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Scd1 stearoyl-Coenzyme A desaturase 1 [ Mus musculus (house mouse) ]

Gene ID: 20249, updated on 12-Sep-2021

Summary

Official Symbol
Scd1provided by MGI
Official Full Name
stearoyl-Coenzyme A desaturase 1provided by MGI
Primary source
MGI:MGI:98239
See related
Ensembl:ENSMUSG00000037071
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SC; ab; Scd; Scd-; Scd-1; AA589638; AI265570
Expression
Biased expression in subcutaneous fat pad adult (RPKM 3754.4), mammary gland adult (RPKM 3202.4) and 5 other tissues See more
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Genomic context

See Scd1 in Genome Data Viewer
Location:
19 C3; 19 37.98 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (44382889..44396148, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (44394450..44407709, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (44468940..44482199, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene stearoyl-Coenzyme A desaturase 2 Neighboring gene microRNA 5114 Neighboring gene stearoyl-coenzyme A desaturase 4 Neighboring gene predicted gene, 35406 Neighboring gene wingless-type MMTV integration site family, member 8B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within brown fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cholesterol esterification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within lipid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in monounsaturated fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within monounsaturated fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within monounsaturated fatty acid biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in monounsaturated fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cholesterol esterification TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of water loss via skin IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to fatty acid ISO
Inferred from Sequence Orthology
more info
 
involved_in sebaceous gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sterol esterification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tarsal gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in triglyceride metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in unsaturated fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in unsaturated fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within white fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in integral component of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
acyl-CoA desaturase 1
Names
asebia
delta(9)-desaturase 1
fatty acid desaturase 1
stearoyl-CoA desaturase 1
NP_033153.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009127.4NP_033153.2  acyl-CoA desaturase 1

    See identical proteins and their annotated locations for NP_033153.2

    Status: VALIDATED

    Source sequence(s)
    AA881780, AK012370, AK148103, BQ885468, BU053011, CD544724
    Consensus CDS
    CCDS29850.1
    UniProtKB/Swiss-Prot
    P13516
    UniProtKB/TrEMBL
    Q547C4
    Related
    ENSMUSP00000036936.3, ENSMUST00000041331.4
    Conserved Domains (2) summary
    cd03505
    Location:93333
    Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...
    pfam00487
    Location:98301
    FA_desaturase; Fatty acid desaturase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    44382889..44396148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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