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S100b S100 protein, beta polypeptide, neural [ Mus musculus (house mouse) ]

Gene ID: 20203, updated on 27-Jul-2021

Summary

Official Symbol
S100bprovided by MGI
Official Full Name
S100 protein, beta polypeptide, neuralprovided by MGI
Primary source
MGI:MGI:98217
See related
Ensembl:ENSMUSG00000033208
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bpb; AI850290
Expression
Biased expression in cerebellum adult (RPKM 164.7), frontal lobe adult (RPKM 54.2) and 1 other tissue See more
Orthologs
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Genomic context

See S100b in Genome Data Viewer
Location:
10 C1; 10 38.76 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (76089670..76097153)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (76253836..76261319)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (75716581..75724064)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L32 pseudogene Neighboring gene microRNA 678 Neighboring gene protein arginine N-methyltransferase 2 Neighboring gene disco interacting protein 2 homolog A Neighboring gene predicted gene, 40699 Neighboring gene pericentrin (kendrin) Neighboring gene RIKEN cDNA 1700094J05 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC74317

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RAGE receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RAGE receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables S100 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables S100 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
enables calcium-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular calcium ion homeostasis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in energy reserve metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in learning or memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of skeletal muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of myelination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytokine production NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of long-term neuronal synaptic plasticity NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein S100-B
Names
S-100 protein beta chain
S-100 protein subunit beta
S100 calcium-binding protein B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009115.3NP_033141.1  protein S100-B

    See identical proteins and their annotated locations for NP_033141.1

    Status: VALIDATED

    Source sequence(s)
    AK135083, AW456919, BC061178, CX205737
    Consensus CDS
    CCDS35943.1
    UniProtKB/Swiss-Prot
    P50114
    UniProtKB/TrEMBL
    Q3UY00
    Related
    ENSMUSP00000047968.8, ENSMUST00000036387.8
    Conserved Domains (2) summary
    cd05027
    Location:289
    S-100B; S-100B: S-100B domain found in proteins similar to S100B. S100B is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...
    pfam13499
    Location:2778
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    76089670..76097153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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