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Scn7a sodium channel, voltage-gated, type VII, alpha [ Mus musculus (house mouse) ]

Gene ID: 20272, updated on 6-May-2021

Summary

Official Symbol
Scn7aprovided by MGI
Official Full Name
sodium channel, voltage-gated, type VII, alphaprovided by MGI
Primary source
MGI:MGI:102965
See related
Ensembl:ENSMUSG00000034810
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
N; Sc; NaG; Nav; Nax; Nav2; Scn6a; Nav2.3; AI642000; 1110034K09Rik
Expression
Biased expression in lung adult (RPKM 20.0), bladder adult (RPKM 6.6) and 4 other tissues See more
Orthologs
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Genomic context

See Scn7a in Genome Data Viewer
Location:
2 C1.3; 2 39.21 cM
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (66503770..66615254, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (66673426..66784910, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (66511483..66622967, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ribosomal protein L35, pseudogene 1 Neighboring gene predicted gene 13629 Neighboring gene sodium channel, voltage-gated, type IX, alpha Neighboring gene predicted gene, 35265 Neighboring gene predicted gene 13600 Neighboring gene eukaryotic translation initiation factor 2 subunit 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sodium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables voltage-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in membrane depolarization during action potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuronal action potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within sodium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within sodium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in glial cell projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of voltage-gated sodium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
sodium channel protein type 7 subunit alpha
Names
sodium channel, voltage-gated, type VI, alpha polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009135.2NP_033161.2  sodium channel protein type 7 subunit alpha

    Status: VALIDATED

    Source sequence(s)
    AL928623, AL928720
    Consensus CDS
    CCDS16081.1
    UniProtKB/TrEMBL
    B1AYL1, Q62467
    Related
    ENSMUSP00000042405.7, ENSMUST00000042792.7
    Conserved Domains (3) summary
    cd13433
    Location:11951246
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:9511204
    Ion_trans; Ion transport protein
    pfam06512
    Location:743927
    Na_trans_assoc; Sodium ion transport-associated

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    66503770..66615254 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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