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Rpl29 ribosomal protein L29 [ Mus musculus (house mouse) ]

Gene ID: 19944, updated on 5-Mar-2024

Summary

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Official Symbol
Rpl29provided by MGI
Official Full Name
ribosomal protein L29provided by MGI
Primary source
MGI:MGI:99687
See related
Ensembl:ENSMUSG00000048758 AllianceGenome:MGI:99687
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rpl43
Summary
Enables heparin binding activity. Acts upstream of or within cell population proliferation; cell-substrate adhesion; and translation. Located in cytosolic ribosome and polysomal ribosome. Is extrinsic component of membrane. Is active in synapse. Is expressed in several structures, including gonad; heart; liver; lung; and metanephros. Orthologous to human RPL29 (ribosomal protein L29). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 84.5), liver E14.5 (RPKM 83.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rpl29 in Genome Data Viewer
Location:
9 F1; 9 57.49 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (106306631..106308768)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (106428889..106431568)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:106274227-106274380 Neighboring gene STARR-positive B cell enhancer ABC_E6800 Neighboring gene dual specificity phosphatase 7 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:106296741-106296928 Neighboring gene predicted gene, 33616 Neighboring gene predicted gene, 46131 Neighboring gene STARR-seq mESC enhancer starr_25150 Neighboring gene STARR-positive B cell enhancer ABC_E11423 Neighboring gene aminoacylase 1 Neighboring gene abhydrolase domain containing 14A Neighboring gene abhydrolase domain containing 14b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Effect of HIP/ribosomal protein L29 deficiency on mineral properties of murine bones and teeth. Sloofman LG, et al. Bone, 2010 Jul. PMID 20362701, Free PMC Article
  2. Ribosomal protein L29/HIP deficiency delays osteogenesis and increases fragility of adult bone in mice. Oristian DS, et al. J Orthop Res, 2009 Jan. PMID 18661500, Free PMC Article
  3. HIP/RPL29 down-regulation accompanies terminal chondrocyte differentiation. Miller SA, et al. Differentiation, 2003 Aug. PMID 12919102
  4. Cloning, expression, and chromosome mapping of the murine Hip/Rpl29 gene. Kirn-Safran CB, et al. Genomics, 2000 Sep 1. PMID 10964519
  5. The tissue specific regulation of miR22 expression in the lung and brain by ribosomal protein L29. Ali MI, et al. Sci Rep, 2020 Oct 1. PMID 33004906, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The tissue specific regulation of miR22 expression in the lung and brain by ribosomal protein L29.
    Title: The tissue specific regulation of miR22 expression in the lung and brain by ribosomal protein L29.
  2. depletion of Rpl29 using RNA interference inhibited VEGF-induced aortic ring sprouting
    Title: Endogenous ribosomal protein L29 (RPL29): a newly identified regulator of angiogenesis in mice.
  3. Consistent with the HIP/RPL29-null bone phenotype, HIP/RPL29-deficient teeth also showed reduced geometric properties accompanied with relative increased mineral densities of both dentin and enamel.
    Title: Effect of HIP/ribosomal protein L29 deficiency on mineral properties of murine bones and teeth.
  4. L29/HIP may have a role in preventing osteogenesis and fragility of adult bone in mice
    Title: Ribosomal protein L29/HIP deficiency delays osteogenesis and increases fragility of adult bone in mice.
  5. RPL29 functions as an important regulator of global growth by modulating the rate of protein synthesis.
    Title: Global growth deficiencies in mice lacking the ribosomal protein HIP/RPL29.
  6. analyzed the expression pattern in the mammary gland especially with respect to luminal epithelial cell growth and differentiation during pregnancy and lactation
    Title: Changes in the cytologic distribution of heparin/heparan sulfate interacting protein/ribosomal protein L29 (HIP/RPL29) during in vivo and in vitro mouse mammary epithelial cell expression and differentiation.
  7. Rpl129 down-regulation accompanies terminal chondrocyte differentiation.
    Title: HIP/RPL29 down-regulation accompanies terminal chondrocyte differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107574, MGC107575, MGC107576

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heparin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell-substrate adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation at postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation at presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ribosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
large ribosomal subunit protein eL29
Names
60S ribosomal protein L29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324533.2 → NP_001311462.1  large ribosomal subunit protein eL29

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominate transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC151729
    Consensus CDS
    CCDS23476.1
    UniProtKB/Swiss-Prot
    P47915
    UniProtKB/TrEMBL
    A0A1L1SS27, D3Z1N9, Q5M8M8
    Related
    ENSMUSP00000117834.2, ENSMUST00000150576.8
    Conserved Domains (1) summary
    pfam01779
    Location:4 → 42
    Ribosomal_L29e; Ribosomal L29e protein family

  2. NM_001324534.2 → NP_001311463.1  large ribosomal subunit protein eL29

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate segment in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC151729
    Consensus CDS
    CCDS23476.1
    UniProtKB/Swiss-Prot
    P47915
    UniProtKB/TrEMBL
    A0A1L1SS27, D3Z1N9, Q5M8M8
    Related
    ENSMUSP00000149722.2, ENSMUST00000213448.2
    Conserved Domains (1) summary
    pfam01779
    Location:4 → 42
    Ribosomal_L29e; Ribosomal L29e protein family

  3. NM_009082.4 → NP_033108.1  large ribosomal subunit protein eL29

    See identical proteins and their annotated locations for NP_033108.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate segment in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC151729
    Consensus CDS
    CCDS23476.1
    UniProtKB/Swiss-Prot
    P47915
    UniProtKB/TrEMBL
    A0A1L1SS27, D3Z1N9, Q5M8M8
    Related
    ENSMUSP00000080203.6, ENSMUST00000059802.7
    Conserved Domains (1) summary
    pfam01779
    Location:4 → 42
    Ribosomal_L29e; Ribosomal L29e protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    106306631..106308768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511660.5 → XP_006511723.1  large ribosomal subunit protein eL29 isoform X1

    See identical proteins and their annotated locations for XP_006511723.1

    UniProtKB/Swiss-Prot
    P47915
    UniProtKB/TrEMBL
    A0A1L1SS27, D3Z1N9, Q5M8M8
    Conserved Domains (1) summary
    pfam01779
    Location:4 → 42
    Ribosomal_L29e; Ribosomal L29e protein family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47915.2 GenPept UniProtKB/Swiss-Prot:P47915

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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