Status: VALIDATED

    Source sequence(s)
    AK029310, AK031603
    Consensus CDS
    CCDS15347.1
    UniProtKB/Swiss-Prot
    O08849
    Related
    ENSMUSP00000115558.2, ENSMUST00000127206.8
    Conserved Domains (1) summary
    cd08709
    Location:84197
    RGS_RGS2; Regulator of G protein signaling (RGS) domain found in the RGS2 protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    143875076..143879887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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