Pdc phosducin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pdcprovided by MGI
Official Full Name: phosducinprovided by MGI
Primary source: MGI:MGI:98090
See related: Ensembl:ENSMUSG00000006007 AllianceGenome:MGI:98090
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rpr1; Rpr-1
Summary: Predicted to be involved in regulation of G protein-coupled receptor signaling pathway. Predicted to act upstream of or within visual perception. Located in photoreceptor outer segment. Is expressed in central nervous system; foot; skeleton; and spinal nerve plexus. Orthologous to human PDC (phosducin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 1 G1; 1 63.84 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (150195168..150209657)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (150319417..150333906)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the role of phosducin at the rod-to-rod bipolar cell (RBC) synapse
Title: Absence of synaptic regulation by phosducin in retinal slices.
A major regulatory component responsible for setting the sensitivity of signal transmission between photoreceptors and ON-bipolar cells is confined to photoreceptors and that phosducin participates in the underlying molecular mechanism.
Title: Phosducin regulates transmission at the photoreceptor-to-ON-bipolar cell synapse.
Pdc-/- mice displayed exaggerated increases in blood pressure in response to post-operative stress.
Title: Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice.
Dopamine and other light-dependent processes cooperatively regulate the diurnal rhythm of phosducin phosphorylation. Dopamine release in response to light and circadian clocks drives daily rhythms of protein phosphorylation in photoreceptor cells.
Title: Dopamine modulates diurnal and circadian rhythms of protein phosphorylation in photoreceptor cells of mouse retina.
Phosducin does not contribute to adaptation mechanisms of the outer segment by dynamically controlling heterotrimer availability, but is necessary for maintaining normal transducin expression and therefore normal flash sensitivity in rods.
Title: Phosducin regulates the expression of transducin betagamma subunits in rod photoreceptors and does not contribute to phototransduction adaptation.
phosducin has a role in regulating signaling in the rod outer segment compartment and there are distinct functions for phosphorylation sites 54 and 71
Title: Compartment-specific phosphorylation of phosducin in rods underlies adaptation to various levels of illumination.
data suggest that phosducin action is based on the reduction of transducin affinity to the membranes of rod outer segments, achieved by keeping the transducin beta gamma subunits apart from the alpha subunit
Title: Phosducin facilitates light-driven transducin translocation in rod photoreceptors. Evidence from the phosducin knockout mouse.
The increased retinal degeneration 1 phosducin phosphorylation coincided with increased activation of calcium/calmodulin-activated protein kinase II, which is known to utilize phosducin as a substrate.
Title: Differential modification of phosducin protein in degenerating rd1 retina is associated with constitutively active Ca2+/calmodulin kinase II in rod outer segments.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Mit200 (e-PCR), detects polymorphism
- UniSTS:128541

Pdc (e-PCR), detects polymorphism
- UniSTS:463217

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in photoreceptor outer segment	IBA Inferred from Biological aspect of Ancestor more info
located_in photoreceptor outer segment	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phosducin

Names: 33 kDa phototransducing protein; PHD; rod photoreceptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159730.1 → NP_001153202.1 phosducin

See identical proteins and their annotated locations for NP_001153202.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.

Source sequence(s)

AK020798, BC012507, BE950243, BI738229

Consensus CDS

CCDS15354.1

UniProtKB/Swiss-Prot

Q9QW08

Related

ENSMUSP00000131631.2, ENSMUST00000165062.8

Conserved Domains (2) summary

cd02987
Location:14 → 223

Phd_like_Phd; Phosducin (Phd)-like family, Phd subfamily; Phd is a cytosolic regulator of G protein functions. It specifically binds G protein betagamma (Gbg)-subunits with high affinity, resulting in the solubilization of Gbg from the plasma membrane. This impedes ...

pfam02114
Location:1 → 244

Phosducin; Phosducin
NM_024458.2 → NP_077778.1 phosducin

See identical proteins and their annotated locations for NP_077778.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.

Source sequence(s)

AK020798, BC012507, BE950243

Consensus CDS

CCDS15354.1

UniProtKB/Swiss-Prot

Q9QW08

Related

ENSMUSP00000141136.2, ENSMUST00000191228.7

Conserved Domains (2) summary

cd02987
Location:14 → 223

Phd_like_Phd; Phosducin (Phd)-like family, Phd subfamily; Phd is a cytosolic regulator of G protein functions. It specifically binds G protein betagamma (Gbg)-subunits with high affinity, resulting in the solubilization of Gbg from the plasma membrane. This impedes ...

pfam02114
Location:1 → 244

Phosducin; Phosducin