Format

Send to:

Choose Destination

ARY Aldehyde reductase Y [ Drosophila melanogaster (fruit fly) ]

Gene ID: 19988923, updated on 5-Jan-2022

Summary

Official Symbol
ARYprovided by FlyBase
Official Full Name
Aldehyde reductase Yprovided by FlyBase
Primary source
FLYBASE:FBgn0058064
Locus tag
Dmel_CG40064
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Aldehyde reductase; CG40064; Dmel\CG40064; Y
Summary
Predicted to enable alditol:NADP+ 1-oxidoreductase activity and indanol dehydrogenase activity. Predicted to be active in cytosol. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to several human genes including AKR1B10 (aldo-keto reductase family 1 member B10) and AKR1B15 (aldo-keto reductase family 1 member B15). [provided by Alliance of Genome Resources, Nov 2021]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ARY in Genome Data Viewer
Location:
chromosome: Y
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) Y NC_024512.1 (702430..704048)

Chromosome Y - NC_024512.1Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene male fertility factor kl3 Neighboring gene male fertility factor kl2 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

Genomic Sequence:
NC_024512.1 Chromosome Y Reference Release 6 plus ISO1 MT Primary Assembly

General gene information

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables D-threo-aldose 1-dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables alditol:NADP+ 1-oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables indanol dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
aldehyde reductase Y
Names
ARY-PC
ARY-PD
CG40064-PC
CG40064-PD
NP_001015363.3
NP_001163844.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_024512.1 Reference assembly

    Range
    702430..704048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170373.2NP_001163844.1  aldehyde reductase Y, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163844.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D2A6K3
    Related
    FBpp0291022, FBtr0301808
    Conserved Domains (2) summary
    COG0656
    Location:37332
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:50324
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
  2. NM_001015363.4NP_001015363.3  aldehyde reductase Y, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001015363.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7PLK6
    Related
    FBpp0291021, FBtr0301807
    Conserved Domains (2) summary
    COG0656
    Location:42314
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:45306
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
Support Center